N-cyclohexyloxycarbonyl-glycine | 4078-59-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cyclohexyloxycarbonyl-glycine
• 英文别名: N-Cyclohexyloxycarbonyl-glycin；{[(cyclohexyloxy)carbonyl]amino}acetic acid；2-(cyclohexyloxycarbonylamino)acetic acid
• CAS: 4078-59-5
• 化学式: C₉H₁₅NO₄
• 分子量: 201.222
• InChiKey: YANYHCUGPZMRAC-UHFFFAOYSA-N

物化性质

• 熔点：
  99 °C
• 沸点：
  384.2±21.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-cyclohexyloxycarbonyl-glycine 生成 CCO-Gly-amid
  参考文献：
  名称：

  Influence of the nature of the amide group on the rate of splitting out of the carbocyclohexyloxy protector during hydrobrominolysis

  摘要：

  DOI：

  10.1007/bf00850363
• 作为产物：
  描述：

  N-Cyclohexyloxycarbonyl-glycin-ethylester 在 sodium hydroxide 作用下， 生成 N-cyclohexyloxycarbonyl-glycine
  参考文献：
  名称：

  Blaha,K.; Rudinger,J., Collection of Czechoslovak Chemical Communications, 1965, vol. 30, p. 599 - 604

  摘要：

  DOI：

文献信息

• Novel diarylalkene derivatives and novel diarylalkane derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20040167118A1

  公开（公告）日：2004-08-26

  The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: 1 wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

  该发明涉及以下一般式（1）或其类似物所代表的化合物，该化合物选择性地抑制N型钙通道或其类似物，并涉及将该一般式（1）或其类似物所代表的化合物用于需要此类治疗的患者的治疗方法： 1 其中，A代表CH═CH等，a、b、c和d代表CH等，R1、R2、R3、R4、R5和R6代表H等，V—W代表C═C等，n代表0至3，Y1代表O等，B代表—(CH2)vCHR21，其中v为0至3，R21代表H、较低的烷基基团或类似物等，G代表—CO—、共价键等，m为0至6，R7和R8代表H、较低的烷基基团、—COR18a、—COOR20，其中R18a和R20各自代表较低的烷基基团或类似物等。
• Compounds and Compositions as Channel Activating Protease Inhibitors
  申请人：Tully C. David

  公开号：US20070275906A1

  公开（公告）日：2007-11-29

  The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

  该发明提供了化合物及其制药组合物，用于调节通道激活蛋白酶，并使用这些化合物来治疗、改善或预防与通道激活蛋白酶相关的疾病的方法，包括但不限于前列腺蛋白酶、PRSS22、TMPRSS11（例如TMPRSS11B、TMPRSS11E）、TMPRSS2、TMPRSS3、TMPRSS4（MTSP-2）、麦曲蛋白酶（MTSP-1）、CAP2、CAP3、胰蛋白酶、卡特普辛A或中性粒细胞弹性蛋白酶。
• Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
  申请人：Iwayama Satoshi

  公开号：US20050009814A1

  公开（公告）日：2005-01-13

  The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

  本发明涉及一种用于预防/治疗疼痛的药物组合物，包括加巴喷丁或普瑞巴林或其药学上可接受的盐和N型钙通道拮抗剂或其药学上可接受的盐，例如具有以下结构的化合物。
• NOVEL DIARYLALKENE DERIVATIVES AND NOVEL DIARYLALKANE DERIVATIVES
  申请人：YAMAMOTO Takashi

  公开号：US20080058311A1

  公开（公告）日：2008-03-06

  The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

  本发明涉及一种由以下通式（1）或其类似物表示的化合物，其选择性地抑制N型钙通道或其类似物，并提供一种治疗疼痛等方法，包括将由以下通式（1）或其类似物表示的化合物应用于需要此类治疗的患者中：其中，A表示CH═CH等，a、b、c和d表示CH等，R1、R2、R3、R4、R5和R6表示H等，V—W表示C═C等，n表示0至3，Y1表示O等，B表示—（CH2）vCHR21，其中v为0至3，R21表示H、较低的烷基或类似物等，G表示—CO—、共价键等，m为0至6，R7和R8表示H、较低的烷基、—COR18a、—COOR20，其中R18a和R20各自表示较低的烷基或类似物等。
• Diarylalkene derivatives and novel diarylalkane derivatives
  申请人：Ajinomoto Co., Inc.

  公开号：US08278329B2

  公开（公告）日：2012-10-02

  The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

  本发明涉及一种由以下通式（1）或其类似物表示的化合物，其有选择性地抑制N型钙通道或其类似物，并提供了一种治疗疼痛等疾病的方法，包括将由以下通式（1）或其类似物表示的化合物用于需要此类治疗的患者中：其中，A表示CH═CH等，a、b、c和d表示CH等，R1、R2、R3、R4、R5和R6表示H等，V—W表示C═C等，n表示0至3，Y1表示O等，B表示—（CH2）vCHR21，其中v为0至3，R21表示H、低级烷基或类似物等，G表示—CO—、共价键等，m为0至6，R7和R8表示H、低级烷基、—COR18a、—COOR20，其中R18a和R20各表示低级烷基或类似物等。