N,N-bis(2-p-tolylsulfonyloxyethyl)aniline | 3590-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-bis(2-p-tolylsulfonyloxyethyl)aniline
• 英文别名: 3-phenyl-1,5-bis(p-toluenesulfonyloxy)-3-azapentane；2,2'-(phenylazanediyl)bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)；N,N-bis[2-(p-tolylsulfonoxy)ethyl]benzenamine；2,2'-(phenylimino)bis[ethanol] bis(4-methylbenzenesulfonate)；1,5-bis(p-tolylsulfonyloxy)-3-phenyl-3-azapentane；N,N-bis[2-(p-toluenesulfonyloxy)ethyl]-N-phenylamine；1,5-di(4-toluenesulfonyloxy)-3-phenyl-3-azapentane；N,N-bis[2-(p-tolylsulfonoxyl)ethyl]benzenamine；N,N-bis[2-(p-toluenesulfonyl)ethyl]benzamine；N-phenyldiethanolamine ditosylate；N,N-bis[2-(p-toluenesulfonoxy)ethyl]phenylamine；2.2'-Phenylimino-diaethyl-di-p-toluolsulfonat；N,N-bis(2-(p-toluenelylsulfonyl)ethyl)aniline；N,N-bis[2-(p-tolylsulfonoxy)ethyl]phenylamine；N,N-bis(2-tosyloxyethyl)aniline；2-(Phenylimino)diethanol di-p-toluenesulfonate；2-[N-[2-(4-methylphenyl)sulfonyloxyethyl]anilino]ethyl 4-methylbenzenesulfonate
• CAS: 3590-12-3
• 化学式: C₂₄H₂₇NO₆S₂
• 分子量: 489.613
• InChiKey: CATMAHFPKNTCAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  N,N-bis(2-p-tolylsulfonyloxyethyl)aniline 在 sodium iodide 作用下， 以 丙酮 为溶剂， 以87%的产率得到N,N-二(2-碘乙基)苯胺
  参考文献：
  名称：

  Silver Ion Selective Extraction with Dithiaza-, Tetrathiaza-, and Tetrathiadiazacrown Ether Derivatives

  摘要：

  合成了二硫氮杂冠醚、四硫氮杂冠醚以及两种四硫二氮杂冠醚衍生物，这些化合物在每一个氮原子外围都带有一个苯基。使用水-1,2-二氯乙烷系统，研究了这些化合物对某些过渡金属离子的萃取。所有这些硫氮杂冠醚化合物都对银离子有选择性，并且形成了银离子：配体：月桂酸离子1:1:1的络合物，作为被萃取到1,2-二氯乙烷溶液中的反离子。银离子的萃取能力（萃取常数，Kex）按以下顺序递减：7,16-二苯基四硫-7,16-二氮杂-18-冠-6（3）（log Kex = 1.18 ± 0.13）> 13-苯基四硫-13-氮杂-15-冠-5（2）（0.75 ± 0.09）> 7-苯基二硫-7-氮杂-9-冠-3（1）（−0.47 ± 0.06）> 13,16-二苯基四硫-13,16-二氮杂-18-冠-6（4）（−0.62 ± 0.16）。

  DOI：

  10.1246/bcsj.68.2831
• 作为产物：
  描述：

  N,N-二羟乙基苯胺 在 吡啶 、 对甲苯磺酰氯 作用下， 以80%的产率得到N,N-bis(2-p-tolylsulfonyloxyethyl)aniline
  参考文献：
  名称：

  Epoxy-based oligomer containing dithia-aza-based naphthylazobenzene pendant: a chemosensor for Hg²⁺and Cu²⁺ions

  摘要：

  A simple epoxy-based oligomer 1 containing naphthylazobenzene-appended dithia-aza moieties was prepared. In UV-vis measurements, the proposed oligomer showed the ion-sensing ability to Hg2+ and Cu2+ ions. The discrimination between two differently responding Hg2+ and Cu2+ ions was also realised from 'ON-OFF' type fluorescence responses of 1.

  DOI：

  10.1080/10610278.2011.575469

文献信息

• Hg2+ sensing in aqueous solutions: an intramolecular charge transfer emission quenching fluorescent chemosensors
  作者：Sin-Man Cheung、Wing-Hong Chan

  DOI：10.1016/j.tet.2006.06.035

  日期：2006.8

  functionalities as ligating groups, were designed as fluorescent chemosensors for Hg(II). In aqueous solvent systems, upon excitation, in addition to the normal emission bands of locally excited (LE) state of anthracene, both compounds show a prominent pH-independent intramolecular charge transfer (ICT) emissive band, which can be modulated by Hg2+ binding. The systems can be exploited to develop a fluorescent

  将包含蒽部分作为荧光团和一对二硫代氨基甲酸酯官能团作为连接基团的化合物4a和4b设计为Hg（II）的荧光化学传感器。在水性溶剂系统中，在激发后，除了蒽的局部激发（LE）态的正常发射带外，两种化合物均显示出显着的非pH依赖性分子内电荷转移（ICT）发射带，可通过Hg 2+对其进行调节捆绑。可以利用该系统开发Hg 2+的荧光敏感探针。
• Synthesis, characterization and theoretical investigations of molybdenum carbonyl complexes with phosphorus/nitrogen/phosphorus ligand as bidentate and tridentate modes
  作者：Seyma Goren Keskin、Julie M. Stanley、Alan H. Cowley

  DOI：10.1016/j.poly.2017.09.037

  日期：2017.12

  Abstract Carbonyl complexes of molybdenum with the phosphorus/nitrogen/phosphorus ligand, PNP-Mo(CO)n, where n = 3, 4 and PNP is N,N-bis[2-(diphenylphosphino)ethyl]phenylamine have been synthesized and characterized by 1H, 31P1H} NMR, IR (ATR and solution state), Raman, X-ray diffraction, MS and elemental analysis. DFT calculations of the complexes were also performed. The PNP-Mo(CO)4 complex in which

  摘要合成了具有磷/氮/磷配体PNP-Mo（CO）n的钼羰基配合物，其中n = 3、4，PNP为N，N-双[2-（二苯基膦基）乙基]苯胺。 1H，31P 1H} NMR，IR（ATR和溶液状态），拉曼光谱，X射线衍射，MS和元素分析。还进行了配合物的DFT计算。获得了结合方式为二齿顺膦的PNP-Mo（CO）4络合物，以及结合方式为三齿的PNP-Mo（CO）3的面和子午异构体。面部异构体和四羰基配合物已成功合成和纯化。但是，不可能分离出子午异构体。仅检测到子午异构体的少数晶体，并将其用于X射线分析。当面部异构体溶解在CH2Cl2或THF中时，发现它发生分解，从而生成四羰基络合物，子午异构体，Mo（0），为深色沉淀，以及一些残留在溶液中的面部异构体。还研究了面部异构体相对于子午异构体是优选结构的原因。
• Hydrazones Derived from Dithiamonoaza and Tetrathiamonoaza Analogs of Polyethers as Silver Ion Selective Ionophores: Syntheses, Proton-Dissociation Behaviors, and Metal Ion Complexing Properties in 1,4-Dioxane–Water Acidic Solution
  作者：Junichi Ishikawa、Hidefumi Sakamoto、Tamao Mizuno、Makoto Otomo

  DOI：10.1246/bcsj.68.3071

  日期：1995.11

  Cyclic and acyclic dithiamonoaza, tetrathiamonoaza, and tetrathiadiaza analogs of polyethers bearing a hydrazone moiety on nitrogen atom(s) were synthesized. Their acidity constants in 1,4-dioxane–water solution and stability constants of hydrazones derived from dithiamonoaza and tetrathiamonoaza analogs of polyethers for some heavy metal ions in same acidic media were measured spectrophotometrically

  合成了在氮原子上带有腙部分的聚醚的环状和非环状二硫单氮杂、四硫单氮杂和四硫二氮杂类似物。它们在 1,4-二氧六环 - 水溶液中的酸度常数和衍生自聚醚的二硫单氮杂和四硫单氮杂类似物的腙在相同酸性介质中对某些重金属离子的稳定性常数进行了分光光度法测量。环状和非环状四硫单氮杂系列的腙具有高度的 Ag+ 选择性络合性。
• α-Glucosidase inhibition and antihyperglycemic activity of flavonoids from Ampelopsis grossedentata and the flavonoid derivatives
  作者：Jia Chen、Yuechan Wu、Jianwei Zou、Kun Gao

  DOI：10.1016/j.bmc.2016.02.018

  日期：2016.4

  known major components (1–3) were isolated by recrystallization process and six new derivatives (4–9) were obtained by etherification of the bioactive flavonoid. All compounds were evaluated for their inhibitory activities against α-glucosidase (from Saccharomyces cerevisiae). As a result, compound 9 showed a significant α-glucosidase inhibitory activity with IC50 value of 9.3 μM and acted as a competitive

  干燥的叶子和茎藤茶已被用来作为保健茶和草药数百年来，在中国。该研究的目的是在猪牙菌及其衍生物中最丰富的成分中寻找新型的α-葡萄糖苷酶抑制剂。三种已知的主要组分（1 - 3）通过重结晶过程和六个新的衍生物（隔绝4 - 9由生物活性的类黄酮的醚化获得）。评价所有化合物对α-葡糖苷酶（来自酿酒酵母）的抑制活性。结果，化合物9表现出显着的α-葡萄糖苷酶抑制活性，IC 50值为9.3μM，并作为竞争性抑制剂，抑制常数（K i）值为10.3μM。以50mg / kg的剂量口服施用化合物9显着降低正常和链脲佐菌素（STZ）诱导的糖尿病小鼠的餐后血糖水平。此外，化合物9显着降低了STZ诱导的糖尿病小鼠的空腹血糖水平。
• Molybdenum dinitrogen complexes facially coordinated by linear tridentate PEP ligands (E = N or P): impact of the central E donor in trans-position to N₂
  作者：Svea Hinrichsen、Ann-Christin Schnoor、Katharina Grund、Benedikt Flöser、Alexander Schlimm、Christian Näther、Jan Krahmer、Felix Tuczek

  DOI：10.1039/c6dt02316a

  日期：——

  The syntheses of molybdenum dinitrogen complexes supported by the tridentate PEP ligands (E = N, P) prPP(Ph)P = (Ph2PCH2CH2CH2)2P(Ph), prPPHP = (Ph2PCH2CH2CH2)2PH, PN(Ph)P = (Ph2PCH2CH2)2N(Ph) and prPN(Ph)P = (Ph2PCH2CH2CH2)2N(Ph) are reported. Together with the coligand dmpm = (CH3)2PCH2P(CH3)2 dinitrogen complexes of the type [Mo(N2)(PEP)(dmpm)] are formed. The new systems are characterized by IR

  三齿PEP配体（E = N，P）prPP（Ph）P =（Ph 2 PCH 2 CH 2 CH 2）2 P（Ph），prPPHP =（Ph 2 PCH 2 CH 2报告了CH 2）2 PH，PN（Ph）P =（Ph 2 PCH 2 CH 2）2 N（Ph）和prPN（Ph）P =（Ph 2 PCH 2 CH 2 CH 2）2 N（Ph）。连同大肠菌dmpm =（CH 3）2 PCH形成类型为[Mo（N 2）（PEP）（dmpm）]的2 P（CH 3） 2二氮配合物。新系统的特征在于IR和NMR光谱，并与文献中已知的复合物[Mo（N 2）（dpepp）（dmpm）]（ 1）（dpepp = PhP（CH 2 CH 2 PPh 2） 2）进行了比较。关于相应N 2的稳定性，研究了用N取代dpepp的中心P-供体和用C 3键取代其C 2以及通过EH功能交换EPh的后果。-复杂。重要的是，当用反式胺供体代替反式膦时，N