[Pt(di(2-picolyl)amine)Cl]Cl | 356070-43-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Pt(di(2-picolyl)amine)Cl]Cl
• 英文别名: [PtCl(bis(2-pyridylmethyl)amine)]Cl；dichloroplatinum;1-pyridin-2-yl-N-(pyridin-2-ylmethyl)methanamine
• CAS: 356070-43-4
• 化学式: C₁₂H₁₃ClN₃Pt*Cl
• 分子量: 465.241
• InChiKey: GVUVDIZYIOZASU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pt(di(2-picolyl)amine)Cl]Cl 、 silver trifluoromethanesulfonate 以 水 为溶剂， 反应 0.5h， 以44%的产率得到[Pt(dpa)Cl](CF₃SO₃)
  参考文献：
  名称：

  A Dinuclear Platinum(II) N4Py Complex: An Unexpected Coordination Mode For N4Py

  摘要：

  The polypyridyl compound N,N-bis(2-pyridylinethyl)-N-bis(2-pyridyl)methylamine (N4Py) acts as a bridging ligand and coordinates to two Pt(II) ions giving an unexpected diplatinum(II) complex, whose photophysical and anticancer properties were investigated.

  DOI：

  10.1021/acs.inorgchem.5b01032
• 作为产物：
  描述：

  cis-dichlorobis(dimethylsulfoxide)platinum(II) 、 二甲基吡啶胺 以 二氯甲烷 为溶剂， 反应 24.0h， 以98%的产率得到[Pt(di(2-picolyl)amine)Cl]Cl
  参考文献：
  名称：

  HIV NCp7蛋白与包含三齿配体的铂（II）和金（III）配合物的相互作用

  摘要：

  人类免疫缺陷病毒（HIV）核衣壳蛋白（NCp7）在病毒的生命周期中起着重要作用，并已被可能导致其变性或阻止其与病毒RNA相互作用的化合物作为目标。在本文中，我们描述了铂（II）和金（III）配合物与NCp7的相互作用，以及如何通过明智地选择配体来调节潜在抑制剂的反应性/亲和力。[MCl（N 3）] n +（M = Pt 2+（n = 1）和Au 3+（n = 2）； N 3 =三齿螯合配体：双（2-吡啶基甲基）甲胺（Mebpma，L 1）和双（2-吡啶基甲基）胺（bpma，通过电喷雾电离质谱（ESI-MS）研究了具有NCp7（ZF2）C末端锌指的L 2）。[MCl（Mebpma）] n +配合物（PtL 1和AuL 1）与ZF2的孵育质谱表明，它们比以前研究的含二亚乙基三胺类似物[MCl（dien）] n +更具反应性。PtL 1与ZF2反应的初始产物导致所有配体的损失和锌的释放，从而产生了铂化的凋亡肽{PtF}（F

  DOI：

  10.1021/acs.inorgchem.6b01925

文献信息

• Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction
  作者：Xiao-Hui Zheng、Ge Mu、Yi-Fang Zhong、Tian-Peng Zhang、Qian Cao、Liang-Nian Ji、Yong Zhao、Zong-Wan Mao

  DOI：10.1039/c6cc08254h

  日期：——

  Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomeric DNA damage and telomere end-loss.

  三叉神经状铂配合物通过四链体介导的端粒DNA损伤和端粒丢失诱导癌细胞衰老。
• Two novel fan-shaped trinuclear Pt(<scp>ii</scp>) complexes act as G-quadruplex binders and telomerase inhibitors
  作者：Cui-Xia Xu、Liu-Yi Liu、Bei Lv、Hao-Yu Zhao、Qian Cao、Teng Zhai、Zong-Wan Mao

  DOI：10.1039/d0dt01767a

  日期：——

  Two new trinuclear Pt(II) complexes [Pt(dien)]3(tib)}(NO3)6 (1) and [Pt(dpa)]3(tib)}(NO3)6 (2) (dien: diethylenetriamine, dpa: bis-(2-pyridylmethyl)amine, tib: 1,3,5-tris(1H-imidazol-1-yl)benzene) have been designed, synthesized, characterized and applied to a series of biochemical studies. We found that both of the Pt(II) complexes exhibited much better selectivity for human telomeric G-quadruplex

  两个新的三核Pt（II）络合物[Pt（dien）] 3（tib）}（NO 3）6（1）和[Pt（dpa）] 3（tib）}（NO 3）6（2）（二烯：二亚乙基三胺，dpa：双-（2-吡啶基甲基）胺，tib：1,3,5-三（1 H-咪唑-1-基）苯）已被设计，合成，表征并应用于一系列生化研究学习。我们发现两个Pt（II）复合物对人端粒G-四链体序列的选择性比启动子G-四链体（c-kit，c-myc和bcl2）或双链体DNA更好。通过表面等离振子共振，荧光共振能量转移和聚合酶链反应终止试验的研究，两种复合物均显示出相对的稳定性和对人端粒G-四链体的亲和力。圆二色性表明两种复合物都可以诱导并稳定反平行的G-四链体结构。分子对接表明Pt（II）配合物插入人端粒G四联体的大凹槽中（PDB ID：143D）。此外，端粒重复扩增方案分析定量评估了由Pt（II）引起的端粒酶活性的抑制。）复合体。对于1和2，获得的IC
• A Platinum(II)‐based Photosensitive Tripod as an Effective Photodynamic Anticancer Agent through DNA Damage
  作者：Yi‐Fang Zhong、Hang Zhang、Wen‐Ting Liu、Xiao‐Hui Zheng、Yi‐Wei Zhou、Qian Cao、Yong Shen、Yong Zhao、Peter Z. Qin、Liang‐Nian Ji、Zong‐Wan Mao

  DOI：10.1002/chem.201703598

  日期：2017.11.21

  Herein, two photosensitive platinum(II)‐based tripods were designed and synthesized. Notably, complex 1 ([Pt(dien)]3L}(NO3)6, L=tri(4‐pyridylphenyl)amine and dien=diethylenetriamine), which mainly accumulated in the cell nucleus, exhibited very low cytotoxicity in the absence of light irradiation, but displayed a remarkable increase in cytotoxicity upon visible light irradiation. Mechanistic investigations

  本文设计并合成了两个基于光敏铂（II）的三脚架。值得注意的是，主要在细胞核中积累的复合物 1（[Pt（dien）] 3 L }（NO 3）6，L =三（4-吡啶基苯基）胺和二烯=二亚乙基三胺），在细胞核中表现出非常低的细胞毒性。没有光照射，但是在可见光照射下显示出明显的细胞毒性增加。机理研究表明，该三脚架与细胞核中的DNA相互作用，在光照射下诱导ROS生成，因此引起快速的DNA损伤反应。从而触发癌细胞凋亡。
• Stabilization of Human Telomeric G-Quadruplex and Inhibition of Telomerase Activity by Propeller-Shaped Trinuclear Pt^IIComplexes
  作者：Cui-Xia Xu、Yong Shen、Qian Hu、Yu-Xuan Zheng、Qian Cao、Peter Z. Qin、Yong Zhao、Liang-Nian Ji、Zong-Wan Mao

  DOI：10.1002/asia.201402258

  日期：2014.9

  propeller‐shaped, trigeminal‐ligand‐containing, flexible trinuclear PtII complexes, [Pt(dien)]3(ptp)}(NO3)6 (1) and [Pt(dpa)]3(ptp)}(NO3)6 (2) (dien: diethylenetriamine; dpa: bis‐(2‐pyridylmethyl)amine; ptp: 6′‐(pyridin‐3‐yl)‐3,2′:4′,3′′‐terpyridine), have been designed and synthesized, and their interactions with G‐quadruplex (G4) sequences are characterized. A combination of biophysical and biochemical

  两种新型的螺旋桨形，含三叉基配体的柔性三核Pt II复合物，[Pt（dien）] 3（ptp）}（NO 3）6（1）和[Pt（dpa）] 3（ptp） }（NO 3）6（2）（dien：二亚乙基三胺； dpa：双-（2-吡啶基甲基）胺； ptp：6′-（吡啶-3-基）-3,2′：4′，3′′-特吡啶），已经设计和合成，并表征了它们与G-四链体（G4）序列的相互作用。生物物理和生化分析的组合显示，Pt II复合物对人端粒（hTel）和c-myc启动子G4序列均显示出比双链DNA高的亲和力。综合大楼1结合和稳定hTel G4序列比复杂2更有效。发现两种复合物均可诱导和稳定G4结构的反平行或平行构象。分子对接研究表明，复合物1结合到反平行hTel G4结构的大凹槽中（PDB ID：143D），而复合物2堆叠到平行hTel G4结构的裸露G四重物上（PDB ID：1KF1）。端粒重复扩增方案分
• Guanine Nucleobase Adducts Formed by [Pt(di-(2-picolyl)amine)Cl]Cl: Evidence That a Tridentate Ligand with Only in-Plane Bulk Can Slow Guanine Base Rotation
  作者：Chase Andrepont、Patricia A. Marzilli、Luigi G. Marzilli

  DOI：10.1021/ic3018634

  日期：2012.11.5

  Pt(II) complexes bind preferentially at N7 of G residues of DNA, causing DNA structural distortions associated with anticancer activity. Some distortions induced by difunctional cisplatin are also found for monofunctional Pt(II) complexes with carrier ligands having bulk projecting toward the guanine base. This ligand bulk can be correlated with impeded rotation about the Pt-N7(guanine) bond. Pt(N(H)-dpa)(G) adducts (N(H)dpa = di-(2-picolyl)amine, G = 5'-GMP, 5'-GDP, 5'-GTP, guanosine, 9-EtG, and 5'-IMP) were used to assess whether a tridentate carrier ligand having bulk concentrated in the coordination plane can impede guanine nucleobase rotation. Because the Pt(N(H)dpa) moiety contains a mirror plane but is unsymmetrical with respect to the coordination plane, Pt(N(H)dpa)(G) adducts can form anti or syn rotamers with the guanine O6 and the central N-H of N(H)dpa on the opposite or the same side of the coordination plane, respectively. The observation of two sharp, comparably intense guanine H8 NMR signals provided evidence that these Pt(N(H)dpa)(G) adducts exist as mixtures of syn and anti rotamers, that rotational interchange is impeded by N(H)dpa, and that the key interactions involves steric repulsions between the pyridyl and guanine rings. The relative proximity of the guanine H8 to the anisotropic pyridyl rings allowed us to conclude that the syn rotamer was usually more abundant. However, the anti rotamer was more abundant for the Pt(N(H)dpa)(5'-GTP) adduct, in which a hydrogen bond between the 5'-GTP gamma-phosphate group and the N(H)dpa central N-H is geometrically possible. In all previous examples of the influence of hydrogen bond formation on rotamer abundance in Pt(II) guanine adducts, these hydrogen bonding interactions occurred between ligand groups in cis positions. Thus, the role of a trans ligand group in influencing rotamer abundance, as found here, is unusual.