4-(苯氧基甲基)苯酚 | 55846-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(苯氧基甲基)苯酚
• 英文名称: 4-Hydroxy-α-phenoxy-toluol
• 英文别名: Phenyl-(4-hydroxy-benzyl)-aether；4-Phenoxymethyl-phenol；4-phenoxymethylphenol；4-(Phenoxymethyl)phenol
• CAS: 55846-07-6
• 化学式: C₁₃H₁₂O₂
• 分子量: 200.237
• InChiKey: PSBWSIWOVNCTKX-UHFFFAOYSA-N

物化性质

• 熔点：
  155-158 °C
• 沸点：
  352.4±17.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(苯氧基甲基)苯酚 、 异氰酸甲酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以92%的产率得到[4-(phenoxymethyl)phenyl] N-methylcarbamate
  参考文献：
  名称：

  Protection des phenols par le groupement azidomethylene application a la synthese de phenols instables

  摘要：

  DOI：

  10.1016/s0040-4020(01)89794-5
• 作为产物：
  描述：

  1-(azidomethoxy)-4-(phenoxymethyl)benzene 在 tin(ll) chloride 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以88%的产率得到4-(苯氧基甲基)苯酚
  参考文献：
  名称：

  Protection des phenols par le groupement azidomethylene application a la synthese de phenols instables

  摘要：

  DOI：

  10.1016/s0040-4020(01)89794-5

文献信息

• AMINOETHYLATION PROCESS HAVING IMPROVED YIELD OF ARYLOXYALKYLENE AMINE COMPOUNDS AND REDUCED UREA BY-PRODUCTS
  申请人：McDougall Patrick J.

  公开号：US20140073814A1

  公开（公告）日：2014-03-13

  Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R 3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R 4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

  揭示了一种通过氨基乙基化反应制备芳基氧基烷胺化合物的过程，包括：a)在碱性催化剂存在下，将芳香羟基化合物与式II的2-噁唑烷酮化合物反应，形成中间反应产物；其中R3选自氢或1至6个碳原子的较低烷基，R4选自氢、一元或分支链烷基（含1至6个碳原子）、苯基、烷基芳基或芳基烷基；b)将步骤a）中间产物与聚烷基聚胺反应。
• Phenoxypropionic acid derivatives
  申请人：Merck Patent Gesellschaft mit beschrankter Haftung

  公开号：US03968143A1

  公开（公告）日：1976-07-06

  Phenoxypropionic acid derivatives of the formula ##SPC1## Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2## With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.

  苯氧丙酸衍生物的化学式为##SPC1##其中Q为H或卤素原子，R为H或CH.sub.3，Z为--OH，--O-烷基（1-4个碳原子），1-甲基-4-哌啶氧或--NHCH.sub.2 CH.sub.2 OH，以及其生理上可接受的盐；具有降低胆固醇和甘油三酯血清水平的活性，可以通过苯酚##SPC2##与化合物X-CR(CH.sub.3)--CO--Z（其中X为Cl、Br、I或自由或酯化的OH基团，Q、R和Z具有上述给定的值）反应制备。
• Process for producing organic compound epoxy resin composition, cured article obtained from the epoxy resin, and semiconductor device obtained with epoxy resin
  申请人：——

  公开号：US20040260039A1

  公开（公告）日：2004-12-23

  There are disclosed a process for producing an organic compound in the presence of a particular substituted triarylphosphine compound, particularly, a process for producing an oxyalkylene derivative at a high yield using the above compound which is very active and easy to handle, by reacting an organic epoxy compound with a carboxylic acid ester, a carboxylic acid anhydride, a sulfonic acid ester or a carbonic acid ester, and an epoxy resin composition using a particular substituted triarylphosphine compound as a curing accelerator, a cured material of the composition and a semiconductor device using the composition.

  本文披露了一种在特定取代三芳基膦化合物存在下生产有机化合物的工艺，特别是一种使用上述化合物作为催化剂，通过将有机环氧化合物与羧酸酯、羧酸酐、磺酸酯或碳酸酯反应，以及使用特定取代三芳基膦化合物作为固化促进剂的环氧树脂组合物的工艺，从而高产地生产氧代烷基衍生物，还包括该组合物的固化材料和使用该组合物的半导体器件。
• Aryl and heteroaryl ethers as agents for the treatment of hypersensitive
  申请人：Rorer Pharmaceutical Corporation

  公开号：US04839369A1

  公开（公告）日：1989-06-13

  Aryl and Heteroaryl Ethers are used for their anti-inflammatory and anti-allergic properties.

  芳基和杂芳基醚因其抗炎和抗过敏特性而被使用。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。