N-carboxy anhydride of L-glutamic acid γ-methyl ester | 1663-47-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-carboxy anhydride of L-glutamic acid γ-methyl ester
• 英文别名: N-(carboxyanhydride) of γ-methyl glutamate；γ-methyl L-glutamate-N-carboxy anhydride；γ-methyl glutamate N-carboxyanhydride；3-(2,5-dioxo-oxazolidin-4-yl)-propionic acid methyl ester；N-carboxy-glutamic acid 1,2-anhydride 5-methyl ester；(+/-)-3-(2,5-dioxo-oxazolidin-4-yl)-propionic acid methyl ester；Methyl 2,5-dioxooxazolidine-4-propionate；methyl 3-(2,5-dioxo-1,3-oxazolidin-4-yl)propanoate
• CAS: 1663-47-4；7445-27-4；1676-88-6
• 化学式: C₇H₉NO₅
• 分子量: 187.152
• InChiKey: JRZZMWDRALHNFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  5-甲氧基色胺 、 N-carboxy anhydride of L-glutamic acid γ-methyl ester 以 1,4-二氧六环 为溶剂， 以65%的产率得到
  参考文献：
  名称：

  Suvorov, N. N.; Popova, G. V.; Neklyudov, A. D., Journal of general chemistry of the USSR, 1982, vol. 52, # 10, p. 2079 - 2083

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 COCl₂ 作用下， 生成 N-carboxy anhydride of L-glutamic acid γ-methyl ester
  参考文献：
  名称：

  Lautsch; Schroeder, Zeitschrift fur Naturforschung, 1954, vol. 9b, p. 277,287

  摘要：

  DOI：

文献信息

• [EN] PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE<br/>[FR] PROCÉDÉS DE PRÉPARATION DE (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
  申请人：CELGENE CORP

  公开号：WO2019040109A1

  公开（公告）日：2019-02-28

  Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

  提供了制备(S)-叔丁基4,5-二氨基-5-氧代戊酸酯，或其盐、溶剂结晶体、水合物、对映体、对映体混合物或同位素类似物的方法。还提供了从这些过程中获得的各种中间体和产物的固体形式。
• Preparation of a Novel Aggregate Like Sugar-Ball Micelle Composed of Poly(methylglutamate) and Poly(ethyleneglycol) Modified by Lactose and Its Molecular Recognition by Lectin.
  作者：Akiko TOYOTAMA、Shin-ichi KUGIMIYA、Junpei YAMANAKA、Masakatsu YONESE

  DOI：10.1248/cpb.49.169

  日期：——

  We report the preparation and characteristics of a novel micellar aggregate of an amphiphilic diblock copolymer, poly(methylglutamate) (PMG)-poly(ethyleneglycol) (PEG), whose terminus was modified by lactose lactone (LA). Due to the terminal LA moiety, this aggregate could be specifically recognized by RCA120 lectin. PMG-PEG-LA was synthesized by polymerizing the N-carboxy anhydride of L-glutamic acid γ-methyl ester with H2N-PEG-LA as a polymerization initiator. By applying a fluorescence method using pyrene as a probe molecule, we found that PMG-PEG-LA could form the aggregate in aqueous solution. Fluorescence measurements showed that the critical aggregation concentration (C.A.C.) was 1.1×10-5 M. The average diameter of the aggregate was 220 nm at 25 °C, as determined by the dynamic light scattering method. Circular dichroism measurements for the aggregate solution showed that the PMG residue took an α-helical structure, and that they associated to constitute the hydrophobic core of the aggregate. By adding RCA120 lectin to the aggregate solution, the turbidity of the solution increased rapidly, due to association of the aggregates. This implies that the aggregate could be recognized by lectin, and also suggests that sugar residues locate at the surface of the aggregates. From these findings, we concluded that the PMG-PEG-LA molecules form an aggregate like a “sugar ball” micelle, whose surface is covered by the sugar moieties. Application of the present aggregate system as a drug carrier is briefly discussed.

  我们报告了一种新型胶束聚合体的制备方法和特点，这种聚合体是一种两亲性二嵌段共聚物，即聚（谷氨酸甲酯）（PMG）-聚（乙二醇）（PEG），其末端由乳糖内酯（LA）修饰。由于末端有 LA 分子，RCA120 凝集素能特异性地识别这种聚合体。PMG-PEG-LA是以H2N-PEG-LA为聚合引发剂，通过聚合L-谷氨酸γ-甲酯的N-羧基酸酐而合成的。通过以芘为探针分子的荧光方法，我们发现 PMG-PEG-LA 可以在水溶液中形成聚合体。荧光测量显示临界聚集浓度（C.A.C.）为 1.1×10-5 M。聚合体溶液的圆二色性测量结果表明，PMG残基具有α-螺旋结构，它们共同构成了聚合体的疏水核心。在聚合体溶液中加入 RCA120 凝集素后，由于聚合体的结合，溶液的浊度迅速增加。这意味着聚合体能被凝集素识别，也表明糖残基位于聚合体的表面。根据这些发现，我们得出结论，PMG-PEG-LA 分子形成的聚集体就像一个 "糖球 "胶束，其表面被糖分子覆盖。本文简要讨论了本聚合体系统作为药物载体的应用。
• Novel amphiphilic substance, and drug delivery system and molecular imaging system using the same
  申请人：Akitsu Hitoshi

  公开号：US20080019908A1

  公开（公告）日：2008-01-24

  The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.

  本发明提供了一种新型的两性物质，使用这种新型两性物质制备的纳米粒子可用作具有高生物相容性的纳米载体，药物传递系统以及用于该系统的探针，以及分子成像系统和用于该系统的探针。其中，该两性块聚合物包括一个亲水块；和一个疏水块，其中亲水块是具有10个或更多砒氨酸单元的亲水多肽链，而疏水块是包含氨基酸单元和羟基酸单元等基本结构单元中选择的单位的疏水分子链，并且具有5个或更多基本结构单元。
• PROCESS FOR THE PREPARATION OF COPOLYMER - 1 (COP-1), COMPOSED OF L-ALANINE, L-LYSINE, L-GLUTAMIC ACID AND L-TYROSINE-DRUG FOR THE TREATMENT OF MULTIPLE SCLEROSIS
  申请人：Garnaik Baijayantimala

  公开号：US20120077952A1

  公开（公告）日：2012-03-29

  A process for the synthesis of copolymer-1 composed of L-alanine, LHysine, L-glutamic acid and L-tyrosine for the treatment of multiple sclerosis. The molecular weight of copolymer-1 is between 8-19 KDa. Process is initiated by supported dialkyl amine. The copolymer-1 of the invention has acid content of less than 1%.
• COMPOUND AND METHOD FOR PRODUCING THE SAME
  申请人：PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US20210130408A1

  公开（公告）日：2021-05-06

  Disclosed is a method for producing a compound, the method including polymerizing an amino acid carboxyanhydride-based compound using a catalyst. The method for producing the compound may improve a polymerization reaction rate and provide a compound having a narrower molecular weight distribution and having a polymer ring structure bonded to the catalyst.

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