5-diethylamino-2-methylpentene | 216174-30-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-diethylamino-2-methylpentene
• 英文别名: diethyl-(4-methyl-pent-4-enyl)-amine；Diaethyl-(4-methyl-pent-4-enyl)-amin；5-Dimethylamino-2-methyl-penten-(1)；N,N-diethyl-4-methylpent-4-en-1-amine
• CAS: 216174-30-0
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: YZQBKWGYGQORPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-氯-4-碘喹啉 、 5-diethylamino-2-methylpentene 在 9-硼双环[3.3.1]壬烷 、 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以72%的产率得到5-(7-chloroquinolin-4-yl)-N,N-diethyl-4-methylpentan-1-amine
  参考文献：
  名称：

  Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine:  Effects on pK_a, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth

  摘要：

  Unlike diprotic chloroquine (CQ), its two 4-aminoquinoline carbon isosteres (1, 2) are monoprotic at physiological pH. Compared to CQ, hematin binding affinity of 1 decreased 6.4-fold, and there was no measurable binding for 2. Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falciparum in vitro. Evidently, the CQ-hematin interaction is largely a function of its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-aminopyridine substructure.

  DOI：

  10.1021/jm030038x
• 作为产物：
  描述：

  5-氯-2-戊酮 在 正丁基锂 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 19.0h， 生成 5-diethylamino-2-methylpentene
  参考文献：
  名称：

  Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine:  Effects on pK_a, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth

  摘要：

  Unlike diprotic chloroquine (CQ), its two 4-aminoquinoline carbon isosteres (1, 2) are monoprotic at physiological pH. Compared to CQ, hematin binding affinity of 1 decreased 6.4-fold, and there was no measurable binding for 2. Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falciparum in vitro. Evidently, the CQ-hematin interaction is largely a function of its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-aminopyridine substructure.

  DOI：

  10.1021/jm030038x

文献信息

• PYRAZOLOPYRIDINE COMPOUND AS RET INHIBITOR AND APPLICATION THEREOF
  申请人：Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

  公开号：EP3950685A1

  公开（公告）日：2022-02-09

  Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

  本发明公开了一系列吡唑并吡啶化合物及其在制备治疗用 RET 激酶抑制剂中的应用。具体公开了式 (I) 所代表的化合物或其药学上可接受的盐。
• N-substituted phthalimides and their synthesis
  申请人：LILLY CO ELI

  公开号：US02432905A1

  公开（公告）日：1947-12-16
• Unsaturated amines and process for making same
  申请人：LILLY CO ELI

  公开号：US02409287A1

  公开（公告）日：1946-10-15
• THE CONVERSION OF QUATERNARY PYRROLIDINIUM SALTS TO OPEN-CHAIN DIAMINES
  作者：M. S. KHARASCH、CHARLES F. FUCHS

  DOI：10.1021/jo01186a008

  日期：1944.7