4,4'-(2-amino-ethylidene)-di-phenol; hydrochloride | 3516-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-(2-amino-ethylidene)-di-phenol; hydrochloride
• 英文别名: 4,4'-(2-Amino-aethyliden)-di-phenol; Hydrochlorid；4,4'-(2-Aminoethylidene)bisphenol hydrochloride；2,2-Bis(4-hydroxyphenyl)ethylamine hydrochloride；4-[2-amino-1-(4-hydroxyphenyl)ethyl]phenol;hydrochloride
• CAS: 3516-08-3
• 化学式: C₁₄H₁₅NO₂*ClH
• 分子量: 265.74
• InChiKey: SNPUZBJQFJMXSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66.5
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,4'-(2-amino-ethylidene)-di-phenol; hydrochloride 在 碳酸氢钠 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 生成 N-[2,2-Bis-(3-azepan-1-ylmethyl-4-hydroxyphenyl)ethyl]-2,2-diphenylacetamide
  参考文献：
  名称：

  Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

  摘要：

  Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00404-7
• 作为产物：
  描述：

  章胺盐酸盐 、 苯酚 在 盐酸 作用下， 以 甲醚 为溶剂， 以68%的产率得到4,4'-(2-amino-ethylidene)-di-phenol; hydrochloride
  参考文献：
  名称：

  Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

  摘要：

  Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00404-7

文献信息

• US6124280A
  申请人：——

  公开号：US6124280A

  公开（公告）日：2000-09-26
• Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers
  作者：Robert M. Schelkun、Po-wai Yuen、Thomas C. Malone、David M. Rock、Sally Stoehr、Balazs Szoke、Katalin Tarczy-Hornoch

  DOI：10.1016/s0960-894x(99)00404-7

  日期：1999.8

  Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.