N,N,N',N'-tetrakis-carboxymethyl-L-cystine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N,N',N'-tetrakis-carboxymethyl-L-cystine
• 英文别名: N,N,N',N'-Tetrakis-carboxymethyl-L-cystin；(R:R)-Bis-[2-(bis-carboxymethyl-amino)-2-carboxy-aethyl]-disulfid；N,N,N',N'-tetrakis(carboxymethyl)-L-cystine；(2R)-2-[bis(carboxymethyl)amino]-3-[[(2R)-2-[bis(carboxymethyl)amino]-2-carboxyethyl]disulfanyl]propanoic acid
• 化学式: C₁₄H₂₀N₂O₁₂S₂
• 分子量: 472.451
• InChiKey: IIFWGMQXKAQOOT-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  30
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  281
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-tetrakis-carboxymethyl-L-cystine 在 水 、 溴 作用下， 生成 N,N-bis-carboxymethyl-cysteic acid ; N,N-bis-carboxymethyl-L-cysteic acid
  参考文献：
  名称：

  Michaelis; Schubert, Journal of Biological Chemistry, 1934, vol. 106, p. 340

  摘要：

  DOI：
• 作为产物：
  描述：

  L-胱氨酸 、 碘乙酸 在 氢氧化钾 作用下， 生成 N,N,N',N'-tetrakis-carboxymethyl-L-cystine
  参考文献：
  名称：

  Michaelis; Schubert, Journal of Biological Chemistry, 1934, vol. 106, p. 340

  摘要：

  DOI：

文献信息

• Method of generating metal chelating affinity ligands
  申请人：Andersson C. Lars

  公开号：US20060027501A1

  公开（公告）日：2006-02-09

  The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities are protected, on each scaffold by derivatisation of the nucleophile of said scaffolds, while retaining the cyclic structure of the scaffold; (c) ring-opening at the bond between the carbonyl and the sulphur of the derivatised scaffold by adding a reagent that adds one or more metal chelating affinity ligand arms to the scaffold; and, if required, (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment of the method, steps (c) and (d) are performed simultaneously as one single step.

  本发明涉及一种生成至少一种多螯合金属螯合亲和配体的方法，该方法包括以下步骤：(a)提供至少一个环状支架，其中包括一个羰基、一个相邻的硫和一个亲核物；(b)通过衍生化所述支架的亲核物，在每个支架上提供至少一个多螯合金属螯合亲和配体臂，可选地以保护金属螯合功能的形式；同时保留支架的环状结构；(c)通过添加一个试剂，在衍生化的支架的羰基和硫之间的键处开环，将一个或多个金属螯合亲和配体臂添加到支架上；如果需要，(d)去除步骤(b)中提供的配体臂的功能保护基。在最优选的实施方式中，步骤(c)和(d)同时进行为一步。
• Preparation of a metal chelating separation medium
  申请人：Andersson C. Lars

  公开号：US20060199950A1

  公开（公告）日：2006-09-07

  The present invention relates to the preparation of a metal chelating separation medium, which comprises providing a compound defined by formula: R—O—CO—(CH 2 ) n —CHNH 2 —CO—OH wherein R is a selectively cleavable group; and n is an integer of 1-4; reacting it with ethyl alcohol; derivatisation; cleavage of R; immobilisation of the resulting compound to a base matrix; and deprotection of the carboxylic acid. In one embodiment, the compound provided in the first step is ethyl ester of aspartic acid or of glutamic acid, and the derivatisation agent is bromo-acetic acid ethyl acetate.

  本发明涉及制备金属螯合分离介质的方法，包括提供一个由以下式子定义的化合物：R—O—CO—(CH2)n—CHNH2—CO—OH，其中R是一个可选择性断裂的基团；n是1-4的整数；将其与乙醇反应；衍生化；断裂R；将所得化合物固定到基质上；并去保护羧酸。在一种实施例中，第一步中提供的化合物是天冬氨酸或谷氨酸的乙酯，衍生化试剂是溴乙酸乙酯。
• Method for generating metal chelating affinity ligands
  申请人：GE Healthcare Bio-Sciences AB

  公开号：US07988858B2

  公开（公告）日：2011-08-02

  The present invention relates to a method for generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one scaffold defined by the general formula (I): H2N—(X1)n—S—S—(X2)m—CH2—NH2 wherein X1 and X2 irrespective of each other are carbon atoms or heteroatoms, and n and m irrespective of each other are integers of 1 to 5; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities of at least one arm are protected, on each scaffold by derivatisation of the nucleophilic NH2 groups of the scaffold; (c) reducing the disulfide bond of the derivatised scaffold; and, if required (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment, the reduction of the disulfide bond and the deprotection step is performed essentially simultaneously.

  本发明涉及一种生成至少一种多齿金属螯合亲和配体的方法，该方法包括以下步骤：(a)提供至少一个由通式(I)定义的支架：H2N—(X1)n—S—S—(X2)m—CH2—NH2，其中X1和X2无论如何都是碳原子或杂原子，n和m无论如何都是1到5的整数；(b)通过衍生化支架的亲核NH2基团，在每个支架上提供至少一个多齿金属螯合亲和配体臂，可选地以至少一个臂的金属螯合官能团被保护的形式；(c)还原衍生化支架的二硫键；如果需要，(d)去保护步骤(b)中提供的配体臂的官能团。在最优选实施例中，还原二硫键和去保护步骤是基本同时进行的。
• METHOD FOR GENERATING METAL CHELATING AFFINITY LIGANDS
  申请人：Axen Andreas

  公开号：US20090200239A1

  公开（公告）日：2009-08-13

  The present invention relates to a method for generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one scaffold defined by the general formula (I): H 2 N—(X 1 ) n —S—S—(X 2 ) m —CH 2 —NH 2 wherein X 1 and X 2 irrespective of each other are carbon atoms or heteroatoms, and n and m irrespective of each other are integers of 1 to 5; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities of at least one arm are protected, on each scaffold by derivatisation of the nucleophilic NH 2 groups of the scaffold; (c) reducing the disulfide bond of the derivatised scaffold; and, if required (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment, the reduction of the disulfide bond and the deprotection step is performed essentially simultaneously.

  本发明涉及一种生成至少一种多配位金属螯合亲和配体的方法，该方法包括以下步骤：(a)提供至少一种由通式(I)定义的支架：H2N—(X1)n—S—S—(X2)m—CH2—NH2，其中X1和X2无论如何都是碳原子或杂原子，n和m无论如何都是1到5的整数；(b)通过衍生化支架的亲核NH2基团，在每个支架上提供至少一种多配位金属螯合亲和配体臂，可选地，其中至少一个臂的金属螯合功能被保护；(c)还原衍生化支架的二硫键；如果需要，(d)去保护步骤(b)中提供的配体臂的功能。在最优选实施方式中，还原二硫键和去保护步骤是基本同时进行的。
• Metal chelating compositions
  申请人：Sigma Aldrich Company

  公开号：EP1627683A2

  公开（公告）日：2006-02-22

  A metal chelating composition having the formula:     wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)-; A is an amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is -(CH2)kCOOH; k is an integer from 0 to 2; Y is -COOH; Z is -COOH; and i is an integer from 0 to 4.

  一种金属螯合组合物，其化学式为 其中 Q 是载体 S1 是间隔物 L 是-A-T-CH(X)-； A 是酰胺连接 T 是键或取代或未取代的烷基或烯基； X 是-(CH2)kCOOH； k 是 0 至 2 的整数； Y 是-COOH Z 是-COOH i 是 0 至 4 的整数。