N-(3-羟基苯基)-2-甲基丙酰胺 | 55791-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-羟基苯基)-2-甲基丙酰胺
• 英文名称: N-(3-hydroxyphenyl)isobutyramide
• 英文别名: N-(3-hydroxyphenyl)-2-methylpropanamide；3'-hydroxy-2-methylpropionanilide；3'-Hydroxy-2-methyl-propionanilid；3'-Hydroxyisobutyranilid
• CAS: 55791-88-3
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD01695805
• 分子量: 179.219
• InChiKey: RGSXNBKIMXWTIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-羟基苯基)-2-甲基丙酰胺 、 异氰酸甲酯 以 乙酸乙酯 为溶剂， 生成 2-methyl-3'-(methylcarbamoyloxy)propionanilide
  参考文献：
  名称：

  Meta-bifunctional benzenes and herbicidal compositions

  摘要：

  通式##EQU1##中的元双功能化合物，其中A选自##EQU2##这些化合物具有除草活性。

  公开号：

  US03979202A1
• 作为产物：
  描述：

  3-异丁酰胺基苯基硼酸 在 copper(ll) sulfate pentahydrate 、 鞣花酸 作用下， 以 甲醇 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 8.0h， 以72%的产率得到N-(3-羟基苯基)-2-甲基丙酰胺
  参考文献：
  名称：

  Oxidative hydroxylation of arylboronic acids to phenols catalyzed by copper nanoparticles ellagic acid composite

  摘要：

  Copper nanoparticles (Cu NPs) were prepared by in situ reduction of CuSO4 center dot 5H(2)O using ellagic acid (EA) as the reducing agent as well as stabilizer and its catalytic activity is tested in the oxidative hydroxylation of phenylboronic acids to phenol without any added base or ligand. The synthesized Cu NPs-EA composite was characterized by UV-Vis., FT-IR, powder XRD and HRTEM analyses. The average particle size of Cu NPs is found to be in the range of 20-25 nm as evident from HRTEM and copper content is estimated to be 3.18 wt%. EA acts both as a reducing agent as well as a stabilizer for the in situ formation of Cu NPs. A small portion of Cu NPs is also found to undergo aerobic oxidation to give Cu2O NPs which does not take part in the reactions. A series of arylboronic acids are converted to the corresponding phenols in high yields at short reaction time under milder reaction conditions. It is also observed that Cu NPs-EA composite can be reused at least four times with a significant decrease in the yield. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.09.016

文献信息

• 10a-Azalide compound crosslinked at 10a- and 12-positions
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：US08293715B2

  公开（公告）日：2012-10-23

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，对于甚至包括流感嗜血杆菌或红霉素耐药细菌（例如耐药性肺炎球菌和链球菌）都具有有效性。
• 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS
  申请人：Sugimoto Tomohiro

  公开号：US20110237784A1

  公开（公告）日：2011-09-29

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，并且对于Hemophilus influenzae，或者对红霉素产生耐药性的细菌（例如耐药性肺炎球菌和链球菌）具有有效性。
• 10A-AZALIDE COMPOUND CROSSLINKED AT POSITION-10A AND POSITION-12
  申请人：Taisho Pharmaceutical Co. Ltd.

  公开号：EP2177526A1

  公开（公告）日：2010-04-21

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种在 10a- 位和 12- 位交联的新型 10a- 叠氮酰胺化合物，由下式表示，甚至对流感嗜血杆菌或红霉素耐药菌（如耐药肺炎球菌和链球菌）也有效。
• US3979202A
  申请人：——

  公开号：US3979202A

  公开（公告）日：1976-09-07
• US8293715B2
  申请人：——

  公开号：US8293715B2

  公开（公告）日：2012-10-23