N-苯基磺酰基-4-硝基苯胺 | 6596-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-苯基磺酰基-4-硝基苯胺
• 英文名称: N'-phenylbenzenesulfonohydrazide
• 英文别名: N^β-Phenyl-benzolsulfonsaeurehydrazid
• CAS: 6596-69-6
• 化学式: C₁₂H₁₂N₂O₂S
• 分子量: 248.305
• InChiKey: NLEOEXCPIKOHJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  N-苯基磺酰基-4-硝基苯胺 在 sodium hydroxide 作用下， 生成 苯亚磺酸
  参考文献：
  名称：

  Escales, Chemische Berichte, 1885, vol. 18, p. 893

  摘要：

  DOI：
• 作为产物：
  描述：

  苯肼 在 二甲胺基磺酰氯 作用下， 以 苯 为溶剂， 生成 N-苯基磺酰基-4-硝基苯胺
  参考文献：
  名称：

  取代的肼与氨磺酰卤之间的自由基反应

  摘要：

  DOI：

  10.1016/s0040-4039(01)98795-7

文献信息

• [EN] HYDRAZIDE DERIVATIVES AND THEIR SPECIFIC USE AS ANTIBACTERIAL AGENTS BY CONTROLLING ACINETOBACTER BAUMANNII BACTERIUM<br/>[FR] DÉRIVÉS D'HYDRAZIDE ET LEUR UTILISATION SPÉCIFIQUE EN TANT QU'AGENTS ANTIBACTÉRIENS POUR LUTTER CONTRE UNE BACTÉRIE ACINETOBACTER BAUMANNII
  申请人：YNCREA HAUTS DE FRANCE

  公开号：WO2020169682A1

  公开（公告）日：2020-08-27

  The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, their use as a drug, in particular as antibacterial agent, notablyforpreventingand/or treating disorders associated to Acinetobacter baumannii. The present invention also relates to pharmaceutical compositions containing said compoundsand the process for preparing said compounds.

  本发明涉及以下一般式（I）的化合物，或其药学上可接受的盐和/或溶剂，其用作药物，特别是作为抗菌剂，尤其用于预防和/或治疗与鲍曼不动杆菌相关的疾病。本发明还涉及含有上述化合物的药物组合物以及制备上述化合物的方法。
• Iodine-mediated aryl transfer reaction from arylhydrazine hydrochlorides to nitriles
  作者：Zhiguo Zhang、Xiang Li、Yinghua Li、Yan Guo、Xunan Zhao、Yan Yan、Kai Sun、Guisheng Zhang

  DOI：10.1016/j.tet.2019.05.034

  日期：2019.6

  An iodine-promoted, metal-, base-, and solvent-free cross-coupling reaction was developed for the synthesis of various useful secondary amides via an aryl N-addition reaction of aryl groups to cyano groups. This aryl transfer reaction proceeds with arylhydrazine hydrochlorides serving as the aryl donors. A labelling experiment shows that the N atom in the product comes from the cyano group of the nitriles

  通过芳基与氰基的芳基N加成反应，开发了碘促进的，无金属，无碱和无溶剂的交叉偶联反应，用于合成各种有用的仲酰胺。该芳基转移反应与用作芳基供体的芳基肼盐酸盐一起进行。标记实验表明，产物中的N原子来自腈的氰基，它们的成本较低。还提出了一种可行的自由基驱动机制。
• PPAR-gamma modulator
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030134859A1

  公开（公告）日：2003-07-17

  A compound of the following formula or a pharmacologically acceptable salt thereof: 1 wherein A represents a phenyl group or the like, B represents an aryl group or the like, X represents an oxygen atom or the like, and n represents 0 or 1. The compound is a PPAR &ggr; modulator which is a therapeutic agent for retrograde osteoporosis in which excessive differentiation of adipocytes is inhibited and formation and differentiation of osteoblasts from stem cells is facilitated, and for diabetes mellitus without characteristics such as excessive adipogenesis, liver dysfunction, vascular disorders, heart diseases and the like.

  以下化学式的化合物或其药理学上可接受的盐：其中A代表苯基或类似物，B代表芳基或类似物，X代表氧原子或类似物，n代表0或1。该化合物是一种PPAR &ggr; 调节剂，用于治疗逆行性骨质疏松症，通过抑制脂肪细胞的过度分化并促进干细胞向成骨细胞的形成和分化，以及用于糖尿病而不具有过度脂肪生成、肝功能障碍、血管紊乱、心脏疾病等特征。
• An Efficient Synthesis of Sulfonylhydrazides and Sulfonylsemicarbazides by Utilizing Alumina as a Catalyst
  作者：Javad Safaei-Ghomi

  DOI：10.1002/jccs.200700220

  日期：2007.12

  Sulfonyl hydrazides and sulfonyl semicarbazides are readily prepared by the reacting of hydrazine derivatives with sulfonyl chlorides in the presence of basic alumina under solvent-free conditions. Reaction of a sulfonyl chloride with t-butylcarbazate, followed by hydrolysis provides the corresponding sulfonyl hydrazides in higher yield and shorter time than previously reported.

  磺酰肼和磺酰氨基脲很容易通过肼衍生物与磺酰氯在碱性氧化铝存在下在无溶剂条件下反应制备。磺酰氯与碳酸叔丁酯反应，然后水解提供相应的磺酰肼，其产率比先前报道的更高，时间更短。
• Studies on Antitumor Substances. X. Reactions of Thiosulfonates with Some Nucleophilic Compounds
  作者：SEIGORO HAYASHI、MITSURU FURUKAWA、YOKO FUJINO、HAYASHI MATSUKURA

  DOI：10.1248/cpb.17.954

  日期：——

  Reactivities of mono and difunctional thiosulfonates toward several nucleophilic compounds, such as thiols, amines and the related compounds, were examined. In the result, some chemical behaviors unexpected were found in addition to the reactivity anticipated. Namely, in the reaction with piperazine, aralkyl thiosulfonate afforded aralkyltrisulfide in about 20% yield, without any formation of sulfenamide. Moreover, aromatic thiosulfonate gave a comparable good yield of 1-phenyl-2-arylsulfonylhydrazine in the reaction with phenylhydrazine, in addition to the formation of phenylhydrazinium salt of aromatic sulfinic acid.

  对几种亲核化合物（如硫醇、胺及相关化合物）进行了一元和二元硫代磺酸盐的反应性研究。结果发现，除了预期的反应性外，还发现了一些意想不到的化学行为。具体而言，在与哌嗪的反应中，芳基烷基硫代磺酸盐以约20%的收率生成了芳基烷基三硫化物，并没有形成硫酰胺。此外，芳香硫代磺酸盐与苯基肼反应时，除了生成芳香亚磺酸的苯基肼盐外，还获得了可比较的1-苯基-2-芳基磺酰肼的良好收率。