氯氧代乙酸 4-硝基苯基酯 | 78974-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 氯氧代乙酸 4-硝基苯基酯
• 中文别名: 氯氧代乙酸4-硝基苯基酯
• 英文名称: p-nitrobenzyl chlorooxalate
• 英文别名: p-nitrophenyl oxalyl chloride；p-Nitrophenyl chloroglyoxylate；Chlorooxoacetic acid 4-nitrophenyl ester；(4-nitrophenyl) 2-chloro-2-oxoacetate
• CAS: 78974-67-1
• 化学式: C₈H₄ClNO₅
• 分子量: 229.576
• InChiKey: ANLIRQCCCSNMMO-UHFFFAOYSA-N

物化性质

• 沸点：
  335.3±34.0 °C(Predicted)
• 密度：
  1.557±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯氧代乙酸 4-硝基苯基酯 、 2',3'-双脱氧腺苷 在 吡啶 、 4-二甲氨基吡啶 作用下， 生成 Oxalic acid (2S,5R)-5-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester
  参考文献：
  名称：

  Synthesis of the 2',3'-dideoxynucleoside derivatives of the specific binding peptide part of CD4.

  摘要：

  特定结合肽部分CD4与HIV包膜蛋白gp120的2'，3'-双脱氧核苷类似物已被合成。

  DOI：

  10.1248/cpb.39.3091
• 作为产物：
  描述：

  对硝基苯酚 、 草酰氯 反应 16.0h， 生成 氯氧代乙酸 4-硝基苯基酯
  参考文献：
  名称：

  Synthesis of the 2',3'-dideoxynucleoside derivatives of the specific binding peptide part of CD4.

  摘要：

  特定结合肽部分CD4与HIV包膜蛋白gp120的2'，3'-双脱氧核苷类似物已被合成。

  DOI：

  10.1248/cpb.39.3091

文献信息

• Photoactivated Coumaryl-diazopyruvate Fluorescent Label for Amine Functional Groups of Tissues Containing Type-I Collagen¶
  作者：George T. Timberlake、G. Kesava Reddy、Lisa Stehno-Bittel、Jörg F. Weber、Sabine Amslinger、Richard S. Givens

  DOI：10.1562/0031-8655(2002)076<0473:pcdflf>2.0.co;2

  日期：——

  The design, synthesis and application of a new fluorescent-labeling reagent for collagen has been developed as a prerequisite for the design of a photoactivated collagen-crosslinking compound for surgical wound closure. The amine groups in collagen are the targets of a rational design for a new fluorophore because natural collagen crosslinks are formed between primary (1) amine groups of lysine and hydroxylysine. The availability of 1degrees amines for crosslinking in native collagenous tissues was evaluated by reacting tendon and corneal samples with o-phthalaldehyde and dansyl chloride, fluorophores commonly used for the detection of 1 and 2 amines. The resulting fluorescent collagen fibrils indicated the presence of amines in native tissue. Subsequently, a photoactivated fluorescent label for 1 and 2 amines, coumaryl gamma-amino-butyric acid diazopyruvate (CGDP), was designed and synthesized. CGDP was first used to photolabel poly-L-lysine, forming a fluorescent, covalent bond to the 1 amine. CGDP was then photoreacted with corneal and tendon tissue samples to produce CGDP fluorescent-labeled samples that were statistically significantly more fluorescent than were the controls. These experiments support the postulate that 1 or 2 (or both) amines in native collagenous tissues are available to serve as targets for photoactivated collagen crosslinkers for wound closure.
• The Synthesis of 1b-Fluorocarbapenem Derivative
  作者：Keiichiro Fukumoto、Masataka Ihara、Ken Satoh、Yohhei Ishida、Nobuaki Taniguchi、Yuji Tokunaga、Makoto Takemura

  DOI：10.3987/com-95-s69

  日期：——
• HAMANAKA, ERNEST S.
  作者：HAMANAKA, ERNEST S.

  DOI：——

  日期：——
• JPH00586096A
  申请人：——

  公开号：JPH00586096A

  公开（公告）日：1993-04-06
• JPH0586096A
  申请人：——

  公开号：JPH0586096A

  公开（公告）日：1993-04-06