5-carbamoyl-2,3'-bipyridine | 164074-61-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-carbamoyl-2,3'-bipyridine
• 英文别名: [2,3'-Bipyridine]-5-carboxamide；6-pyridin-3-ylpyridine-3-carboxamide
• CAS: 164074-61-7
• 化学式: C₁₁H₉N₃O
• 分子量: 199.212
• InChiKey: SWRNFHIFFNQMTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-carbamoyl-2,3'-bipyridine 、 碘甲烷 以 乙酸乙酯 为溶剂， 以80%的产率得到5-carbamoyl-1'-methyl-2,3'-bipyridinium iodide
  参考文献：
  名称：

  N-methylation and N-oxidation of the less reactive nitrogen atom of a 2,3′-bipyridine. Two general methods for polyazines

  摘要：

  5-Carbamoyl-2,3'-bipyridine model compound was N-methylated or N-oxidized at the less reactive 2-pyridyl ring for the first time. Two different schemes were developed.

  DOI：

  10.1016/0040-4020(95)00074-i
• 作为产物：
  描述：

  6-氯烟酰胺 、 二乙基(3-吡啶基)-硼烷 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.0h， 以92%的产率得到5-carbamoyl-2,3'-bipyridine
  参考文献：
  名称：

  N-methylation and N-oxidation of the less reactive nitrogen atom of a 2,3′-bipyridine. Two general methods for polyazines

  摘要：

  5-Carbamoyl-2,3'-bipyridine model compound was N-methylated or N-oxidized at the less reactive 2-pyridyl ring for the first time. Two different schemes were developed.

  DOI：

  10.1016/0040-4020(95)00074-i

文献信息

• ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS
  申请人：Ravenna Pharmaceuticals, Inc.

  公开号：EP3728230A1

  公开（公告）日：2020-10-28
• N-methylation and N-oxidation of the less reactive nitrogen atom of a 2,3′-bipyridine. Two general methods for polyazines
  作者：John A. Zoltewicz、Michael P. Cruskie

  DOI：10.1016/0040-4020(95)00074-i

  日期：1995.3

  5-Carbamoyl-2,3'-bipyridine model compound was N-methylated or N-oxidized at the less reactive 2-pyridyl ring for the first time. Two different schemes were developed.