8-O-β-D-glucopyranosyl-2-methylchromone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-O-β-D-glucopyranosyl-2-methylchromone
• 化学式: C₁₆H₁₈O₈
• 分子量: 338.314
• InChiKey: BHTUWKRQQFMWOY-XYFZXANASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.72
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  129.59
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  8-O-β-D-glucopyranosyl-2-methylchromone 在 盐酸 作用下， 以 水 为溶剂， 反应 12.0h， 生成 葡萄糖
  参考文献：
  名称：

  8-O-β-D-Glucopyranosyl-2-methylchromone, a new chromone glycoside from the Tibetan medicine plant of Swertia punicea Hemsl

  摘要：

  A new chromone glycoside, 8-O-beta-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant ofSwertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ESI-MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the literature.In vitrotest, all compounds were evaluated for their anti-inflammatory activity through the determination of nitric oxide production. Compounds1-2were evaluated for cytotoxic activities against three human cancer cell lines (HeLa, MDA-MB-231 and A375) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. Furthermore, the chemotaxonomic significance of these compounds has also been described.

  DOI：

  10.1080/14786419.2020.1777123

文献信息

• 8-<i>O</i>-<i>β</i>-D-Glucopyranosyl-2-methylchromone, a new chromone glycoside from the Tibetan medicine plant of <i>Swertia punicea</i> Hemsl
  作者：Lin-Yun Mou、Min Wei、Hai-Yan Wu、Li-Jiao Hu、Jian-Long Li、Gan-Peng Li

  DOI：10.1080/14786419.2020.1777123

  日期：2022.1.2

  A new chromone glycoside, 8-O-beta-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant ofSwertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ESI-MS, 1D and 2D NMR spectroscopic data and comparison with data reported in the literature.In vitrotest, all compounds were evaluated for their anti-inflammatory activity through the determination of nitric oxide production. Compounds1-2were evaluated for cytotoxic activities against three human cancer cell lines (HeLa, MDA-MB-231 and A375) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. Furthermore, the chemotaxonomic significance of these compounds has also been described.