(5S)-5-hydroxy-N-methyldecanamide | 1095329-28-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S)-5-hydroxy-N-methyldecanamide
• CAS: 1095329-28-4
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.309
• InChiKey: GPPKDKSQYUVWOS-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-methyl-5-hydroxydecanamide 在 Novozym 435 、 苯甲酸乙烯酯 作用下， 以 乙醚 为溶剂， 反应 168.0h， 生成 (5R)-5-hydroxy-N-methyldecanamide 、 (5S)-5-hydroxy-N-methyldecanamide
  参考文献：
  名称：

  Enantioselective Synthesis of δ-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction

  摘要：

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.

  DOI：

  10.1080/00397911.2010.529230

文献信息

• Enantioselective Synthesis of <font>δ</font>-Lactones with Lipase-Catalyzed Resolution and Mitsunobu Reaction
  作者：Yasutaka Shimotori、Masakazu Aoyama、Tetsuo Miyakoshi

  DOI：10.1080/00397911.2010.529230

  日期：2012.3.1

  Both enantiomers of a series of delta-lactones (e.g., delta-decalactone, delta-dodelactone, and delta-hexadecalactone) were synthesized stereoselectively by Novozym 435-catalyzed resolution. Furthermore, only (S)-enantiomers of delta-lactones were synthesized with a combination of Novozym 435-catalyzed resolution and Mitsunobu reaction.