2-(vinyloxy)phenol | 58981-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(vinyloxy)phenol
• 英文别名: 2-ethenyloxyphenol；Brenzcatechin-monovinylaether；Vinyl-(2-oxy-phenyl)-aether；2-Vinyloxy-phenol；Catechol-monovinylaether；2-(Ethenyloxy)phenol；2-ethenoxyphenol
• CAS: 58981-47-8
• 化学式: C₈H₈O₂
• 分子量: 136.15
• InChiKey: AACJJTBDGOLJLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(vinyloxy)phenol 在 三甲基铝 、 potassium carbonate 作用下， 以 乙二醇二甲醚 、 正己烷 、 甲苯 为溶剂， 反应 31.0h， 生成 2-(1-(2-(vinyloxy)phenoxy)ethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

  摘要：

  We recently reported that the alpha(2)-adrenoreceptor (AR) ligand allyphenyline (9) significantly enhanced morphine analgesia (due to its alpha(2C)-AR agonism), was devoid of sedative side effects (due to its alpha(2A)-AR antagonism), prevented and reversed morphine tolerance and dependence. To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and opioid addiction management, the allyl group of 9 was replaced by substituents of moderate steric bulk (MR) and positive or negative lipophilic (pi) and electronic (sigma) contributions in all the possible combinations. Effective novel alpha(2C)-agonists/alpha(2A)-antagonists (2, 3, 10, 12, and 17) were obtained. This study also demonstrated that contradictory combinations of the physicochemical parameters were similarly able to induce the alpha(2A)-activation. Since we had previously observed that the absolute configuration affected only the potency, but not the functional profile of the ligands, we hypothesized that the alpha(2A)-activation was governed by a ligand preferred conformation. From a structural overlay investigation it emerged that an extended conformation appeared to be associated with dual alpha(2C)-agonism/alpha(2A)-antagonism, whereas a folded conformation associated with alpha(2C)-/alpha(2A)-agonism. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.01.035
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 alkali 作用下， 生成 2-(vinyloxy)phenol
  参考文献：
  名称：

  v. Braun; Kirschbaum, Chemische Berichte, 1920, vol. 53, p. 1406

  摘要：

  DOI：

文献信息

• A general, selective synthesis of ω-hydroxyethenyl ethers
  作者：E Cabianca、F Chéry、P Rollin、A Tatibouët、O De Lucchi

  DOI：10.1016/s0040-4039(01)02195-5

  日期：2002.1

  A general selective synthesis of β-, γ- and δ-hydroxyethenyl ethers, a class of compounds containing two mutually reactive functionalities positioned at an interacting distance, is based on the reaction of diols with 1,2-bis-(phenylsulfonyl)ethylene (BPSE) followed by reductive elimination of the resulting β-phenylsulfonyl acetals with sodium amalgam.

  β-，γ-和δ-羟基乙烯基醚的一般选择性合成是基于二醇与1,2-双-（苯磺酰基）乙烯（ BPSE），然后用汞齐钠还原消除生成的β-苯基磺酰基缩醛。
• Reductive opening of carbohydrate phenylsulfonylethylidene (PSE) acetals
  作者：Florence Chéry、Elena Cabianca、Arnaud Tatibouët、Ottorino De Lucchi、Thisbe K. Lindhorst、Patrick Rollin

  DOI：10.1016/j.carres.2015.09.011

  日期：2015.11

  carbohydrate-derived phenylsulfonylethylidene (PSE) acetals show a different behavior in reductive desulfonylation than simple symmetrical acetals. Here we have investigated various SET-type reaction conditions in order to open PSE acetals regioselectively and to produce chiral omega-hydroxyethenyl ethers. Whereas sodium amalgam leads to a mixture of regioisomeric vinyl ethers besides the ethylidene acetal, samarium

  苯磺酰基亚乙基（PSE）缩醛在碳水化合物化学中是一个相对较新的保护基。但是，碳水化合物衍生的苯磺酰亚乙基（PSE）缩醛在还原性脱磺酰基反应中的行为与简单的对称缩醛不同。在这里，我们研究了各种SET型反应条件，以选择性地打开PSE缩醛并生产手性ω-羟基乙烯基醚。汞齐除亚乙缩醛外还产生了区域异构乙烯基醚的混合物，而碘化for则适合于区域选择性的开环。用七个不同的碳水化合物PSE乙缩醛（分别为1,3-二氧杂环己烷和1,3-二氧戊环类型）显示。
• Latex and its preparation
  申请人：Polymer Latex GmbH & Co. KG

  公开号：EP1408059A1

  公开（公告）日：2004-04-14

  A latex having a reduced amount of 4-phenylcyclohexene is obtainable by a process comprising reacting A) 30-90% by weight of at least one ethylenically unsaturated monomer; B) 70-10% by weight of a diene; C) 1-10% by weight of α,β-unsaturated carboxylic acids, carboxylic acid nitriles, carboxylic acid amides, or mixtures thereof; and D) an auxiliary, an additive or mixtures thereof; wherein the sum of A, B and C is 100% by weight. The reaction follows a gradient regime for components A and B. In the gradient regime, an amount added per unit time of one of components A or B continuously increases, while simultaneously an amount added per unit time continuously decreases for one of components A or B which does not undergo the continuous increase; with the proviso that a starting molar ratio of A to B is adjusted from a range of 0.15 - 0.95 or 1.05 - 6.66 through at least one discontinuous change in the amount added per unit time to a target molar ratio of A to B, in the range of 1.05 - 6.66 or 0.15 - 0.95, and thereafter the change in the amount added per unit time is made i) constantly for A and B, and/or ii) decreasingly for A and ascendingly for B, and/or iii) decreasingly for B and ascendingly for A, in any sequence, individually or in combination.

  一种 4-苯基环己烯含量降低的胶乳可通过以下工艺获得：A) 至少一种乙烯基不饱和单体 30-90%（重量）；B) 二烯 70-10%（重量）；C) α，β-不饱和羧酸、羧酸腈、羧酸酰胺或其混合物 1-10%（重量）；以及 D) 助剂、添加剂或其混合物；其中 A、B 和 C 的总和为 100%（重量）。在梯度反应中，单位时间内 A 或 B 组分之一的添加量持续增加，同时单位时间内 A 或 B 组分之一的添加量持续减少，而 A 或 B 组分之一的添加量不持续增加；但 A 与 B 的起始摩尔比从 0.15 - 0.95 或 1.05 - 6.66的范围内，通过至少一次不连续的单位时间添加量的变化，达到A与B的目标摩尔比，在1.05 - 6.66或0.15 - 0.95的范围内，此后，单位时间添加量的变化是：i) A和B的持续变化，和/或ii) A的递减和B的递增，和/或iii) B的递减和A的递增，以任何顺序，单独或组合进行。
• NOVEL FLUORINE-CONTAINING POLYMER
  申请人：Asahi Glass Company, Limited

  公开号：EP2065409A1

  公开（公告）日：2009-06-03

  The present invention provides a fluorinated polymer excellent in the crosslinking reactivity, crosslinked rubber physical properties and chemical resistance, and its crosslinked rubber. A fluorinated polymer comprising repeating units (a) based on at least one monomer selected from the group consisting of ethylenic unsaturated compounds each having a hydroxyphenyl group, repeating units (b) based on at least one fluoromonomer selected from the group consisting of tetrafluoroethylene, hexafluoropropylene, vinylidene fluoride, 3,3,3-trifluoropropene, 1,3,3,3-tetrafluoropropene, 1,1,2-trifluoroethylene, vinyl fluoride, 1,2-difluoroethylene and CF2=CF-O-Rf (wherein Rf is a C1-8 saturated perfluoroalkyl group or a perfluoro(alkoxyalkyl) group) and, if necessary, repeating units (c) based on at least one hydrocarbon monomer selected from the group consisting of ethylene, propylene and CH2=CH-O-R1.

  本发明提供了一种在交联反应性、交联橡胶物理性能和耐化学性方面性能优异的含氟聚合物及其交联橡胶。 1,3,3,3-四氟丙烯、1,1,2-三氟乙烯、氟化乙烯、1,2-二氟乙烯和 CF2=CF-O-Rf（其中 Rf 为 C1-8 饱和全氟烷基或全氟（烷氧基烷基）基团）组成的组中的至少一种氟单体为基础的重复单元（c），以及必要时以选自乙烯、丙烯和 CH2=CH-O-R1 组成的组中的至少一种烃单体为基础的重复单元（d）。
• Composition for film formation, film, production method of patterned substrate, and compound
  申请人：JSR Corporation

  公开号：US10053539B2

  公开（公告）日：2018-08-21

  A composition comprises a compound comprising a partial structure represented by formula (1) and comprising an intermolecular bond-forming group; and a solvent. X1 and X2 each independently represent a substituted or unsubstituted ring structure having 4 to 10 ring atoms constituted taken together with a spiro carbon atom and carbon atoms of an aromatic ring. R1 and R2 each independently represent a halogen atom, a hydroxy group, a nitro group or a monovalent organic group. a1 and a2 are each independently an integer of 0 to 8. n1 and n2 are each independently an integer of 0 to 2; k1 and k2 are each independently an integer of 0 to 8. A sum of k1 and k2 is no less than 1, and a sum of a1 and k1. A sum of a2 and k2 are no greater than 8.

  一种组合物包括由式（1）所代表的部分结构组成并含有分子间成键基团的化合物；以及一种溶剂。X1和X2各自独立地代表具有4至10个环原子的取代或未取代的环结构，这些环原子由螺碳原子和芳香环的碳原子共同构成。R1 和 R2 各自独立地代表卤素原子、羟基、硝基或一价有机基团；a1 和 a2 各自独立地为 0 至 8 的整数；n1 和 n2 各自独立地为 0 至 2 的整数；k1 和 k2 各自独立地为 0 至 8 的整数。k1 和 k2 之和不小于 1，a1 和 k1 之和不小于 1。a2 和 k2 之和不大于 8。