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2-氨基-5-碘三氟甲基苯 | 97760-97-9

中文名称
2-氨基-5-碘三氟甲基苯
中文别名
2-氨基-5-碘三氟甲苯;4-碘-2-三氟甲基苯胺
英文名称
4-iodo-2-(trifluoromethyl)aniline
英文别名
2-Amino-5-iodobenzotrifluoride
2-氨基-5-碘三氟甲基苯化学式
CAS
97760-97-9
化学式
C7H5F3IN
mdl
MFCD04972657
分子量
287.023
InChiKey
MAJKZNONEQIIGP-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    262℃
  • 密度:
    1.948
  • 闪点:
    112℃

计算性质

  • 辛醇/水分配系数(LogP):
    2.8
  • 重原子数:
    12
  • 可旋转键数:
    0
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.142
  • 拓扑面积:
    26
  • 氢给体数:
    1
  • 氢受体数:
    4

安全信息

  • 危险等级:
    IRRITANT
  • 危险品标志:
    Xi
  • 安全说明:
    S26,S36/37/39
  • 危险类别码:
    R20/21/22
  • 海关编码:
    2921420090
  • 危险性防范说明:
    P261,P305+P351+P338
  • 危险性描述:
    H315,H319,H335
  • 储存条件:
    存储条件为2-8°C,避光,并在惰性气体环境中保存。

SDS

SDS:b9ec85793be3dea33bf59454e5829692
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Material Safety Data Sheet

Section 1. Identification of the substance
Product Name: 4-Iodo-2-trifluoromethylaniline
Synonyms:

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: 4-Iodo-2-trifluoromethylaniline
CAS number: 97760-97-9

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H5F3IN
Molecular weight: 287.0

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride, hydrogen Iodide.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    2-氨基-5-碘三氟甲基苯sodium hydroxide 作用下, 以 六甲基磷酰三胺乙醇甲苯 为溶剂, 反应 13.0h, 生成 4-氨基-3-三氟甲基苯甲酸
    参考文献:
    名称:
    Kruger; Keck; Noll, Arzneimittel-Forschung/Drug Research, 1984, vol. 34, # 11 A, p. 1612 - 1624
    摘要:
    DOI:
  • 作为产物:
    描述:
    邻氨基三氟甲苯一氯化碘 作用下, 以 二氯甲烷 为溶剂, 反应 12.0h, 以42.48%的产率得到2-氨基-5-碘三氟甲基苯
    参考文献:
    名称:
    Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
    摘要:
    本发明涉及化合物的结构式(I),其中R3代表C2-C5烯基或C2-C5炔基,其他变量如权利要求书中所定义,其异构体或其药学上可接受的盐作为辣椒素受体(辣椒素受体1; VR1; TRPV1)拮抗剂;以及含有该化合物的药物组合物。本发明提供了一种用于预防或治疗疼痛、关节炎炎症性疾病、尿道膀胱过敏(包括尿失禁)、胃十二指肠溃疡、肠易激综合征、炎症性肠病、神经性/过敏/炎症性皮肤病、银屑病、哮喘、慢性阻塞性肺病、瘙痒或痒疹的药物组合物。
    公开号:
    EP1862454A1
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文献信息

  • 三氟甲基化苯胺类化合物的制备方法
    申请人:浙江工业大学
    公开号:CN112062681A
    公开(公告)日:2020-12-11
    一种式(IIA)或式(IIB)所示的三甲基化苯胺类化合物的制备方法,所述的方法包括以下步骤:以体积比为1:1~4的DMF混合溶剂为反应介质,加入式(IA)或式(IB)所示的苯胺类化合物、1‑(三甲基)‑1,2‑苯酰‑3(1H)‑酮和光催化剂,在蓝光下室温反应2~6h,反应完全后,所得反应混合物经后处理得到式(IIA)或式(IIB)所示的三甲基化苯胺类化合物。本发明利用光催化剂,在可见光照射下驱动反应进行,反应条件温和、位点选择性高,反应高效,绿色,环保,反应收率可达到90%,仅需一步即可制得产物。
  • Visible-light-mediated direct perfluoroalkylation and trifluoromethylation of free anilines
    作者:Chun-Yang He、Ji-Wei Gu、Xingang Zhang
    DOI:10.1016/j.tetlet.2017.09.010
    日期:2017.10
    A mild, operationally simple method for direct perfluoroalkylation and trifluoromethylation of anilines through visible-light-mediated photoredox catalysis from broadly available perfluoroalkyl iodides and free anilines is described. The method provides a facile route for application in drug discovery and development.
    描述了一种温和的,操作简单的方法,该方法通过可见光介导的光氧化还原催化从广泛可得的全氟烷基和游离苯胺直接进行苯胺全氟烷基化和三甲基化。该方法提供了在药物发现和开发中应用的简便途径。
  • Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
    申请人:Dow AgroSciences LLC
    公开号:US20170064962A1
    公开(公告)日:2017-03-09
    This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫有用的杀虫性的分子领域,用于生产这种分子的过程,用于这种过程的中间体,含有这种分子的杀虫组合物,以及使用这种杀虫组合物对这些害虫进行处理的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式(“式一”)的分子。
  • Transition metal-free direct C H trifluoromethyltion of (hetero)arenes with Togni’s reagent
    作者:Xiaoyu Chen、Licheng Ding、Linlin Li、Jingya Li、Dapeng Zou、Yangjie Wu、Yusheng Wu
    DOI:10.1016/j.tetlet.2019.151538
    日期:2020.2
    A new transition-metal-free direct C−H trifluoromethylation reaction of (hetero)arenes with Togni’s reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.
    开发了一种新的无杂芳烃与Togni's试剂的无过渡属直接C-H三甲基化反应。该转化在温和条件下平稳进行,并且表现出对许多合成相关官能团的良好耐受性。它为合成三甲基化(杂)芳烃提供了另一种方法。
  • Nickel-Catalyzed Direct C–H Trifluoromethylation of Free Anilines with Togni’s Reagent
    作者:Xianying Gao、Yang Geng、Shuaijun Han、Apeng Liang、Jingya Li、Dapeng Zou、Yusheng Wu、Yangjie Wu
    DOI:10.1021/acs.orglett.8b01216
    日期:2018.7.6
    nickel-catalyzed C–H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni’s reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.
    已经开发出一种有效的催化的C–H三甲基化,用于使用Togni试剂合成三甲基化的游离苯胺。该方法在温和条件下显示出良好的官能团耐受性,良好的区域选择性和化学选择性。新开发的经济型一步法是合成三甲基化游离苯胺的更好选择。
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