{2-[（4-氯-苯基）-二甲基-甲硅烷基]-苯基}-甲醇 | 1217863-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: {2-[（4-氯-苯基）-二甲基-甲硅烷基]-苯基}-甲醇
• 英文名称: {2-[(4-chlorophenyl)(dimethyl)silyl]phenyl}methanol
• 英文别名: [2-(hydroxymethyl)phenyl]dimethyl(4-chlorophenyl)silane；{2-[(4-Chlorophenyl)dimethylsilyl]phenyl}methanol；[2-[(4-chlorophenyl)-dimethylsilyl]phenyl]methanol
• CAS: 1217863-25-6
• 化学式: C₁₅H₁₇ClOSi
• 分子量: 276.838
• InChiKey: YULOYAUMWFHYQS-UHFFFAOYSA-N

物化性质

• 沸点：
  365.8±42.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  {2-[（4-氯-苯基）-二甲基-甲硅烷基]-苯基}-甲醇 在 甲磺酰溴 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以79%的产率得到[2-(bromomethyl)phenyl](4-chlorophenyl)dimethylsilane
  参考文献：
  名称：

  TW2017/18505

  摘要：

  公开号：
• 作为产物：
  描述：

  dimethyl[2-(2-tetrahydro-2H-pyranoxymethyl)phenyl]silane 以 四氢呋喃 、 甲醇 为溶剂， 生成 {2-[（4-氯-苯基）-二甲基-甲硅烷基]-苯基}-甲醇
  参考文献：
  名称：

  Improved Hiyama cross-coupling reactions using HOMSi®1 reagents: a novel application of a palladacycle

  摘要：

  Various parameters in the Hiyama cross-coupling reaction of HOMSi (R) reagents with ethyl bromobenzoate were studied. These included solvent, ligand, palladium source, and added water. DMF and THF were found to be excellent solvents. Palladium chloride was found to be the best palladium source and no added water was required. The use of tri-o-tolylphosphine as the ligand proved to be particularly effective. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.126

文献信息

• Copper-catalyzed Carboxylation of Unactivated Aryl- and Alkenylsilanes with Carbon Dioxide
  作者：Woo-Jin Yoo、Junpei Kondo、Shū Kobayashi

  DOI：10.1246/cl.190577

  日期：2019.10.5

  A mild synthetic protocol for the preparation of aryl and alkenyl carboxylic acids was developed through a copper-catalyzed carboxylation reaction of organosilanes with carbon dioxide. The key to t...

  通过有机硅烷与二氧化碳的铜催化羧化反应，开发了一种用于制备芳基和烯基羧酸的温和合成方案。关键...
• Copper-Catalyzed Electrophilic Amination of Arylsilanes with Hydroxylamines
  作者：Yuya Miki、Koji Hirano、Tetsuya Satoh、Masahiro Miura

  DOI：10.1021/ol303222s

  日期：2013.1.4

  A copper-catalyzed electrophilic amination of aryl[(2-hydroxymethyl)phenyl]dimethylsilanes with O-acylated hydroxylamines has been developed to afford the corresponding anilines in good yields. The catalytic reaction proceeds very smoothly under mild conditions and tolerates a wide range of functional groups.

  已经开发出铜催化的芳基[（2-羟甲基）苯基]二甲基硅烷与O-酰化的羟胺的亲电胺化，以良好的产率提供相应的苯胺。催化反应在温和条件下进行得非常顺利，并能耐受各种官能团。
• Copper(I)-Catalyzed Alkylation of Aryl- and Alkenylsilanes Activated by Intramolecular Coordination of an Alkoxide
  作者：Akira Tsubouchi、Daisuke Muramatsu、Takeshi Takeda

  DOI：10.1002/anie.201306882

  日期：2013.11.25

  Let's coordinate: Copper(I)‐catalyzed cross‐coupling of alkenyl‐ and arylsilanes with primary alkyl iodides as well as allylic and benzylic halides as C(sp3)X electrophilic coupling partners has been realized by intramolecular activation through alkoxide coordination. This alkylation tolerates a range of functional groups including a free hydroxy group. IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene

  让我们坐标：铜（I）催化的链烯基和芳基硅烷与伯烷基碘以及烯丙基和苄基卤化物如C（SP交叉耦合3）通过醇盐的分子内配位活化已经实现X电偶联伴侣。这种烷基化容许包括游离羟基在内的一系列官能团。IPr = 1,3-双（2,6-二异丙基苯基）咪唑-2-亚烷基。
• Improved Hiyama cross-coupling reactions using HOMSi®1 reagents: a novel application of a palladacycle
  作者：Sebastian M. Marcuccio、Ruwan Epa、Maisa Moslmani、Andrew B. Hughes

  DOI：10.1016/j.tetlet.2011.10.126

  日期：2011.12

  Various parameters in the Hiyama cross-coupling reaction of HOMSi (R) reagents with ethyl bromobenzoate were studied. These included solvent, ligand, palladium source, and added water. DMF and THF were found to be excellent solvents. Palladium chloride was found to be the best palladium source and no added water was required. The use of tri-o-tolylphosphine as the ligand proved to be particularly effective. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
• TW2017/18505
  申请人：——

  公开号：——

  公开（公告）日：——

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