cyclohexyldiphenylmethanol | 4404-61-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cyclohexyldiphenylmethanol
• 英文别名: Diphenyl-cyclohexyl-methanol；cyclohexyl(diphenyl)methanol
• CAS: 4404-61-9
• 化学式: C₁₉H₂₂O
• 分子量: 266.383
• InChiKey: LRWTTZKTXXYPNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  cyclohexyldiphenylmethanol 生成 环亚己基二苯基甲烷
  参考文献：
  名称：

  Hell; Schaal, Chemische Berichte, 1907, vol. 40, p. 4166

  摘要：

  DOI：
• 作为产物：
  描述：

  环己甲酰氯 在 吡啶 、 乙醚 、 氯仿 作用下， 生成 cyclohexyldiphenylmethanol
  参考文献：
  名称：

  Mechanism of the Reaction between Hindered Carbonyl Compounds and the Grignard Reagent. II¹

  摘要：

  DOI：

  10.1021/ja01264a043

文献信息

• Hydrocarbon Activation. Synthesis of β-Cycloalkyl (Di)nitriles through Photosensitized Conjugate Radical Addition
  作者：Anna Maria Cardarelli、Maurizio Fagnoni、Mariella Mella、Angelo Albini

  DOI：10.1021/jo010400k

  日期：2001.11.1

  Photoinduced hydrogen abstraction from aliphatic cyclic hydrocarbons (C(5) to C(7), C(12), as well as adamantane) by triplet aromatic ketones in the presence of alpha,beta-unsaturated (di)nitriles offers a straightforward entry to the corresponding alkylated (di)nitriles via the alkyl radicals. Yields are moderate to good depending on the olefins structure (substitution in beta slows down the addition

  在存在α，β-不饱和（di）腈的情况下通过三重芳族酮从脂肪族环状烃（C（5）到C（7），C（12）以及金刚烷）的光诱导氢提取提供了直接的途径经由烷基的相应的烷基化的（二）腈。取决于烯烃的结构，产率中等至良好（β取代会减慢单腈的加成，但对于α，α-二腈，电子活化也可使β，β-二取代底物有效烷基化）。用（1-甲基戊-4-烯叉）丙二腈获得了串联烷基化-环化方法。
• Contrasting chemistry of diphenylcarbene and fluorenylidene in cyclohexane
  作者：T.G. Savino、V.P. Senthilnathan、M.S. Platz

  DOI：10.1016/s0040-4020(01)90595-2

  日期：1986.1

  The chemistry of diphenylcarbene and fluorenylidene in cyclohexane was investigated. An examination of the product distributions, radical scavenging experiments and isotopic fractionation established that diphenylcarbene reacts with cyclohexane predominantly, if not exclusively, through its triplet state whereas fluorenylidene exhibits substantial chemistry from its low lying singlet state in addition

  研究了二苯卡宾和芴基在环己烷中的化学性质。对产物分布，自由基清除实验和同位素分馏的检查确定，二苯卡宾主要（如果不是唯一的话）通过其三重态与环己烷反应，而芴基除其三重态化学外还表现出低位单重态的实质化学性质。结果表明，芴基的单重态-三重态分裂比二苯基碳烯中的单峰-三重态分裂小。化学研究与先前的激光闪光光解实验一致。
• Bis(tri-n-butylstannyl)benzopinacolate: Preparation and use as a mediator of intermolecular free radical reactions
  作者：David J. Hart、Ramanarayanan Krishnamurthy、Lori M. Pook、Franklin L. Seely

  DOI：10.1016/s0040-4039(00)61484-3

  日期：1993.12

  Bis(tri-n-butylstannyl)benzopinacolate (2) serves as a thermal source of tri-n-butylstannyl radicals and mediates intermolecular coupling of selected alkyl halides to O-benzylformaldoxime and electron deficient olefins. A free radical non-chain mechanism is proposed for these reactions.

  双（三正丁基锡烷基）苯甲酸频哪酸酯（2）充当三正丁基锡烷基自由基的热源，并介导所选的烷基卤化物与O-苄基甲醛肟和缺电子烯烃的分子间偶联。提出了用于这些反应的自由基非链机制。
• Highly Efficient Alkylation to Ketones and Aldimines with Grignard Reagents Catalyzed by Zinc(II) Chloride
  作者：Manabu Hatano、Shinji Suzuki、Kazuaki Ishihara

  DOI：10.1021/ja0628405

  日期：2006.8.1

  efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2 (10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products

  在由 ZnCl2 (10 mol%) 衍生的催化三烷基锌 (II) 酸酯配合物的存在下，使用格氏试剂高效地烷基化为酮和醛亚胺。这种简单的 Zn(II) 催化烷基化可以最大限度地减少仅使用格氏试剂而导致还原和羟醛副产物的众所周知但严重的问题，并且可以提高所需烷基化产物的产率。
• Synthesis and Application of 2,6-Bis(trifluoromethyl)-4-pyridyl Phosphanes: The Most Electron-Poor Aryl Phosphanes with Moderate Bulkiness
  作者：Toshinobu Korenaga、Aram Ko、Kotaro Uotani、Yuki Tanaka、Takashi Sakai

  DOI：10.1002/anie.201104588

  日期：2011.11.4

  The poor will be rich: BFPy phosphanes (see scheme) mimic the electronic and steric characters of P(C6F5)3 and PPh3, respectively. These novel ligands showed a large ligand acceleration effect on Stille coupling, the Rh‐catalyzed 1,2‐addition of aryl boronic acid to unactivated ketones and the asymmetric arylation of N‐tosylimine using phenylboronic acid.

  穷人将变得富有：BFPy膦（参见方案）分别模仿P（C 6 F 5）3和PPh 3的电子和位阻特征。这些新颖的配体对Stille偶联，Rh催化的1,2-芳基硼酸加成到未活化的酮上以及N-甲苯磺胺使用苯基硼酸的不对称芳基化表现出很大的配体促进作用。