异丙基肼盐酸盐 | 16726-41-3

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 异丙基肼盐酸盐
• 中文别名: 异丙肼盐酸盐；异丙基联胺盐酸盐；异丙基肼单盐酸盐
• 英文名称: isopropylhydrazine hydrochloride
• 英文别名: isopropylhydrazine monohydrochloride；propan-2-ylhydrazine hydrochloride；N-isopropylhydrazine hydrochloride；i-propylhydrazine hydrochloride；Hydron;propan-2-ylhydrazine;chloride；hydron;propan-2-ylhydrazine;chloride
• CAS: 16726-41-3
• 化学式: C₃H₁₀N₂*ClH
• mdl: MFCD01746887
• 分子量: 110.587
• InChiKey: ILULYDJFTJKQAP-UHFFFAOYSA-N

物化性质

• 熔点：
  115-118

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  39.7
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S45
• 危险类别码：
  R25
• 海关编码：
  2928000090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302+H312+H332,H315,H319,H335
• 储存条件：
  存放于惰性气体中，以避免接触空气和湿气（吸湿）。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Isopropylhydrazine, HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H301: Toxic if swallowed
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician

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Section 3. Composition/information on ingredients.
Ingredient name: Isopropylhydrazine, HCl
CAS number: 16726-41-3

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Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C3H10N2.ClH
Molecular weight: 110.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
UN Number: UN2811 Class: 6.1 Packing group: III
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (Isopropylhydrazine, HCl)

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

应用

异丙基肼盐酸盐可用作强效单胺氧化酶抑制剂，主要用于实验室研发过程和化工生产过程中。

制备

在惰性气体的保护下，通过盐酸肼与异丙醇反应制得异丙基肼盐酸盐。再用水合肼游离异丙基肼盐酸盐制得异丙基肼粗品，并通过蒸馏和精制获得纯净的异丙基肼。

用途

异丙基肼盐酸盐用作强效单胺氧化酶抑制剂。

反应信息

• 作为反应物：
  描述：

  异丙基肼盐酸盐 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 异丙基肼
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED 2,4,5,6,7,8-HEXAHYDRO-1,2,6-TRIAZA-AZULENE DERIVATIVES
  [FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE 2,4,5,6,7,8-HEXAHYDRO-1,2,6-TRIAZA-AZULÈNE SUBSTITUÉS

  摘要：

  本发明涉及制备式(I)和(II)的取代2,4,5,6,7,8-六氢-1,2,6-三氮杂环庚烯衍生物的方法，该衍生物对通过5-羟色胺受体活性介导的疾病状态具有治疗作用。

  公开号：

  WO2009058810A1
• 作为产物：
  描述：

  2-甲基-2-丙基2-异亚丙基肼羧酸酯 在 甲醇 、 sodium cyanoborohydride 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.17h， 生成 异丙基肼盐酸盐
  参考文献：
  名称：

  [EN] PROTEIN KINASE INHIBITORS
  [FR] INHIBITEURS DE PROTÉINE KINASES

  摘要：

  本发明涉及一种新型的蛋白激酶抑制剂家族。具体而言，本发明涉及Tec和Src蛋白激酶家族成员的抑制剂。

  公开号：

  WO2013177668A1
• 作为试剂：
  描述：

  N-(2-methylidenepentylideneamino)propan-2-amine 在 硫酸 、 异丙基肼盐酸盐 作用下， 生成 2-甲基-2-戊烯醛
  参考文献：
  名称：

  由不饱和醛形成结构异常的吡唑啉的原因

  摘要：

  DOI：

  10.1007/bf00480733

文献信息

• Imidazoline derivatives as alpha-1A adrenoceptor ligands
  申请人：Bigham Eric Cleveland

  公开号：US06884801B1

  公开（公告）日：2005-04-26

  Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.

  化合物的化学式（I）或其药用可接受的盐或溶剂的复合物已被披露。这些化合物在治疗Alpha-1A介导的疾病或症状，如尿失禁方面是有用的。
• [EN] 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS<br/>[FR] 1H-PYRAZOLO [4,3-B] PYRIDINES EN TANT QU'INHIBITEURS DE PDE1
  申请人：H LUNDBECK AS

  公开号：WO2018007249A1

  公开（公告）日：2018-01-11

  The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了式(I)的1H-吡唑并[4,3-b]吡啶-7-胺作为PDE1抑制剂，并将其用作药物，特别用于治疗神经退行性疾病和精神疾病。
• MACROCYCLES AS PDE1 INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20190185489A1

  公开（公告）日：2019-06-20

  The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了式(I)的大环化合物作为PDE1抑制剂，并将其用作药物，特别用于治疗神经退行性疾病和精神疾病。
• 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20190194189A1

  公开（公告）日：2019-06-27

  The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了式(I)的1H-吡唑并[4,3-b]吡啶类化合物作为PDE1抑制剂，并将其用作药物，特别用于治疗神经退行性疾病和精神疾病。
• 稠合四环类化合物及其在药物中的应用
  申请人：广东东阳光药业有限公司

  公开号：CN113444102A

  公开（公告）日：2021-09-28

  本发明涉及一种稠合四环类化合物及其在药物中的应用，尤其是作为用于治疗和/或预防乙型肝炎的药物的应用。具体地说，本发明涉及通式(I)所示化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药，以及它们作为药物的用途，尤其是作为用于治疗和/或预防乙型肝炎的药物的用途。其中各变量如说明书所定义。