4-(4-pentenyl)veratrole | 116174-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-pentenyl)veratrole
• 英文别名: 5-(3,4-dimethoxyphenyl)-1-pentene；1,2-Dimethoxy-4-(pent-4-EN-1-YL)benzene；1,2-dimethoxy-4-pent-4-enylbenzene
• CAS: 116174-28-8
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: NGRJWXATUJITML-UHFFFAOYSA-N

物化性质

• 沸点：
  282.7±25.0 °C(Predicted)
• 密度：
  0.960±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-pentenyl)veratrole 在 m-chloroperoxybenzoic acid 作用下， 以 二氯甲烷 为溶剂， 生成 3-(3,4-dimethoxyphenyl)propyloxirane
  参考文献：
  名称：

  Alpha-(phenylalkyl) pyridinealkanol derivatives

  摘要：

  本发明涉及一种新颖的对疾病或障碍介导的α-(苯基烷基)吡啶烯醇衍生物，用于治疗由血小板活化因子介导的疾病或障碍。本发明还涉及这种α-(苯基烷基)吡啶烯醇衍生物的药物组合物。

  公开号：

  EP0267439A3
• 作为产物：
  描述：

  1-(3,4-dimethoxyphenyl)pent-4-en-1-one 在 盐酸 、 锌 作用下， 以 乙醇 、 水 为溶剂， 反应 16.0h， 以85%的产率得到4-(4-pentenyl)veratrole
  参考文献：
  名称：

  Bioactive alkenylphenols from Piper obliquum

  摘要：

  Various parts of Piper obliquum Ruiz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappa B activity by targeting early events in the TNF alpha-induced NF-kappa B inflammatory pathway, which may explain the effects reported for the traditional use of the plant. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.01.018

文献信息

• Anionic Reactions ofN-(trans-2,3-Diphenylaziridin-1-yl)imines and Their Use as 1,1-Dipoles in Anionic Cyclizations
  作者：Jung-ll Hwang、Young-Taek Hong、Sunggak Kim

  DOI：10.1002/adsc.200505110

  日期：2005.10

  Reaction of N-(trans-2,3-diphenylaziridin-1-yl)imines with alkyllithiums and organocuprates afforded the desired addition products after consecutive fragmentations along with liberation of stilbene and nitrogen gas, while the reaction of N-(2-phenylaziridin-1-yl)imines under similar conditions gave an anomalous by-product. Anionic cyclizations of N-(trans-2,3-diphenylaziridin-1-yl)imines using unactivated

  的反应ñ - （反式-2,3- diphenylaziridin -1-基）亚胺用，得到所需的加成产物与芪和氮气的解放沿着连续分片之后烷基锂和有机铜，而反应ñ - （2- phenylaziridin-在类似条件下的1-yl）亚胺产生异常的副产物。使用未活化的烯烃和炔烃作为受体，N-（反式-2,3-二苯基叠氮基-1-基）亚胺的阴离子环化反应顺利进行，从而以高收率得到环化产物。
• Bioactive alkenylphenols from Piper obliquum
  作者：Carola Valdivia、Nieves Marquez、John Eriksson、Antonio Vilaseca、Eduardo Muñoz、Olov Sterner

  DOI：10.1016/j.bmc.2008.01.018

  日期：2008.4.1

  Various parts of Piper obliquum Ruiz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappa B activity by targeting early events in the TNF alpha-induced NF-kappa B inflammatory pathway, which may explain the effects reported for the traditional use of the plant. (C) 2008 Elsevier Ltd. All rights reserved.
• Alpha-(phenylalkyl) pyridinealkanol derivatives
  申请人：——

  公开号：EP0267439A3

  公开（公告）日：1988-08-31

  This invention relates to novel a-(phenylalkyl) pyridinealkanol derivatives useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention further relates to pharmaceutical compositions of such a-(phenylalkyl)pyridinealkanol derivatives.

  本发明涉及一种新颖的对疾病或障碍介导的α-(苯基烷基)吡啶烯醇衍生物，用于治疗由血小板活化因子介导的疾病或障碍。本发明还涉及这种α-(苯基烷基)吡啶烯醇衍生物的药物组合物。