4-甲基-N-[4-[4-[(4-甲基-2,6-二氧代-3H-嘧啶-5-基)磺酰基氨基]苯基]磺酰基苯基]-2,6-二氧代-3H-嘧啶-5-磺酰胺 | 34941-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-甲基-N-[4-[4-[(4-甲基-2,6-二氧代-3H-嘧啶-5-基)磺酰基氨基]苯基]磺酰基苯基]-2,6-二氧代-3H-嘧啶-5-磺酰胺
• 英文名称: 4,4'-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidinyl-5-sulfonylamido)diphenylsulfone
• 英文别名: p,p'-bis(2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidyl-5-sulfonamido)diphenylsulfone；diutsifon；Diucifon；6-methyl-N-[4-[4-[(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)sulfonylamino]phenyl]sulfonylphenyl]-2,4-dioxo-1H-pyrimidine-5-sulfonamide
• CAS: 34941-71-4
• 化学式: C₂₂H₂₀N₆O₁₀S₃
• 分子量: 624.633
• InChiKey: DVAIYSZTXVOUQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  268
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  4-甲基-N-[4-[4-[(4-甲基-2,6-二氧代-3H-嘧啶-5-基)磺酰基氨基]苯基]磺酰基苯基]-2,6-二氧代-3H-嘧啶-5-磺酰胺 、 双氧水 生成 氨苯砜
  参考文献：
  名称：

  NUZHNOVA, N. I.;SHASHINA, I. V., MATER. 5 BCEPOC. SEZDA FARMATSEVTOV, YAROSLAVL, 15-16 CEHT., 1987. TEZ. D+

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基尿嘧啶 、 alkaline earth salt of/the/ methylsulfuric acid 在 氯磺酸 、 氯化亚砜 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 49.0h， 生成 4-甲基-N-[4-[4-[(4-甲基-2,6-二氧代-3H-嘧啶-5-基)磺酰基氨基]苯基]磺酰基苯基]-2,6-二氧代-3H-嘧啶-5-磺酰胺
  参考文献：
  名称：

  Study of the technology of diutsifon synthesis

  摘要：

  DOI：

  10.1007/bf02524582

文献信息

• METHODS AND DEVICES FOR COMPOUND DELIVERY
  申请人：E-Nicotine Technology, Inc.

  公开号：EP2925395A1

  公开（公告）日：2015-10-07
• METHODS AND DEVICES FOR SMOKING URGE RELIEF
  申请人：Fontem Holdings 1 B.V.

  公开号：EP3096636A1

  公开（公告）日：2016-11-30
• METHODS FOR THE TREATMENT OF MYCOBACTERIUM INFECTIONS
  申请人：University of South Florida

  公开号：US20220016075A1

  公开（公告）日：2022-01-20

  The present disclosure provides methods for the treatment of infections with Mycobacterium such as tuberculosis or leprosy.
• [EN] ALKALINE SALTS ON N-(6-ALKYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINESULFONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH CAN POSSESS ANTIMICROBIAL AND IMMUNOTHROPE ACTIVITY, THE METHOD FOR PRODUCING THESE SALTS, THEIR USE AS IMMUNOMODULATOR AND PHARMACEUTICAL COMPOSITION BASED ON THESE SALTS<br/>[FR] SELS ALCALINS DE N-(6-ALKYLE-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINESULFONE)-N'-ISONICOTINOYLHYDRAZIDE POUVANT PRESENTER UNE ACTIVITE ANTIMICROBIENNE ET IMMUNOTROPE, METHODE DE PREPARATION DE CES SELS, UTILISATION DE CES SELS COMME IMMUNOMODULATEURS ET COMPOSITION PHARMACEUTIQUE A BASE DE CES SELS
  申请人：RESHETOV ALEXANDR LEONIDOVICH

  公开号：WO2001032650A2

  公开（公告）日：2001-05-10

  Alkaline salts of N-(6-alkyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfone)-N'-isonicotinoylhydrazide of formula (I), where R is 1-4 carbon atoms alkyl and M is alkali metal, which can possess antimicrobial and immunothrope activities and can be used as immunomodulator are offered, as well as the method for producing these salts and pharmaceutical composition based on them. The offered salts may be used in treating chronic recurring diseases complicated with bacterial infections on the immunodeficiency background, also they may be used as antimicrobial means.
• [EN] METHODS AND DEVICES FOR COMPOUND DELIVERY<br/>[FR] PROCÉDÉS ET DISPOSITIFS POUR L'ADMINISTRATION DE COMPOSÉS
  申请人：NICOTINE TECHNOLOGY INC E

  公开号：WO2014085719A1

  公开（公告）日：2014-06-05

  Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation.