7-methoxy-6-(3'-N-morpholino)propoxyquinazoline | 1208902-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline
• 英文别名: 4-(3-((7-Methoxyquinazolin-6-yl)oxy)propyl)morpholine；4-[3-(7-methoxyquinazolin-6-yl)oxypropyl]morpholine
• CAS: 1208902-96-8
• 化学式: C₁₆H₂₁N₃O₃
• 分子量: 303.361
• InChiKey: NSLPTLVLAULCPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-methoxy-6-(3'-N-morpholino)propoxyquinazoline 在 过氧乙酸 、 硫酸 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以85%的产率得到7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮
  参考文献：
  名称：

  Facile and Efficient Oxidation of Quinazolines into Quinazolin-4(3H)-ones by Peracetic Acid

  摘要：

  A new approach to synthesize quinazoline-4(3H)-ones was achieved by oxidation of quinazolines using peracetic acid, which possesses some advantages of economic reagents, simplified operation, high efficiency, and environmental friendliness. Application of this method allowed us to synthesize a series of quinazolin-4(3H)-ones with different substituents at 6 and 7 positions in good to excellent yields, including the key intermediates of tyrosine kinase inhibitors such as PD153035, Erlotinib, and Gefitinib. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.805230
• 作为产物：
  描述：

  5-苄氧基-4-甲氧基-2-硝基苯甲醛 在 盐酸 、 palladium on activated charcoal 、 氢气 、 铁粉 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline
  参考文献：
  名称：

  Facile and Efficient Oxidation of Quinazolines into Quinazolin-4(3H)-ones by Peracetic Acid

  摘要：

  A new approach to synthesize quinazoline-4(3H)-ones was achieved by oxidation of quinazolines using peracetic acid, which possesses some advantages of economic reagents, simplified operation, high efficiency, and environmental friendliness. Application of this method allowed us to synthesize a series of quinazolin-4(3H)-ones with different substituents at 6 and 7 positions in good to excellent yields, including the key intermediates of tyrosine kinase inhibitors such as PD153035, Erlotinib, and Gefitinib. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.805230

文献信息

• A novel approach to quinazolin-4(3H)-one via quinazoline oxidation: an improved synthesis of 4-anilinoquinazolines
  作者：Giovanni Marzaro、Adriano Guiotto、Giovanni Pastorini、Adriana Chilin

  DOI：10.1016/j.tet.2009.11.091

  日期：2010.1

  A novel strategy to prepare 4-anilinoquinazoline derivatives based on the oxidation of the quinazoline ring is described. Quinazoline oxidation has been investigated and improved, thus leading to an efficient and high yielding method to quinazolin-4(3H)-ones. Efficiency of this approach has been evaluated synthesizing four well known tyrosine kinase inhibitors and comparing the obtained yields with those achievable through conventional synthetic methods. (C) 2009 Elsevier Ltd. All rights reserved.