β-phenyl-β-propiolactone | 4287-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: β-phenyl-β-propiolactone
• 英文别名: 3-Phenyl-propiolacton；4-phenyl-oxetan-2-one；4-Phenyloxetan-2-one
• CAS: 4287-98-3
• 化学式: C₉H₈O₂
• 分子量: 148.161
• InChiKey: GVFHVYLTQWYDPA-UHFFFAOYSA-N

物化性质

• 沸点：
  278.6±29.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  β-phenyl-β-propiolactone 在 镍 作用下， 180.0 ℃ 、4.9 MPa 条件下， 生成 3-环己基丙酸
  参考文献：
  名称：

  Preparation of substituted lower aliphatic acids

  摘要：

  公开号：

  US02484497A1
• 作为产物：
  描述：

  乙烯酮 、 苯甲醛 在 (R,R)-1,2-bis-(3,5-bis(trifluoromethyl)phenylsulfonylamino)-1,2-diphenylethane-Et₃Al 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 β-phenyl-β-propiolactone
  参考文献：
  名称：

  Asymmetric [2 + 2] cycloaddition of ketene with aldehydes catalysed by chiral bissulfonamide–trialkylaluminium complexes

  摘要：

  C2对称性双磺酰胺2a-c-R3Al络合物催化剂用量为10 mol%时，实现了与醛1a-g的不对称[2+2]环加成反应，合成了光学活性的4-取代氧杂环丁烷-2-酮3a-g，其对映体过量率高达74%。

  DOI：

  10.1039/c39940002281

文献信息

• Cationic palladium(ii) complex-catalyzed [2 + 2] cycloaddition and tandem cycloaddition–allylic rearrangement of ketene with aldehydes: an improved synthesis of sorbic acid
  作者：Tetsutaro Hattori、Yutaka Suzuki、Osamu Uesugi、Shuichi Oi、Sotaro Miyano

  DOI：10.1039/a908709e

  日期：——

  Cationic palladium(II) complexes [PdL2(PhCN)2](BF4)2 efficiently catalyze the [2 + 2] cycloaddition of ketene with aldehydes to give the corresponding oxetan-2-ones, among which 4-vinyl-substituted ones are further isomerized under the conditions to give 3,6-dihydro-2H-pyran-2-ones in good yields.

  阳离子钯(II)配合物[PdL2(PhCN)2](BF4)2有效催化烯酮与醛的[2 + 2]环加成反应生成相应的oxetan-2-ones，其中4-乙烯基取代的更进一步条件下异构化，以良好的收率得到 3,6-二氢-2H-吡喃-2-酮。
• PROCESSES FOR PRODUCING BETA-LACTONE AND BETA-LACTONE DERIVATIVES WITH HETEROGENOUS CATALYSTS
  申请人：Novomer, Inc.

  公开号：US20190047972A1

  公开（公告）日：2019-02-14

  The present invention is directed to processes from producing beta-lactone and beta-lactone derivatives using heterogenous catalysts. In preferred embodiments of the present invention, the processes comprise the steps: passing a feed stream comprising an epoxide reagent and a carbon monoxide reagent to a reaction zone; contacting the epoxide reagent and the carbon monoxide reagent with a heterogenous catalyst to produce a beta-lactone product in the reaction zone; and removing the beta-lactone product from the reaction zone. In preferred embodiments, the heterogenous catalyst comprises a solid support containing a cationic Lewis acid functional group and a metal carbonyl compound comprising at least one of anionic metal carbonyl compound or a neutral metal carbonyl compound. In certain preferred embodiments, the epoxide reagent and carbon monoxide reagent have a biobased content.

  本发明涉及使用异质催化剂生产β-内酯和β-内酯衍生物的过程。在本发明的首选实施例中，该过程包括以下步骤：将包含环氧试剂和一氧化碳试剂的进料流通入反应区；将环氧试剂和一氧化碳试剂与异质催化剂接触，在反应区内产生β-内酯产物；并从反应区中移除β-内酯产物。在首选实施例中，异质催化剂包括固体支撑体，其中包含阳离子路易斯酸功能团和金属羰基化合物，其中至少包括一种阴离子金属羰基化合物或中性金属羰基化合物。在某些首选实施例中，环氧试剂和一氧化碳试剂具有生物基含量。
• Method for Producing Polyhydroxyalkanoates
  申请人：Preishuber-Pflugl Peter

  公开号：US20090124787A1

  公开（公告）日：2009-05-14

  The invention relates to a process for preparing polyhydroxyalkanoates by polymerization of lactones of the general formula I, where the substituents and the index n have the meanings given in the description, in the presence of at least one catalyst of the formula (II) L I M a X a m , where the substituents and indices have the meanings given in the description. The invention further relates to poly-3-hydroxybutyrates which have a novel property profile and are obtainable for the first time by means of this process, and also biodegradable polyester mixtures based on these poly-3-hydroxybutyrates.

  本发明涉及一种通过在至少一种催化剂的存在下，聚合通式I的内酯制备聚羟基烷酸酯的方法，其中通式I的取代基和指数n的含义在说明中给出，催化剂的通式为(II) LIMaXam，其中取代基和指数的含义在说明中给出。本发明还涉及具有新的性质特征的聚-3-羟基丁酸酯，首次通过该方法获得，并且基于这些聚-3-羟基丁酸酯的可生物降解聚酯混合物。
• THE REACTION OF SMALL RING COMPOUND WITH CARBON MONOXIDE THE CARBONYLATION OF OXIRANE
  作者：Yoshio Kamiya、Katsuhito Kawato、Hiroyuki Ohta

  DOI：10.1246/cl.1980.1549

  日期：1980.12.5

  The carbonylation of oxiranes catalyzed by rhodium complex afforded β-lactones. Various factors which control the above reaction are presented.

  由铑配合物催化的环氧乙烷羰基化得到β-内酯。介绍了控制上述反应的各种因素。
• Processes for producing beta-lactone and beta-lactone derivatives with heterogenous catalysts
  申请人：Novomer, Inc.

  公开号：US10961209B2

  公开（公告）日：2021-03-30

  The present invention is directed to processes from producing beta-lactone and beta-lactone derivatives using heterogenous catalysts. In preferred embodiments of the present invention, the processes comprise the steps: passing a feed stream comprising an epoxide reagent and a carbon monoxide reagent to a reaction zone; contacting the epoxide reagent and the carbon monoxide reagent with a heterogenous catalyst to produce a beta-lactone product in the reaction zone; and removing the beta-lactone product from the reaction zone. In preferred embodiments, the heterogenous catalyst comprises a solid support containing a cationic Lewis acid functional group and a metal carbonyl compound comprising at least one of anionic metal carbonyl compound or a neutral metal carbonyl compound. In certain preferred embodiments, the epoxide reagent and carbon monoxide reagent have a biobased content.

  本发明涉及使用异质催化剂生产β-内酯和β-内酯衍生物的工艺。在本发明的优选实施方案中，该工艺包括以下步骤：将包含环氧化物试剂和一氧化碳试剂的进料流通入反应区；使环氧化物试剂和一氧化碳试剂与异质催化剂接触，在反应区生成β-内酯产物；从反应区除去β-内酯产物。在优选的实施方案中，异质催化剂包括含有阳离子路易斯酸官能团和金属羰基化合物的固体载体，金属羰基化合物包括阴离子金属羰基化合物或中性金属羰基化合物中的至少一种。在某些优选的实施方案中，环氧化物试剂和一氧化碳试剂具有生物基含量。