4-氯-3,5-二硝基苯基甲基砜 | 4726-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氯-3,5-二硝基苯基甲基砜
• 英文名称: 2,6-Dinitro-4-(methyl-sulfonyl)-chlorbenzol
• 英文别名: 4-Chloro-3,5-dinitrophenylmethyl sulfone；2-chloro-5-methylsulfonyl-1,3-dinitrobenzene
• CAS: 4726-15-2
• 化学式: C₇H₅ClN₂O₆S
• 分子量: 280.645
• InChiKey: XOXDOVDWSOCMQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  134
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-氯-3,5-二硝基苯基甲基砜 在 盐酸 、 sodium hydroxide 、 铁粉 、 三乙胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-[2-Chloro-5-methanesulfonyl-3-(oxalyl-amino)-phenyl]-oxalamic acid
  参考文献：
  名称：

  N,N'-(phenylene)dioxamic acids and their esters as antiallergy agents

  摘要：

  A series of dialkyl N,N'-(m-phenylene)dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine. Hydrolysis with sodium hydroxide solution gave the corresponding N,N'-(m-phenylene)dioxamic acids. Several N,N'-(p-phenylene)dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. These compounds were tested in the rat passive cutaneous anaphylaxis (PCA) assay. When tested iv, activity was found in the N,N'-(m-phenylene) dioxamic acids up to 2500 times that shown by disodium cromoglycate [50% inhibition at 0.001 mg/kg for N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid (compound 61)]. Oral activity was seen in this series of compounds with duration of activity up to 120 min. Oral activity was detected in diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate (compound 38) at levels of drug as low as 0.1 mg/kg.

  DOI：

  10.1021/jm00207a016
• 作为产物：
  描述：

  2,6-二硝基-4-甲基磺酰苯酚 在 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-氯-3,5-二硝基苯基甲基砜
  参考文献：
  名称：

  N,N'-(phenylene)dioxamic acids and their esters as antiallergy agents

  摘要：

  A series of dialkyl N,N'-(m-phenylene)dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine. Hydrolysis with sodium hydroxide solution gave the corresponding N,N'-(m-phenylene)dioxamic acids. Several N,N'-(p-phenylene)dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. These compounds were tested in the rat passive cutaneous anaphylaxis (PCA) assay. When tested iv, activity was found in the N,N'-(m-phenylene) dioxamic acids up to 2500 times that shown by disodium cromoglycate [50% inhibition at 0.001 mg/kg for N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid (compound 61)]. Oral activity was seen in this series of compounds with duration of activity up to 120 min. Oral activity was detected in diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate (compound 38) at levels of drug as low as 0.1 mg/kg.

  DOI：

  10.1021/jm00207a016

文献信息

• GB1128217
  申请人：——

  公开号：——

  公开（公告）日：——
• ECKSTEIN Z.; EJMOCKI Z.; KAMINSKI J., PRZ. CHEM., 1979, 58, NO 7, 359-362
  作者：ECKSTEIN Z.、 EJMOCKI Z.、 KAMINSKI J.

  DOI：——

  日期：——
• STACH, L. J.;CHEN, SUN, M.
  作者：STACH, L. J.、CHEN, SUN, M.

  DOI：——

  日期：——
• CLARK, N. G.;GARRETT, K. J., J. CHEM. RES. SYNOP., 1984, N 10, 336-337
  作者：CLARK, N. G.、GARRETT, K. J.

  DOI：——

  日期：——
• N,N'-(phenylene)dioxamic acids and their esters as antiallergy agents
  作者：John B. Wright、Charles M. Hall、Herbert G. Johnson

  DOI：10.1021/jm00207a016

  日期：1978.9

  A series of dialkyl N,N'-(m-phenylene)dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine. Hydrolysis with sodium hydroxide solution gave the corresponding N,N'-(m-phenylene)dioxamic acids. Several N,N'-(p-phenylene)dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. These compounds were tested in the rat passive cutaneous anaphylaxis (PCA) assay. When tested iv, activity was found in the N,N'-(m-phenylene) dioxamic acids up to 2500 times that shown by disodium cromoglycate [50% inhibition at 0.001 mg/kg for N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid (compound 61)]. Oral activity was seen in this series of compounds with duration of activity up to 120 min. Oral activity was detected in diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate (compound 38) at levels of drug as low as 0.1 mg/kg.