dichloro(p-ethyl-phenyl)phosphine | 5274-50-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichloro(p-ethyl-phenyl)phosphine
• 英文别名: 4-Aethylphenylphosphondichlorid；<4-Aethyl-phenyl>-dichlor-phosphin；(4-ethyl-phenyl)-dichloro-phosphine；(4-Aethyl-phenyl)-dichlor-phosphin；(4-ethylphenyl)-phosphonous dichloride；p-Ethylphenyldichlorophosphine；dichloro-(4-ethylphenyl)phosphane
• CAS: 5274-50-0
• 化学式: C₈H₉Cl₂P
• 分子量: 207.039
• InChiKey: LPRCGYFPWJEAEV-UHFFFAOYSA-N

物化性质

• 沸点：
  251°C
• 密度：
  1.2370

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloro(p-ethyl-phenyl)phosphine 在 二氧化硫 、 水 、 氯 作用下， 生成 (4-Aethyl-phenyl)-phosphonsaeure
  参考文献：
  名称：

  Michaelis, Justus Liebigs Annalen der Chemie, 1896, vol. 293, p. 292

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 三氯化磷 作用下， 生成 dichloro(p-ethyl-phenyl)phosphine
  参考文献：
  名称：

  关于芳基二氯膦II

  摘要：

  描述了通过较早给出的方法制备一些二氯膦。

  DOI：

  10.1002/hlca.19530360612

文献信息

• AlCl3-catalyzed C-H p hosphination of benzene: A mechanistic study
  作者：Haodong Duan、Xiaolei Xu、Kangwei Leng、Ge Guo、Qing Yu、Xinjin Li、Yuxi Han、Jun Gao、Zhongwei Wang

  DOI：10.1016/j.apcata.2020.117943

  日期：2021.2

  reacted with PCl3 to form DCPP-AlCl3, and DCPP-AlCl3 dissociated into DCPP and AlCl3, continuing to catalyze this reaction. This resulted in the high catalytic efficiency of AlCl3. The layering of the reaction solution was caused by the immiscibility of DCPP-AlCl3 with the raw materials, greatly facilitating the dissociation process of DCPP-AlCl3. The formation of diphenylphosphorus chloride (DPC) was due

  研究了在AlCl 3存在下经由苯和PCl 3制备二氯苯基膦（DCPP）的反应特性。当使用催化量的AlCl 3时，观察到一些独特的特征。即，相对于每摩尔AlCl 3获得多于1摩尔的DCPP ，将反应溶液分层，并且可以直接分离DCPP。我们的机理研究表明，苯与PCl 3反应形成DCPP-AlCl 3，并且DCPP-AlCl 3解离为DCPP和AlCl 3，继续催化该反应。这导致AlCl 3的高催化效率。反应溶液的分层是由于DCPP-AlCl 3与原料的不混溶引起的，极大地促进了DCPP-AlCl 3的离解过程。氯化二苯基磷（DPC）的形成是由于DCPP与苯之间的连续Friedel-Crafts反应。DPC与AlCl 3共同形成稳定的配位化合物DPC-AlCl 3，该化合物不会解离，并负责AlCl 3的失活。
• An Improved Method of Synthesis of Aromatic Dichlorophosphines¹
  作者：Bernard Buchner、Luther B. Lockhart

  DOI：10.1021/ja01146a076

  日期：1951.2
• Jones et al., Journal of the Chemical Society, 1947, p. 1446,1449
  作者：Jones et al.

  DOI：——

  日期：——
• Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma
  作者：Rakesh K Kumar、Paul S Thomas、Da-Qiang Seetoo、Cristan Herbert、Andrew N J McKenzie、Paul S Foster、Andrew R Lloyd

  DOI：10.1038/labinvest.3780442

  日期：2002.4

  Chemoattractants such as eotaxin are believed to play an important role in the recruitment of eosinophils into the airways in asthma. We investigated expression of eotaxin in the airway wall in a model of chronic human asthma, in which systemically sensitized mice were exposed to low mass concentrations of aerosolized antigen for 6 weeks. In these animals, the number of intraepithelial eosinophils in the airways was significantly increased 3 hours after exposure and declined by 24 hours. In parallel, immunoreactivity for eotaxin was strikingly up-regulated in airway epithelial cells and in inflammatory cells in the lamina propria. The latter were identified as plasma cells by double immunofluorescent labeling. Increased expression of eotaxin by epithelial cells and plasma cells was also demonstrated in a case of fatal human asthma. In contrast, sensitized mice that received a single exposure to a high mass concentration of aerosolized antigen exhibited delayed eosinophil recruitment, which did not correlate with eotaxin expression. Furthermore, in sensitized chronically exposed interieukin-13-deficient mice there was virtually no recruitment of eosinophils into the airways, although eotaxin expression was greater than or equal to that in wild-type mice. These results indicate that there are striking differences between acute and chronic exposure models in the time course of eotaxin expression and eosinophil recruitment. Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis.
• Fǎgǎdar-Cosma, Eugenia; Fǎgǎdar-Cosma, Gheorghe; Ţǎranu, Ioan, Revue Roumaine de Chimie, 2001, vol. 46, # 10, p. 1133 - 1138
  作者：Fǎgǎdar-Cosma, Eugenia、Fǎgǎdar-Cosma, Gheorghe、Ţǎranu, Ioan、Iliescu, Smaranda、Grozav, Maţa

  DOI：——

  日期：——