3,3',3'',3'''-(乙烯二次氮基)四丙腈 | 45243-86-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3,3',3'',3'''-(乙烯二次氮基)四丙腈
• 英文名称: N,N,N',N'-tetrakis(2-cyanoethyl)-1,2-ethylenediamine
• 英文别名: N,N,N',N'-tetra(2-cyanoethyl)ethane-1,2-diamine；N,N,N′,N′-tetrakis(2-cyanoethyl)-1,2-ethylenediamine；N,N,N'-tetrakis(2-cyanoethyl)1,2-diaminoethane；ethylenediaminetetrapropionitrile；3,3',3'',3'''-ethanediyldiimino-tetra-propionitrile；3,3',3'',3'''-Aethandiyldiimino-tetra-propionitril；Tetrakis-N-(2-cyan-aethyl)-aethylendiamin；N,N,N',N'-tetrakis(cyanoethyl)ethylenediamine；EDTPN；3,3',3",3'"-(ethane-1,2-diylbis(azanetriyl))tetrapropanenitrile；N,N,N',N'-tetrakis(2-cyanoethyl)ethylenediamine；Propanenitrile, 3,3',3'',3'''-(1,2-ethanediyldinitrilo)tetrakis-；3-[2-[bis(2-cyanoethyl)amino]ethyl-(2-cyanoethyl)amino]propanenitrile
• CAS: 45243-86-5
• 化学式: C₁₄H₂₀N₆
• 分子量: 272.353
• InChiKey: MXHIGVLOGPIQHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  3,3',3'',3'''-(乙烯二次氮基)四丙腈 在 羟胺 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以76.4%的产率得到3,3',3",3'"-(ethane-1,2-diylbis(azanetiyl))tetrakis(N'-hydroxypropanimidamide)
  参考文献：
  名称：

  STABILIZATION OF HYDROXYLAMINE CONTAINING SOLUTIONS AND METHOD FOR THEIR PREPARATION

  摘要：

  本发明涉及将酰胺肟用于预防或稳定羟基胺化合物，防止其不受控分解。

  公开号：

  US20090112024A1
• 作为产物：
  描述：

  乙二胺 、 丙烯腈 以 水 为溶剂， 反应 45.0h， 以93%的产率得到3,3',3'',3'''-(乙烯二次氮基)四丙腈
  参考文献：
  名称：

  N,N,N',N'-四(2-腈乙基)乙烷-1,2-二胺和N-(2-腈乙基)苄胺氢溴酸盐的晶体和分子结构

  摘要：

  N,N,N',N'-四(2-腈乙基)乙烷-1,2-二胺和N-(2-腈乙基)苄胺氢溴酸盐通过丙烯腈与相应胺的加成反应制备，两种结构分别为由 X 射线单晶衍射测定。两种化合物均以单斜晶系结晶，两种晶体结构中几乎不存在经典的氢键。

  DOI：

  10.1007/s10947-006-0312-x

文献信息

• NOVEL NITRILE AND AMIDOXIME COMPOUNDS AND METHODS OF PREPARATION
  申请人：Lee Wai Mun

  公开号：US20090111965A1

  公开（公告）日：2009-04-30

  The present application relates to semiconductor processing compositions comprising at least one compound containing at least one amidoxime functional group and to methods of using these compositions in semiconductor processing. The present application also describes the preparation of amidoximes for a semiconductor processing composition by (a) mixing a cyanoethylation catalyst, a nucleophile and an alpha-unsaturated nitrile to produce a cyanoethylation product; and (b) converting a cyano group in the cyanoethylation product into an amidoxime functional group.

  本申请涉及包含至少一个含有至少一个酰胺肟功能团的化合物的半导体加工组合物，以及使用这些组合物进行半导体加工的方法。本申请还描述了通过(a)混合氰乙基化催化剂、亲核试剂和不饱和α腈以产生氰乙基化产品；(b)将氰乙基化产品中的氰基团转化为酰胺肟功能团来制备用于半导体加工组合物的酰胺肟的方法。
• Poly(hydroxamic acid) functionalized copper catalyzed C–N bond formation reactions
  作者：Md. Shaharul Islam、Bablu Hira Mandal、Tapan Kumar Biswas、Md. Lutfor Rahman、S. S. Rashid、Suat-Hian Tan、Shaheen M. Sarkar

  DOI：10.1039/c6ra08155j

  日期：——

  Highly active poly(hydroxamic acid) functionalized copper catalysts were synthesized by the surface modification of khaya cellulose through graft copolymerization and subsequent hydroximation processes. The prepared catalysts were well characterized by FTIR, FESEM, HRTEM, ICP-AES, UV-vis and XPS analyses. The supported catalysts effectively promoted C–N bond formation reactions and provided excellent

  通过接枝共聚和随后的加氢脱氧过程对khaya纤维素进行表面改性，合成了高活性的聚（异羟肟酸）官能化铜催化剂。FTIR，FESEM，HRTEM，ICP-AES，UV-vis和XPS分析对制备的催化剂进行了很好的表征。在温和的反应条件下，负载型催化剂有效地促进了C–N键的形成反应，并提供了优异的产率。催化剂易于从反应混合物中回收，并且可以重复使用数次，而其催化活性没有任何重大损失。
• Iodine-Alumina Catalyzed Aza- Michael Addition under Solvent Free Conditions
  作者：Monmi Saikia、Dwipen Kakati、Maria Joseph、Jadab Sarma

  DOI：10.2174/157017809790442961

  日期：2009.12.1

  An efficient aza-Michael addition of amines to a variety of activated olefins was carried out under solvent free conditions using iodine-alumina as a catalyst at room temperature or under microwave irradiation (in case of solid) in high yield.

  在无溶剂条件下，利用碘-氧化铝作为催化剂，在室温或微波辐照（针对固体情况）下，胺类物质对多种活化烯烃进行了一次高效迈克尔加成反应，产率极高。
• Green synthesis of CuO nanoparticles using <i>Lantana camara</i> flower extract and their potential catalytic activity towards the aza-Michael reaction
  作者：Rakesh Chowdhury、Aslam Khan、Md. Harunar Rashid

  DOI：10.1039/d0ra01479f

  日期：——

  An easy and convenient synthesis process is reported for the synthesis of CuO nanoparticles using plant extract for use as a catalyst in the aza-Michael addition reaction.

  报道了一种使用植物提取物合成CuO纳米颗粒的简单方便合成过程，用作aza-Michael加成反应中的催化剂。
• Surface Engineered Dendrimers as Antiangiogenic Agent and Carrier for Anticancer Drug: Dual Attack on Cancer
  作者：K. Jain、N. K. Jain

  DOI：10.1166/jnn.2014.8677

  日期：2014.7.1

  The present research work describes the formulation of arginine conjugated 3.0G Poly(propylene) imine (PPI) dendrimers, mimicking the surface structure of an endogenous angiogenesis-inhibitor endostatin; for tumor specific delivery of a model anticancer drug, doxorubicin hydrochloride (Dox). Synthesis of PPI dendrimers and conjugation of arginine to surface groups was confirmed by FTIR, NMR, TEM and mass spectrometry. Drug was loaded by equilibrium dialysis method and developed formulation was evaluated for entrapment efficiency, hemolytic toxicity, in vitro drug release, stability, anti-angiogenic activity via in vivo chick embryo chorioallantoic membrane (CAM) assay, and anticancer activity and cell uptake using MCF-7 cancer cell lines. The system exhibited the initial rapid release followed by sustained release of Dox with significant antiangiogenic activity in the CAM assay. Further, the arginine conjugated dendrimers was found to inhibit growth of cancer cells in ex vivo studies with MCF-7 cell lines. Cell uptake studies suggested that in comparison to free drug the formulation was preferably taken up by the tumor cells. Thus the two pronged attack on cancerous tissue i.e., inhibition of angiogenesis and killing of cancer cells by anticancer drug, might prove to be a promising approach in the treatment of fatal disease, cancer.

  本研究工作描述了模拟内源性血管生成抑制剂内皮抑素表面结构的精氨酸偶联3.0G聚(丙烯)亚胺(PPI)树枝状大分子的制备，用于肿瘤特异性传递模型抗癌药物盐酸多柔比星(Dox)。通过FTIR、NMR、TEM和质谱法确认了PPI树枝状大分子的合成以及精氨酸与表面基团的 conjugation。通过平衡透析方法加载药物，并评估所开发的制剂的包封效率、溶血毒性、体外药物释放、稳定性、通过体内鸡胚绒毛尿囊膜(CAM)试验评估的抗血管生成活性，以及使用MCF-7癌细胞系进行的抗癌活性和细胞摄取。该系统表现出初始的快速释放随后持续释放Dox，并在CAM试验中显示出显著的抗血管生成活性。此外，精氨酸偶联的树枝状大分子在体内研究中被发现能抑制MCF-7细胞系的癌细胞生长。细胞摄取研究表明，与自由药物相比，制剂更优先被肿瘤细胞摄取。因此，针对癌细胞组织的两种攻击方式，即抑制血管生成和通过抗癌药物杀灭癌细胞，可能成为治疗致命疾病癌症的有前景的方法。