o-cyanophenyllithium | 59043-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-cyanophenyllithium
• 英文别名: o-lithiobenzonitrile；2-cyano-phenyllithium
• CAS: 59043-57-1
• 化学式: C₇H₄LiN
• 分子量: 109.056
• InChiKey: FNULIXBVQYLPIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.98
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  o-cyanophenyllithium 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.83h， 生成 2,3-Diphenyl-phthalimidin
  参考文献：
  名称：

  Schiff bases as external and internal electrophiles in reactions of functionalized organolithium reagents. A new route to isoindoline derivatives and 1,2,3,4-tetrahydroisoquinolines

  摘要：

  DOI：

  10.1021/jo00315a021
• 作为产物：
  描述：

  2-溴苯腈 、 正丁基锂 生成 o-cyanophenyllithium
  参考文献：
  名称：

  PARHAM W. E.; PICCIRILLI R. M., J. ORG. CHEM. , 1976, 41, NO 7, 1268-1269

  摘要：

  DOI：

文献信息

• Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles
  作者：Aiichiro Nagaki、Daisuke Ichinari、Jun-ichi Yoshida

  DOI：10.1021/ja5071762

  日期：2014.9.3

  carbolithiation of benzyne with the aryllithium took place spontaneously. The resulting functionalized biaryllithium was reacted with an electrophile in the subsequent reactor to give the corresponding three-component coupling product. The precise optimization of reaction conditions using the temperature-residence time mapping is responsible for the success of the present transformation. The present method

  建立了一种基于闪速化学的苯三组分偶联流动微反应器方法。由 1-溴-2-碘苯产生的邻溴苯基锂和由相应芳基卤化物产生的官能化芳基锂在 -70 °C 下混合。在随后的反应器中，邻溴苯基锂在 -30°C 下分解生成苄基而不影响官能化的芳基锂，并且苄基与芳基锂的碳锂化反应自发发生。所得官能化联芳基锂在随后的反应器中与亲电试剂反应，得到相应的三组分偶联产物。使用温度-停留时间映射对反应条件进行精确优化是目前转化成功的原因。
• 2-Phenyl indene derivatives useful as estrogen receptor ligands
  申请人：Jernstedt Henrik

  公开号：US20090326018A1

  公开（公告）日：2009-12-31

  The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are as defined in the specification, and wherein either the bond between the C1 and C2 carbon atoms is a double bond or the bond between the C2 and C3 carbon atoms is a double bond, R 2 being absent when the bond between the C1 and C2 carbon atoms is a double bond.

  本发明提供了化合物(I)或其药学上可接受的酯、酰胺、溶剂合物或盐，包括这种酯或酰胺的盐，以及这种酯、酰胺或盐的溶剂合物。本发明还提供了在与雌激素受体活性相关的疾病或紊乱的情况下使用这些化合物进行治疗或预防的方法。其中，化合物(I)的R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11和R12如规范中所定义，在C1和C2碳原子之间的键是双键或C2和C3碳原子之间的键是双键时，R2不存在。
• Versatile and Functionalised Intermediates for the Synthesis of Vitamin D and Novel Vitamin D Derivatives
  申请人：ENDOTHERM GMBH

  公开号：US20150344421A1

  公开（公告）日：2015-12-03

  Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

  提供了用于完全合成维生素D的新型中间体，这些中间体允许在最终维生素衍生物中具有极大的功能性基团多样性。提供了在3号位置外消旋的维生素衍生物和在18号位置具有广泛功能性的维生素衍生物，包括具有同位素标记的化合物。
• VERSATILE AND FUNCTIONALISED INTERMEDIATES FOR THE SYNTHESIS OF VITAMIN D AND NOVEL VITAMIN D DERIVATIVES
  申请人：Endotherm GmbH

  公开号：EP2933246B1

  公开（公告）日：2020-01-08
• WO2008/43567
  申请人：——

  公开号：——

  公开（公告）日：——