methyl (3-(2-chloro-10H-phenothiazin-10-yl)propyl)carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: methyl (3-(2-chloro-10H-phenothiazin-10-yl)propyl)carbamate
• 英文别名: methyl N-[3-(2-chlorophenothiazin-10-yl)propyl]carbamate
• 化学式: C₁₇H₁₇ClN₂O₂S
• 分子量: 348.853
• InChiKey: DZNBLECTIOJCMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯吩噻嗪 在 盐酸 、 sodium hydride 、 三乙胺 、 肼 作用下， 以 1,4-二氧六环 、 乙醇 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 2.0h， 生成 methyl (3-(2-chloro-10H-phenothiazin-10-yl)propyl)carbamate
  参考文献：
  名称：

  Reengineered tricyclic anti-cancer agents

  摘要：

  The phenothiazine and dibenzazepine tricyclics are potent neurotropic drugs with a documented but underutilized anti-cancer side effect. Reengineering these agents (TFP, CPZ, CIP) by replacing the basic amine with a neutral polar functional group (e.g., RTC-1, RTC-2) abrogated their CNS effects as demonstrated by in vitro pharmacological assays and in vivo behavioral models. Further optimization generated several phenothiazines and dibenzazepines with improved anti-cancer potency, exemplified by RTC-5. This new lead demonstrated efficacy against a xenograft model of an EGFR driven cancer without the neurotropic effects exhibited by the parent molecules. Its effects were attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.07.007

文献信息

• TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
  申请人：Ohlmeyer Michael

  公开号：US20140213578A1

  公开（公告）日：2014-07-31

  Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following phenothiazine, dibenzoazepine and annulene and similar genera:

  本文披露了三环化学调节剂对FOXO转录因子蛋白的调节作用。这些化合物可用于治疗癌症、年龄相关蛋白质毒性、压力引起的抑郁症、炎症和痤疮。这些化合物属于以下苯硫噻嗪、二苯并氮杂环和环戊烯类似物系列：
• [EN] TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS<br/>[FR] COMPOSÉS TRICYCLIQUES EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：MT SINAI SCHOOL OF MEDICINE

  公开号：WO2013025882A3

  公开（公告）日：2013-04-25
• Motohashi, Noboru; Kawase, Masami; Molnar, Joseph, Arzneimittel-Forschung/Drug Research, 2003, vol. 53, # 8, p. 590 - 599
  作者：Motohashi, Noboru、Kawase, Masami、Molnar, Joseph、Ferenczy, Lajos、Wesolowska, Olga、Hendrich, Andrzej B.、Bobrowska-Haegerstrand, Malgorzata、Haegerstrand, Henry、Michalak, Krystyna

  DOI：——

  日期：——
• US9540358B2
  申请人：——

  公开号：US9540358B2

  公开（公告）日：2017-01-10