acetic acid octanoic acid-anhydride | 18698-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid octanoic acid-anhydride
• 英文别名: Essigsaeure-octansaeure-anhydrid；Caprylsaeure-essigsaeure-anhydrid；Acetyl Octanoate
• CAS: 18698-50-5
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: ADCQBLMDYBHFGK-UHFFFAOYSA-N

物化性质

• 沸点：
  227.8±8.0 °C(Predicted)
• 密度：
  0.959±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙烯酮 、 辛酸 在 乙醚 作用下， 生成 acetic acid octanoic acid-anhydride
  参考文献：
  名称：

  Acetylation of Monocarboxylic Acids with Ketene

  摘要：

  DOI：

  10.1021/ja01620a060

文献信息

• [EN] N-OXIDES OF 4,5-EPOXY-MORPHINANIUM ANALOGS<br/>[FR] N-OXYDES D'ANALOGUES 4,5-ÉPOXY-MORPHINANIUM
  申请人：PROGENICS PHARM INC

  公开号：WO2009067275A1

  公开（公告）日：2009-05-28

  Novel N-oxides of 4,5-epoxy-morphinanIum analogs are disclosed. Pharmaceutical compositions containing the N-oxides of 4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.

  揭示了4,5-环氧吗啡啉盐类的新型N-氧化物。还揭示了含有4,5-环氧吗啡啉盐类的N-氧化物的药物组合物，以及它们的药用方法。所揭示的化合物可用作阿片受体调节剂等用途。
• ISOMETHEPTENE ISOMER
  申请人：TONIX PHARMACEUTICALS INC.

  公开号：US20140212486A1

  公开（公告）日：2014-07-31

  The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH). The (R)-Isometheptene enantiomer or isomer 2 is believed to effectively lower blood pressure, used alone or together with other headache ameliorating drugs. Methods of synthesis and treatment are described. Regarding (R)-Isometheptene crystals data of X-ray crystallography are presented.

  该发明涉及一种纯化的异甲苯丙胺化合物，其结构符合式(I)，或其盐酸盐，或其药用上可接受的加合物。具体而言，该公开涉及异甲苯丙胺异构体粘酸晶体2的合成、纯化和表征，其中异甲苯丙胺异构体2的立体化学特性为(R)-对映体。异甲苯丙胺(R)-对映体活性表明其为咪唑啉亚型1(I1)受体位点的选择性中枢作用选择性配体；更具体地，该公开提供了一种用于治疗偏头痛和其他源自腹部不适的神经血管性或神经源性疼痛的降压组合物。异甲苯丙胺(R)-对映体或异构体2可能是一种抗高血压药物，其副作用较盐酸异甲苯丙胺的形式更少。因此，人们认为异甲苯丙胺(R)对映体对阵发性张力型头痛(ETTH)有效。异甲苯丙胺(R)对映体或异构体2被认为能有效降低血压，可单独使用或与其他缓解头痛药物一起使用。描述了合成和治疗方法。关于异甲苯丙胺(R)晶体的X射线衍射数据已被提供。
• (S)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
  申请人：Perez Julio

  公开号：US20080207669A1

  公开（公告）日：2008-08-28

  Novel (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, hypermotility of the gastrointestinal tract.

  本专利揭示了7,8-饱和-4,5-环氧-吗啡盐类的（S）-N-立体异构体。还揭示了含有7,8-饱和-4,5-环氧-吗啡盐类（S）-N-立体异构体的药物组合物，以及其药用方法。这些类似物被发现可用于治疗多种情况，包括胃肠道过度运动。
• [EN] RIGID DERIVATIVES OF TRIPTOLIDE AS ANTICANCER, IMMUNE SUPPRESSANT, ANTI-FIBROSIS, AND CNS PROTECTANT AGENTS<br/>[FR] DÉRIVÉS RIGIDES DE TRIPTOLIDE EN TANT QU'AGENTS ANTICANCÉREUX, IMMUNOSUPPRESSEURS, ANTIFIBROTIQUES, ET PROTECTEURS DU SYSTÈME NERVEUX CENTRAL (CNS)
  申请人：MYELORX LLC

  公开号：WO2009023201A1

  公开（公告）日：2009-02-19

  Compounds having the Formula I: are useful for inducing cell death (apoptosis), in immune suppression, in treating fibrosis and protecting CNS cell death. In Formulate I, R1 is OX and R2 - R7 is H or OX. X is COY, COOY, or CONHY.

  具有I式的化合物对于诱导细胞死亡（凋亡），免疫抑制，治疗纤维化和保护中枢神经系统细胞死亡非常有用。在I式中，R1为OX，R2 - R7为H或OX。X为COY，COOY或CONHY。
• Complexes made using low solubility drugs
  申请人：Wong S.L. Patrick

  公开号：US20060134204A1

  公开（公告）日：2006-06-22

  Disclosed herein are substances that include a complex that includes a drug moiety ionically bound to a counter-ion; wherein a solubility of the complex is greater than a solubility of the drug moiety. Also disclosed are compositions and dosage forms made from such substances and complexes; methods of making compositions, substances, and complexes; and methods of administering the same to patients.

  本文揭示了一种物质，其中包括一种复合物，该复合物包括离子键合的药物基团和对离子；其中复合物的溶解度大于药物基团的溶解度。还揭示了由这种物质和复合物制成的组合物和剂型；制备组合物、物质和复合物的方法；以及将其用于患者的方法。