ATyr

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ATyr
• 英文别名: N-acryloyltyrosine；3-(4-Hydroxyphenyl)-2-(prop-2-enamido)propanoic acid；3-(4-hydroxyphenyl)-2-(prop-2-enoylamino)propanoic acid
• 化学式: C₁₂H₁₃NO₄
• mdl: MFCD09947797
• 分子量: 235.24
• InChiKey: ISPFRDAWONQRSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  DL-酪氨酸 、 丙烯酰氯 生成 ATyr
  参考文献：
  名称：

  Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media

  摘要：

  The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by (1)H NMR (1)H NMR for methyl-beta-D-galactopyranoside (M beta Gal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with M beta Gal in aqueous media whereas CH-pi interaction was relatively important. (1)H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the beta-anomers than with the alpha-anomers presumably because of the triple CH-pi interactions of the three axial protons in the beta-anomers. In the interaction of pATrp with M beta Gal, M beta Gal interacted with two or more Trp residues because Trp residues were localized on the polymer chain. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2009.10.070

文献信息

• THERMO-RESPONSIVE HYDROGEL COMPOSITIONS
  申请人：KANG-MIELER Jennifer J.

  公开号：US20120231072A1

  公开（公告）日：2012-09-13

  A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having an amino acid side chain. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

  一种热响应性水凝胶，包括具有氨基酸侧链的生物相容性单体和/或聚合物。该水凝胶在生理温度下具有热响应性，可以包含、结合或封装治疗剂，如药物组合物、生物分子和/或纳米颗粒。该水凝胶在传递治疗剂方面很有用。该水凝胶处于第一物理化学状态以用于哺乳动物。该水凝胶在哺乳动物的生理温度下具有热响应性，并转变为比第一物理化学状态更固体的第二物理化学状态。在第二物理化学状态下，热响应性水凝胶释放治疗剂。
• New polymer materials for contact lens applications
  申请人：CIS Pharma AG

  公开号：US20200283560A1

  公开（公告）日：2020-09-10

  The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

  本发明涉及由聚合混合物制成的共聚物，所述聚合混合物包括（a）一种或多种可聚合单体，该单体被表征为至少具有一个乙烯基团且不含氨基酸残基，（b）一种或多种未功能化的侧链连接的氨基酸，（c）一种或多种功能化的侧链连接的氨基酸，（d）自由基引发剂，以及可选地，（e）链转移剂。还涉及包含相同单体的嵌段共聚物。该发明还涵盖涂有或包含后述共聚物和嵌段共聚物的硅水凝胶隐形眼镜，以及将这些共聚物和嵌段共聚物引入硅水凝胶隐形眼镜的方法。
• AFLATOXIN TEMPLATES, MOLECULARLY IMPRINTED POLYMERS, AND METHODS OF MAKING AND USING THE SAME
  申请人：Alltech, Inc.

  公开号：US20160221983A1

  公开（公告）日：2016-08-04

  Molecularly imprinted polymers (MIPs) are materials exhibiting molecular recognition of a target molecule. MIPs are synthesized in the presence of an aflatoxin template, a mimic to the targeted molecule, used as an imprint that is further washed away with suitable solvent after completion of the polymerization process, leaving a cavity in the polymer of the same stereochemistry, functionality and morphology to the template. When the MIP encounters an aflatoxin, the molecule is bound in the cavity with a receptor-like affinity.

  分子印迹聚合物（MIPs）是一种表现出对目标分子的分子识别的材料。MIPs在黄曲霉毒素模板的存在下合成，该模板是目标分子的模拟物，用作印迹，聚合过程完成后，用适当的溶剂清洗掉，留下聚合物中具有相同立体化学、功能和形态的空腔。当MIP遇到黄曲霉毒素时，分子会以受体般的亲和力结合在空腔中。
• DENTAL PHOTOCURABLE COMPOSITION CONTAINING HIGH SOLUBLE PHOTOACID GENERATOR
  申请人：Shofu Inc.

  公开号：EP3888615A1

  公开（公告）日：2021-10-06

  [Problem] To provide a dental photocurable composition which can exhibit excellent mechanical characteristics even after returning from a low temperature to room temperature. [Solution] To provide a dental photocurable composition, comprising (A) polymerizable monomer, (B) photosensitizer, (C) photoacid generator and (D) photopolymerization accelerator and the (C) photoacid generator may include only (C-1) iodonium salt-based compound of an anion having log S of -4 or less.

  问题 提供一种牙科光固化组合物，该组合物在从低温返回室温后仍能表现出优异的机械特性。 [解决方案］ 提供一种牙科光固化组合物，该组合物由(A)可聚合单体、(B)光敏剂、(C)光酸发生器和(D)光聚合加速剂组成。
• DENTAL PHOTOCURABLE COMPOSITION EXCELLENT IN COLOR TONE SELECTIVITY
  申请人：Shofu Inc.

  公开号：EP3888616A1

  公开（公告）日：2021-10-06

  To provide a dental photocurable composition having sufficient mechanical property and being excellent in color tone selectivity because of having a small color difference between before curing and after curing. [Solution] To provide a dental photocurable composition, comprising (A) polymerizable monomer, (B) photosensitizer, (C) photoacid generator, (D) photopolymerization accelerator and (E) filler, wherein, the dental photocurable composition comprises (B-1) α-diketone compound as the (B) photosensitizer, and the dental photocurable composition comprises, with respect to 100 parts by mass of the (A) polymerizable monomer, 0.15 parts by mass or less of the (B-1) α-diketone compound, 0.5 parts by mass or more of the (C) photoacid generator, and 100 parts by mass or more of the (E) filler.

  提供一种牙科光固化组合物，该组合物具有足够的机械性能，并且由于固化前和固化后的色差很小，因此具有极佳的色调选择性。 [解决方案］ 提供一种牙科光固化组合物，包括 (A) 可聚合单体、(B) 光敏剂、(C) 光酸发生器、(D) 光聚合促进剂和 (E) 填料，其中，牙科光固化组合物包括作为 (B) 光敏剂的 (B-1) α-二酮化合物，并且牙科光固化组合物包括，相对于 100 份（质量）的 (A) 可聚合单体，0.15份（质量份）或更少的(B-1)α-二酮化合物、0.5份（质量份）或更多的(C)光酸发生剂以及100份（质量份）或更多的(E)填料。