2-(chloromethyl)-7H-furo<3.2-g><1>benzopyran-7-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-(chloromethyl)-7H-furo<3.2-g><1>benzopyran-7-one
• 英文别名: 2-(chloromethyl)-7H-furo[3,2-g]chromen-7-one；2-(Chloromethyl)furo[3,2-g]chromen-7-one
• 化学式: C₁₂H₇ClO₃
• 分子量: 234.639
• InChiKey: QPXSLOMLQRRQPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(chloromethyl)-7H-furo<3.2-g><1>benzopyran-7-one 、 正丁醇 以80%的产率得到2-(butoxymethyl)-7H-furo[3,2-g]chromen-7-one
  参考文献：
  名称：

  Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure–activity relationship study

  摘要：

  Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of la were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 mu g/mL) than 1a (MIC = 6.25 mu g/mL), and is even potent than the positive control metronidazole (MIC = 0.50 mu g/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of la have also led to an outline of structure-activity relationship. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.045
• 作为产物：
  描述：

  补骨脂素 、 二氯甲基醚 在 溶剂黄146 作用下， 反应 36.0h， 以68%的产率得到2-(chloromethyl)-7H-furo<3.2-g><1>benzopyran-7-one
  参考文献：
  名称：

  Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure–activity relationship study

  摘要：

  Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of la were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 mu g/mL) than 1a (MIC = 6.25 mu g/mL), and is even potent than the positive control metronidazole (MIC = 0.50 mu g/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of la have also led to an outline of structure-activity relationship. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.045

文献信息

• Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain
  作者：S. Manfredini、P. G. Baraldi、R. Bazzanini、M. Guarneri、D. Simoni、J. Balzarini、E. De Clercq

  DOI：10.1021/jm00041a019

  日期：1994.7

  different physicochemical properties, were designed in order to study this hypothesis. Moreover, to further investigate the modification of the alkenyl side chain, (E)- and (Z)-[2-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)propenyl]-7H-furo[3,2- g][1]benzopyran-7-one (11a,b) were synthesized, the latter compounds being the combination of two units, namely, the 3(2H)-furanone ring system endowed with potent

  作为先前对在烷基侧链中带有氨基甲酸酯部分的geeparvarin类似物的合成和抗肿瘤活性的研究的继续，一系列N取代的[（E）-3-（4,5-dihydro-5,5-dimethyl合成并测试了-4-氧代-2-呋喃基-2-（呋喃基）-2-丁烯基]氨基甲酸酯（15a-f），以研究烷基和苯基衍生物之间发现的细胞抑制活性明显差异的原因。为了研究这一假设，设计了一系列具有不同理化性质的化合物。此外，为了进一步研究烯基侧链的修饰，（E）-和（Z）-[2-（4,5-二氢-5,5-二甲基-4-氧代-2-呋喃基）丙烯基] -7H合成了-呋喃[3,2- g] [1]苯并吡喃-7-一（11a，b），后一种化合物是两个单元的组合，即 具有强大烷基化特性的3（2H）-呋喃酮环系统和与DNA结合的呋喃香豆素部分，可产生潜在的靶向DNA的烷基化剂。测试了化合物对鼠类（L1210）和人（Molt / 4，CEM或MT-4