dimethyl 2-ethyl-2-phenylmalonate | 88253-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 2-ethyl-2-phenylmalonate
• 英文别名: ethyl-phenyl-malonic acid dimethyl ester；Aethyl-phenyl-malonsaeure-dimethylester；Aethyl-phenyl-malonsaeuredimethylester；Propanedioic acid, ethylphenyl-, dimethyl ester；dimethyl 2-ethyl-2-phenylpropanedioate
• CAS: 88253-95-6
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: NKCLMVJSYCXQLT-UHFFFAOYSA-N

物化性质

• 熔点：
  39.5 °C
• 沸点：
  151-153 °C(Press: 7 Torr)
• 密度：
  1.111±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dimethyl 2-ethyl-2-phenylmalonate 在 甲醇 、 sodium hydroxide 、 sodium tetrahydroborate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.25h， 生成 2-苯基丁酸甲酯
  参考文献：
  名称：

  Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (−)- and (+)-aminoglutethimides AG and analogues

  摘要：

  From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00122-x
• 作为产物：
  描述：

  苯丙二酸 在 正丁基锂 、 氯化亚砜 、 magnesium sulfate 作用下， 反应 10.0h， 生成 dimethyl 2-ethyl-2-phenylmalonate
  参考文献：
  名称：

  Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (−)- and (+)-aminoglutethimides AG and analogues

  摘要：

  From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00122-x

文献信息

• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2876118A1

  公开（公告）日：2015-05-27

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds selected from specific aromatic dicarboxylic diesters into contact with each other to effect a reaction, followed by washing, a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing, and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种选自特定芳香族二羧酸二酯的第一内部电子供体化合物相互接触以发生反应，然后进行洗涤、第二步：使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；第三步：使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP2963063A1

  公开（公告）日：2016-01-06

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds excluding an aromatic dicarboxylic acid diester into contact with each other to effect a reaction, followed by washing; a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing; and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种第一内部电子供体化合物（不包括芳香族二羧酸二酯）相互接触以发生反应，然后进行洗涤；第二步，使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；以及第三步，使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• N-BENZYLAMIDES AS DERIVATIVES FOR IDENTIFYING THE ACYL GROUP IN ESTERS^1,2
  作者：O. C. DERMER、JACK KING

  DOI：10.1021/jo01190a008

  日期：1943.3
• Rising; Stieglitz, Journal of the American Chemical Society, 1918, vol. 40, p. 728
  作者：Rising、Stieglitz

  DOI：——

  日期：——
• Rising; Zee, Journal of the American Chemical Society, 1928, vol. 50, p. 1210
  作者：Rising、Zee

  DOI：——

  日期：——