2-(二甲氨基)-1-(6-苯基甲氧基萘-2-基)丙烷-1-酮 | 834914-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-(二甲氨基)-1-(6-苯基甲氧基萘-2-基)丙烷-1-酮
• 英文名称: 1-(6-Benzyloxy-naphthalen-2-yl)-2-dimethylamino-propan-1-one
• 英文别名: 1-[6-(Benzyloxy)naphthalen-2-yl]-2-(dimethylamino)propan-1-one；2-(dimethylamino)-1-(6-phenylmethoxynaphthalen-2-yl)propan-1-one
• CAS: 834914-41-9
• 化学式: C₂₂H₂₃NO₂
• 分子量: 333.43
• InChiKey: ZMOURWQUBJFHIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(二甲氨基)-1-(6-苯基甲氧基萘-2-基)丙烷-1-酮 在 sodium tetrahydroborate 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 [2-(6-Benzyloxy-naphthalen-2-yl)-2-imidazol-1-yl-1-methyl-ethyl]-dimethyl-amine
  参考文献：
  名称：

  Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)

  摘要：

  A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's). © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.044
• 作为产物：
  描述：

  2-(二甲氨基)-1-(6-甲氧基萘-2-基)丙烷-1-酮 在 偶氮二甲酸二异丙酯 、 氢溴酸 、 溶剂黄146 、 三苯基膦 作用下， 生成 2-(二甲氨基)-1-(6-苯基甲氧基萘-2-基)丙烷-1-酮
  参考文献：
  名称：

  Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)

  摘要：

  A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's). © 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.044

文献信息

• [EN] NAPHTHYLENE DERIVATIVES AS CYTOCHROME P450 INHIBITORS<br/>[FR] DERIVES DE NAPHTYLENE CONSTITUANT DES INHIBITEURS DU CYTOCHROME P450
  申请人：OSI PHARM INC

  公开号：WO2005007631A1

  公开（公告）日：2005-01-27

  Compounds of the formula (I); and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G 1,Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.

  该式（I）的化合物及其药用盐，其中n1、n2、n3、n4、G 1、Q1、Z、R1、R2、R3、R4a、R4b、R5a和R5b在此处被定义，抑制细胞色素P450RAI酶，适用于治疗和/或预防对维甲酸类药物和天然存在的视黄酸有反应的各种疾病和病况。
• Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)
  作者：Mark J. Mulvihill、Julie L.C. Kan、Patricia Beck、Mark Bittner、Cara Cesario、Andrew Cooke、David M. Keane、Anthony I. Nigro、Christy Nillson、Vanessa Smith、Mary Srebernak、Feng-Lei Sun、Michael Vrkljan、Shannon L. Winski、Arlindo L. Castelhano、David Emerson、Neil Gibson

  DOI：10.1016/j.bmcl.2005.01.044

  日期：2005.3

  A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's). © 2005 Elsevier Ltd. All rights reserved.