2-dimethylaminothiophenol | 18087-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 2-dimethylaminothiophenol
• 英文别名: 2-Dimethylaminobenzenethiol；o-Dimethylaminothiophenol；2-(Dimethylamino)benzenethiol
• CAS: 18087-24-6
• 化学式: C₈H₁₁NS
• mdl: MFCD11111077
• 分子量: 153.248
• InChiKey: GUIVWDGHJPXFJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-dimethylaminothiophenol 在 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 乙醇 、 氯仿 为溶剂， 反应 1.5h， 生成 2-(1H-Benzimidazol-2-yl sulphinyl)-N,N-dimethyl benzenamine
  参考文献：
  名称：

  Amino acid amides of 2-[(2-aminobenzyl)sulfinyl]benzimidazole as acid-stable prodrugs of potential inhibitors of H+K+ ATPase

  摘要：

  A series of amino acid amides of 2-[(2-aminobenzyl)sulfinyl]benzimidazole were prepared and found to possess gastric antisecretory activity on oral administration. (Glycylaminobenzyl)sulfinyl compound 23a, stable in artificial gastric juice (pH 1.2), was given orally to dogs. It was absorbed efficiently and converted into aniline derivative 7a which showed a very high plasma concentration. Compound 23a was hydrolyzed by the action of aminopeptidase present in plasma or the brush border fraction of the small intestine to release the terminal glycine. omicron-Aniline derivatives showed good activity in in vitro H+/K+-ATPase inhibition as well as in the inhibition of histamine stimulated acid secretion in isolated bullfrog gastric mucosa. Although these omicron-aniline derivatives showed no or weak gastric antisecretory activity in rat by id administration, they were active when administered ip. Therefore, these amino acid amides were considered to be acid stable prodrugs of proton pump inhibiting omicron-aniline derivatives. The mechanism of H+/K+-ATPase inhibition of 7a was also examined.

  DOI：

  10.1016/0223-5234(91)90024-h

文献信息

• [EN] HETEROCYCLYL POLYMETHINE IR CHROMOPHORES<br/>[FR] CHROMOPHORES IR À BASE DE POLYMÉTHINE HÉTÉROCYCLYLE
  申请人：UNIV CALIFORNIA

  公开号：WO2020118116A1

  公开（公告）日：2020-06-11

  The present disclosure provides NIR- and SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, and photodynamic therapy.

  本公开提供了具有改进性能的近红外和短波红外活性小分子聚甲啉染料，用于光学成像、光热疗法和光动力疗法。
• [EN] SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS<br/>[FR] SYNTHÈSE DE DELTA 12-PGJ3 ET COMPOSÉS ASSOCIÉS
  申请人：UNIV RICE WILLIAM M

  公开号：WO2015048268A1

  公开（公告）日：2015-04-02

  In one aspect, the present invention provides novel derivatives of Δ12-PGJ3 and modular synthetic pathways to obtaining Δ12-PGJ3 and derivatives thereof. In some aspects, the present derivatives of Δ12-PGJ3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

  在一个方面，本发明提供了Δ12-PGJ3的新颖衍生物以及获取Δ12-PGJ3及其衍生物的模块化合成途径。在某些方面，目前的Δ12-PGJ3衍生物可用作化疗药物。本公开还描述了这些衍生物的组合物以及这些衍生物的使用方法。
• Anti-protozoal oxadiazole derivatives
  申请人：Burroughs Wellcome Co.

  公开号：US04294843A1

  公开（公告）日：1981-10-13

  Anti-protozoal 1,2,4-oxadiazole derivatives of the formula: ##STR1## wherein R.sup.1 is amino or substituted amino; each R.sup.2 is the same or different in one or more of the 3, 4, 5 or 6 positions and is hydrogen, lower alkyl, halogen, hydroxy, alkoxy, alkylthio, arylthio, amino, substituted amino, cyano or nitro; X and Y together represent a bond or X and Y are both hydrogen; R.sup.3 is hydrogen, lower alkyl, aryl, substituted aryl or ArS.CH.sub.2 --; and Ar is unsubstituted or mono-, di- or tri-substituted phenyl wherein the substituents may be the same of different, and acid addition salts thereof, methods for their preparation, formulations thereof and their use in the treatment of protozoal infections, especially malaria are described.

  公式为：##STR1##其中R.sup.1是氨基或取代氨基；每个R.sup.2在3、4、5或6位置中一个或多个位置上相同或不同，且为氢、较低烷基、卤素、羟基、烷氧基、烷基硫、芳基硫、氨基、取代氨基、氰基或硝基；X和Y一起表示键合或X和Y都是氢；R.sup.3是氢、较低烷基、芳基、取代芳基或ArS.CH.sub.2 --；Ar是未取代或单、双或三取代苯基，其中取代基可能相同或不同，以及其酸盐补充物，描述了其制备方法、配方以及在治疗原虫感染，特别是疟疾中的应用。
• [EN] NTCP INHIBITORS<br/>[FR] INHIBITEURS DE NTCP
  申请人：NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

  公开号：WO2019196953A1

  公开（公告）日：2019-10-17

  Provided are cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection (s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

  提供的环孢霉素A类似物是NTCP抑制剂，可用于治疗HBV和/或HDV感染，肝脏保护和改善高胆固醇血症、糖尿病以及抑制癌症。
• BENZOBIS (THIADIAZOLE) DERIVATIVE, INK COMPRISING SAME, AND ORGANIC ELECTRONIC DEVICE COMPRISING SAME
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20160276598A1

  公开（公告）日：2016-09-22

  A benzobis(thiadiazole) derivative represented by the following general formula (1): in which R 1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2): in which R represents a linear or branched alkyl group; R 2 represents a hydrogen atom; and R 3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2); with the proviso that at least one of R 1 and R 3 represents any one of the groups of the formula (2); and two R 1 groups, two R 2 groups, and two R 3 groups may be the same as, or different from each other.

  以下是通式（1）所代表的苯并噻二唑衍生物： 其中，R1代表线性或支链烷基，或以下式子（2）中的任意一种基团： 其中，R代表线性或支链烷基；R2代表氢原子；R3代表氢原子、线性或支链烷基，或以下式子（2）中的任意一种基团； 但是，至少有一个R1和R3代表以下式子（2）中的任意一种基团； 而且，两个R1基团、两个R2基团和两个R3基团可以相同或不同。