1-(2-aminopropyl)-1-methylhydrazine | 14478-63-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(2-aminopropyl)-1-methylhydrazine
• 英文别名: 1-[Amino(methyl)amino]propan-2-amine
• CAS: 14478-63-8
• 化学式: C₄H₁₃N₃
• mdl: MFCD19204456
• 分子量: 103.167
• InChiKey: IBLUXVYBBLBRNR-UHFFFAOYSA-N

物化性质

• 熔点：
  51-54 °C
• 沸点：
  186.8±23.0 °C(Predicted)
• 密度：
  0.941±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-aminopropyl)-1-methylhydrazine 、 1-苯基-1,2-丙二酮 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 17.0h， 以49%的产率得到6,7-dihydro-1,3,6-trimethyl-4-phenyl-1H-1,2,5-triazepine
  参考文献：
  名称：

  Base-catalysed ring contraction of 6,7-dihydro-1-methyl-1H-1,2,5-triazepines to 2,3-dimethyl-1,2,4-triazines

  摘要：

  6,7-Dihydro-1-methyl-1H-1,2,5-triazepines 3-5 and 8 in ethanolic sodium hydroxide have been converted into one or two compounds of the following types: 1,2,3,6-tetrahydro-6-hydroxy-, 1,2-dihydro- and 2,3-dihydro-2,3-dimethyl-1,2,4-triazines 10-16. In contrast, 1,6-dimethyl analogues are converted into the corresponding 2,3-dihydro-2,3,3-trimethyl-1,2,4-triazines 17-19 under similar conditions. Since alkali hydroxide is essential to the present ring contraction it is likely that it proceeds via a 3-hydroxylated anion formed by hydroxide attack on the 3-position of triazepines 3-9. 1,2,3,6-Tetrahydro-6-hydroxy-2,3-dimethyl-1,2,4-triazines 10-12 are found to be precursors to the 1,2-dihydro-2,3-dimethyl-1,2,4-triazines 13-15.

  DOI：

  10.1039/p19920003233
• 作为产物：
  描述：

  甲基肼 、 2-甲基氮丙啶 生成 1-(2-aminopropyl)-1-methylhydrazine
  参考文献：
  名称：

  具有抗抑郁活性的芳基取代的三嗪。

  摘要：

  DOI：

  10.1021/jm00302a013

文献信息

• 1,4,5,6-Tetrahydro-<i>as</i>-triazines. II. Condensation of β-Aminoalkylhydrazines with Iminoesters and Orthoesters
  作者：Donald L. Trepanier、Jack E. Richman、Allan D. Rudzik

  DOI：10.1021/jm00314a021

  日期：1967.3
• Pomarnacka, Polish Journal of Chemistry, 2007, vol. 81, # 3, p. 345 - 352
  作者：Pomarnacka

  DOI：——

  日期：——
• Aryl-substituted triazines with antidepressant activity
  作者：Donald L. Trepanier、Kenneth L. Shriver、John N. Eble

  DOI：10.1021/jm00302a013

  日期：1969.3
• Base-catalysed ring contraction of 6,7-dihydro-1-methyl-1H-1,2,5-triazepines to 2,3-dimethyl-1,2,4-triazines
  作者：Shinji Shibamoto

  DOI：10.1039/p19920003233

  日期：——

  6,7-Dihydro-1-methyl-1H-1,2,5-triazepines 3-5 and 8 in ethanolic sodium hydroxide have been converted into one or two compounds of the following types: 1,2,3,6-tetrahydro-6-hydroxy-, 1,2-dihydro- and 2,3-dihydro-2,3-dimethyl-1,2,4-triazines 10-16. In contrast, 1,6-dimethyl analogues are converted into the corresponding 2,3-dihydro-2,3,3-trimethyl-1,2,4-triazines 17-19 under similar conditions. Since alkali hydroxide is essential to the present ring contraction it is likely that it proceeds via a 3-hydroxylated anion formed by hydroxide attack on the 3-position of triazepines 3-9. 1,2,3,6-Tetrahydro-6-hydroxy-2,3-dimethyl-1,2,4-triazines 10-12 are found to be precursors to the 1,2-dihydro-2,3-dimethyl-1,2,4-triazines 13-15.