UDP-N-Acetylmuramyl-L-alanine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: UDP-N-Acetylmuramyl-L-alanine
• 化学式: C₂₃H₃₆N₄O₂₀P₂
• 分子量: 750.501
• InChiKey: NTMMCWJNQNKACG-NVKQZXRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.65
• 重原子数：
  49.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  361.26
• 氢给体数：
  10.0
• 氢受体数：
  18.0

反应信息

• 作为产物：
  描述：

  uridine-5’-diphospho-N-acetyl-glucosamine 在 DL-dithiothreitol 、 三羟甲基甲胺基丙磺酸 、 5’-三磷酸腺苷 、 还原型辅酶II(NADPH)四钠盐 、 magnesium chloride 作用下， 以 水 为溶剂， 反应 10.0h， 生成 UDP-N-Acetylmuramyl-L-alanine
  参考文献：
  名称：

  Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

  摘要：

  The first six cytoplasmic intermediates of murein biosynthesis (2-7) have been prepared in high yield (>60%) and at preparative scale (10-100 mg) using purified enzymes of the murein biosynthetic pathway (MurA-MurF). For at least three of these compounds, 5, 6, and 7, this is the first high-yield synthesis and purification by any means that has been reported. Detailed spectroscopic and analytical data accompany each of the six compounds and serve as reference standards for future work. The availability of these intermediates will facilitate the study of the murein pathway enzymes MurA-MurF, all of which are validated antibacterial targets.

  DOI：

  10.1021/ja983850b

文献信息

• Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis
  作者：Sreelatha G. Reddy、Sherman T. Waddell、David W. Kuo、Kenny K. Wong、David L. Pompliano

  DOI：10.1021/ja983850b

  日期：1999.2.1

  The first six cytoplasmic intermediates of murein biosynthesis (2-7) have been prepared in high yield (>60%) and at preparative scale (10-100 mg) using purified enzymes of the murein biosynthetic pathway (MurA-MurF). For at least three of these compounds, 5, 6, and 7, this is the first high-yield synthesis and purification by any means that has been reported. Detailed spectroscopic and analytical data accompany each of the six compounds and serve as reference standards for future work. The availability of these intermediates will facilitate the study of the murein pathway enzymes MurA-MurF, all of which are validated antibacterial targets.