碳酸2,5-二氧代-1-吡咯烷基2-(乙烯基磺酰基)乙酯 | 918822-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 碳酸2,5-二氧代-1-吡咯烷基2-(乙烯基磺酰基)乙酯
• 中文别名: 碳酸2,5-二氧代-1-吡咯烷基2-（乙烯基磺酰基）乙基酯
• 英文名称: succinimidyl 2-vinylsulfonylethyl carbonate
• 英文别名: 2,5-dioxopyrrolidin-1-yl (2-(vinylsulfonyl)ethyl)carbonate；Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 2-(Ethenylsulfonyl)ethyl Ester；(2,5-dioxopyrrolidin-1-yl) 2-ethenylsulfonylethyl carbonate
• CAS: 918822-70-5
• 化学式: C₉H₁₁NO₇S
• 分子量: 277.255
• InChiKey: SJPUQNFPDYCHBX-UHFFFAOYSA-N

物化性质

• 熔点：
  95 - 102°C
• 溶解度：
  可溶于氯仿（略微加热）、甲醇（略微加热）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  碳酸2,5-二氧代-1-吡咯烷基2-(乙烯基磺酰基)乙酯 在 碳酸氢钠 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 1.25h， 生成 (S)-2-[2-(2-Benzylsulfanyl-ethanesulfonyl)-ethoxycarbonylamino]-3-phenyl-propionic acid tert-butyl ester
  参考文献：
  名称：

  A Cleavable Amino−Thiol Linker for Reversible Linking of Amines to DNA

  摘要：

  A cleavable heterobifunctional cross-linker for the reversible conjugation of amines to thiol-modified DNA has been developed and tested. The succinimidyl 2-(vinylsulfonyl)-ethyl carbonate (SVEC) was prepared in three steps and tested for its ability to react with amines and thiols. The linker was efficient for binding leucine to a thiol-modified DNA sequence and for releasing the amino acid at pH 11.8.

  DOI：

  10.1021/jo0619736
• 作为产物：
  描述：

  succinimidyl 2-vinylsulfanylethyl carbonate 在 过氧乙酸 、 溶剂黄146 作用下， 反应 2.5h， 以82%的产率得到碳酸2,5-二氧代-1-吡咯烷基2-(乙烯基磺酰基)乙酯
  参考文献：
  名称：

  A Cleavable Amino−Thiol Linker for Reversible Linking of Amines to DNA

  摘要：

  A cleavable heterobifunctional cross-linker for the reversible conjugation of amines to thiol-modified DNA has been developed and tested. The succinimidyl 2-(vinylsulfonyl)-ethyl carbonate (SVEC) was prepared in three steps and tested for its ability to react with amines and thiols. The linker was efficient for binding leucine to a thiol-modified DNA sequence and for releasing the amino acid at pH 11.8.

  DOI：

  10.1021/jo0619736

文献信息

• [EN] COMPOUNDS, DEVICES, AND USES THEREOF<br/>[FR] COMPOSÉS, DISPOSITIFS ET UTILISATIONS ASSOCIÉES
  申请人：SIGILON THERAPEUTICS INC

  公开号：WO2018067615A1

  公开（公告）日：2018-04-12

  The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.

  本发明提供化合物，例如，具有式（I）的化合物和药用可接受的盐、溶剂化合物、水合物、互变异构体、立体异构体、同位素标记衍生物及其组合物。还提供包括相同化合物的可植入元件（例如，设备和材料），以及使用方法，例如，用于治疗或预防疾病、紊乱或状况。
• MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES
  申请人：Harth Eva M.

  公开号：US20090306335A1

  公开（公告）日：2009-12-10

  In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及聚合物、交联聚合物、功能化聚合物、纳米颗粒和功能化纳米颗粒以及其制备和使用方法。其中，本发明涉及可降解聚合物和可降解纳米颗粒。本发明还涉及制备可降解纳米颗粒的方法，更具体地说，涉及在制备可降解纳米颗粒过程中控制颗粒大小的方法。在一方面，这些可降解纳米颗粒可用于复合、传递和释放药物活性载荷等方面。本摘要旨在作为搜索特定技术领域的扫描工具，不限制本发明。
• Multifunctional Degradable Nanoparticles with Control over Size and Functionalities
  申请人：Harth Eva M.

  公开号：US20110257343A1

  公开（公告）日：2011-10-20

  In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  一方面，本发明涉及聚合物、交联聚合物、功能化聚合物、纳米颗粒和功能化纳米颗粒的制备和使用方法。另一方面，本发明涉及可降解聚合物和可降解纳米颗粒。另一方面，本发明涉及制备可降解纳米颗粒的方法，更具体地说，涉及在制备可降解纳米颗粒过程中控制颗粒大小的方法。另一方面，可降解纳米颗粒可用于复合、传递和释放药物活性载荷等用途。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• Multifunctional degradable nanoparticles with control over size and functionalities
  申请人：Vanderbilt University

  公开号：US10442890B2

  公开（公告）日：2019-10-15

  In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  一方面，本发明涉及聚合物、交联聚合物、功能化聚合物、纳米颗粒和功能化纳米颗粒以及制造和使用它们的方法。一方面，本发明涉及可降解聚合物和可降解纳米颗粒。一方面，本发明涉及制备可降解纳米颗粒的方法，更具体地说，涉及在制备可降解纳米颗粒过程中控制粒径的方法。在一个方面，可降解纳米颗粒可用于络合、输送和释放有效载荷，包括药物活性有效载荷。本摘要旨在作为一种扫描工具，用于在特定技术领域进行搜索，并非对本发明的限制。
• Hansen, Margit Haahr; Blakskjaer, Peter; Petersen, Lars Kolster, Journal of the American Chemical Society, 2009, vol. 131, p. 1322 - 1327
  作者：Hansen, Margit Haahr、Blakskjaer, Peter、Petersen, Lars Kolster、Hansen, Tara Heitner、Hooejfeldt, Jonas Westergaard、et al.

  DOI：——

  日期：——