vinyl linoleate | 3234-56-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: vinyl linoleate
• 英文别名: Vinyl linoleate；ethenyl (9Z,12Z)-octadeca-9,12-dienoate
• CAS: 3234-56-8
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: DKFQQHOQRBDQQY-MURFETPASA-N

物化性质

• 沸点：
  148-150 °C(Press: 0.75 Torr)
• 密度：
  0.889±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  vinyl linoleate 、 1-Myristoyl-3-β-D-galactosyl-sn-glycerol 在 Mucor jaranicus lipase (lipase M) 作用下， 以 二氯甲烷 为溶剂， 反应 96.0h， 以85%的产率得到[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[(2S)-2-hydroxy-3-tetradecanoyloxypropoxy]oxan-2-yl]methyl (9Z,12Z)-octadeca-9,12-dienoate
  参考文献：
  名称：

  Chemoenzymatic synthesis of 1-O-acyl-3-O-(6'-O-acyl-β-D-galactopyranosyl)-sn-glycerol

  摘要：

  Convenient synthesis of 1-O-acyl-3-O-(6'-O-acyl-beta-D-galactopyranosyl)-sn-glycerol was studied. The lipase from Achromobacter sp, catalyzed acylation of 3-O-beta-D-galactopyranosyl-sn-glycerol, which contains two primary hydroxyl functions, proceeded regioselectively to furnish 1-O-acyl-3-O-beta-D-galactopyranosyl-sn-glycerol.

  DOI：

  10.1016/0040-4020(95)00299-n
• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 、 乙炔 在 zinc linolenate 、 甲苯 作用下， 200.0 ℃ 、2.94 MPa 条件下， 生成 vinyl linoleate
  参考文献：
  名称：

  Embolotherapy for myoma-induced menorrhagia

  摘要：

  Uterine fibroids are a common cause of abnormal uterine bleeding. Uterine artery embolization has proven to be highly effective in controlling fibroid related menorrhagia and triggering tumor degeneration.

  DOI：

  10.1016/s0889-8545(00)80030-3

文献信息

• Enzymatic Regioselective Acylation of 3-O-.BETA.-D-Galactopyranosyl-sn-glycerol by Achromobacter sp. Lipase.
  作者：Takashi MORIMOTO、Nobutoshi MURAKAMI、Akito NAGATSU、Jinsaku SAKAKIBARA

  DOI：10.1248/cpb.42.751

  日期：——

  Achromobacter sp. lipase regioselectively acylated the hydroxyl group on sn-1 carbon among the two primary hydroxyl groups of 3-O-β-D-galactopyranosyl-sn-glycerol.

  Achromobacter sp. 脂肪酶选择性地对3-O-β-D-半乳糖吡喃糖基-sn-甘油的两个主要羟基中的sn-1碳上的羟基进行了酰化。
• Enzymatic esterification of glycerol III. Lipase‐catalyzed synthesis of regioisomerically pure 1,3‐<i>sn</i>‐diacylglycerols and 1 (3)‐<i>rac</i>‐monoacylglycerols derived from unsaturated fatty acids
  作者：Claudia Waldinger、Manfred Schneider

  DOI：10.1007/bf02523518

  日期：1996.11

  Lipases that display high regioselectivities and broad substrate tolerance were used as catalysts for the efficient esterification of glycerol under the conditions of irreversible acyl transfer. A variety of unsaturated fatty acids, such as oleic, linoleic, erucic, ricinolic, hydroxystearic and coriolic acid, were used for this purpose in the form of their vinyl esters. Suitable biocatalysts were chosen on the basis of systematic screening experiments regarding their regioselectivities (RE) and substrate tolerances. Distinct differences were found and expressed in numerical RE values as a measure for differences of these biocatalysts as being specific, selective, and nonspecific. Based on these experiments, a variety of molecules were synthesized on a preparative scale (>150 mmol) in good yield (ca.85%) and with high regioisomerical purities (>95% RE).

  摘要 利用具有高区域选择性和广泛底物耐受性的脂肪酶作为催化剂，在不可逆酰基转移条件下对甘油进行高效酯化。油酸、亚油酸、芥酸、蓖麻酸、羟基硬脂酸和科里奥利酸等多种不饱和脂肪酸以乙烯基酯的形式被用于此目的。在对生物催化剂的区域选择性（RE）和底物耐受性进行系统筛选的基础上，选择了合适的生物催化剂。实验发现，这些生物催化剂在特异性、选择性和非特异性方面存在明显差异，并以 RE 数值表示。在这些实验的基础上，以制备规模（150 毫摩尔）合成了多种分子，产率高（约 85%），区域异构纯度高（95% RE）。
• Carbohydrate Esters as Inducers for Gene Expression
  申请人：Sophoro Biotechnologies, LLC

  公开号：US20150152462A1

  公开（公告）日：2015-06-04

  The invention provides novel carbohydrate esters, in particular disaccharide esters, and the methods of their preparation. These compounds find use as microbial media components for the induction of gene expression in microbial fermentation processes.

  这项发明提供了新型的碳水化合物酯，特别是二糖酯，以及它们的制备方法。这些化合物可作为微生物发酵过程中诱导基因表达的微生物培养基组分。
• MEMBRANE FUSION INHIBITOR
  申请人：Kaihatsu Kunihiro

  公开号：US20110003889A1

  公开（公告）日：2011-01-06

  The present invention provides a pharmaceutical composition that has excellent safety and targets a different step in the virus propagation cycle than conventional pharmaceutical compositions, applicable as an antiviral agent. A pharmaceutical composition containing an epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is prepared. This can be used as a membrane fusion inhibitor that inhibits viral membrane fusion. In the following formula, R 1 to R 6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of R 1 to R 6 is the acyl group. R 7 to R 16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.

  本发明提供了一种药物组合物，具有优异的安全性，并且针对病毒传播周期中不同的步骤，适用于抗病毒药剂。制备了一种含有以下化学式（1）所表示的表沙黄酮酸酯衍生物、其异构体或其盐的药物组合物。它可以用作抑制病毒膜融合的膜融合抑制剂。在下面的公式中，R1到R6分别是氢原子、卤素、钠、钾或直链或支链、饱和或不饱和的酰基，可以相同或不同。酰基还可以进一步取代一个或多个取代基。其中至少一个是酰基。R7到R16分别是氢原子、卤素、钠或钾，可以相同或不同。
• BETA-1,3-GLUCAN DERIVATIVE AND METHOD FOR PRODUCING BETA-1,3-GLUCAN DERIVATIVE
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20150299339A1

  公开（公告）日：2015-10-22

  An object of the present invention is to provide a β-1,3-glucan derivative which is a polymer having β-1,3-glucan as a main chain, and has thermoplasticity and excellent moldability, and a preparation method thereof. That is, the present invention provides a β-1,3-glucan derivative having a structure represented by General Formula (1) as a main chain. (In Formula (1), each of a plurality of R 1 s independently represents a hydrogen atom or —COR 2 , n represents an integer of 1 or greater, and R 2 represents an aliphatic hydrocarbon group or an aromatic hydrocarbon group. In Formula (1), a plurality of the R 1 s may be the same as or different from each other, and at least a part of a plurality of the R 1 s is —COR 2 .)

  本发明的目的是提供一种β-1,3-葡聚糖衍生物，其作为主链具有β-1,3-葡聚糖，并具有热塑性和优异的可塑性，以及其制备方法。也就是说，本发明提供了一种以通式（1）表示结构的β-1,3-葡聚糖衍生物作为主链。（在公式（1）中，多个R1独立地表示氢原子或-COR2，n表示大于等于1的整数，而R2表示脂肪烃基或芳香烃基。在公式（1）中，多个R1可以相同或不同，而多个R1中的至少一部分是-COR2。）