Synthesis, Optical, and Electroluminescent Properties of Alternating Copolymer Based on Phenothiazine and Fluorene with Oxadiazole Pendant
摘要:
A new alternating copolymer based on phenothiazine-fluorene with aromatic 1,3,4-oxadiazole (OXD) as a side chain (poly(10-{4-[5-(4-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl}-phenothiazine-3,7-diyl-alt-9,9-dihexyl-2,7-fluorene, PTOXDPF) was synthesized by the Suzuki coupling reaction. The maximum absorption wavelength of PTOXDPF solution showed at 410 nm which was dramatically blue-shifted than that of the polymer without OXD (poly(10-hexylphenothiazine-3,7-diyl-alt-9,9-dihexyl-2,7-fluorene, PTPF). This is due to that the presence of OXD pendant reduces the possibility of inter-chain interactions. The HOMO energy level of PTOXDPF estimated from the cyclic voltammetry was -5.13 eV, which was similar to the polymer without OXD pendant (PTPF). The OXD pendant does not affect HOMO energy level significantly. This is due to that oxidation potential of PTOXDPF dominated by the phenothiazine unit. The maximum efficiency and brightness of the electroluminescent (EL) device based on PTOXDPF (ITO/PEDOT/PTOXDPF/Al) were 45.4 cd/m(2) and 5.21 x 10(-2) cd/A, which were dramatically higher than PTPF (2.65 cd/m(2) and 1.32 x 10(-3) cd/A). This is presumably due to that the OXD pendant in PTOXDPF improves the electron transporting ability in the emissive layer.
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
作者:Katharina Vögerl、Nghia Ong、Johanna Senger、Daniel Herp、Karin Schmidtkunz、Martin Marek、Martin Müller、Karin Bartel、Tajith B. Shaik、Nicholas J. Porter、Dina Robaa、David W. Christianson、Christophe Romier、Wolfgang Sippl、Manfred Jung、Franz Bracher
DOI:10.1021/acs.jmedchem.8b01090
日期:2019.2.14
lines. Structure-activityrelationshipstudies revealed that incorporation of a nitrogen atom into the phenothiazine framework results in increased potency and selectivity for HDAC6 (more than 500-fold selectivity relative to the inhibition of HDAC1, HDAC4, and HDAC8), as rationalized by molecular modeling and docking studies. The binding mode was confirmed by co-crystallization of the potent azaphenothiazine
Enhancing photocatalytic performance of atom transfer radical addition (ATRA) reactions in water using immobilized 10-Phenylphenothiazine catalysts on mesoporous silica supports
作者:Montaña J. García、Thomas A. Comerford、Carmen Montoro、Eli Zysman-Colman、José Alemán、Silvia Cabrera
DOI:10.1016/j.jcat.2024.115368
日期:2024.3
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The Metalation of 10-Phenylphenothiazine and of 10-Ethylphenothiazine<sup>1</sup>