3-(cyclopropylmethoxy)-17-methyl-Morphinan

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-(cyclopropylmethoxy)-17-methyl-Morphinan
• 英文别名: 3-Cyclopropylmethoxy-17-methylmorphinan；(1R,9R,10R)-4-(cyclopropylmethoxy)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
• 化学式: C₂₁H₂₉NO
• 分子量: 311.467
• InChiKey: BJICDAOXUAEHPI-CEWLAPEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dextromethorphan hydrobromide 在 氢溴酸 、 sodium hydride 作用下， 生成 3-(cyclopropylmethoxy)-17-methyl-Morphinan
  参考文献：
  名称：

  Anticonvulsant effects of new morphinan derivatives

  摘要：

  We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5. 6. and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00262-1

文献信息

• NEUROPROTECTIVE PROPERTIES OF DEXTROROTATORY MORPHINANS
  申请人：KIM Hyoung-Chun

  公开号：US20050256147A1

  公开（公告）日：2005-11-17

  The present application discloses a pharmaceutical composition for treating Parkinson's disease and psychotropic intoxication/abusive potential, which contains a morphinan compound.

  本申请公开了一种治疗帕金森病和精神药物中毒/滥用潜力的药物组合物，其中包含一种吗啡类化合物。
• 右旋性モルヒナンの神経保護特性
  申请人：グリーン・クロス・コーポレイション

  公开号：JP4805256B2

  公开（公告）日：2007-12-20
• TREATMENT OF ANTIFOLATE NEUROTOXICITY
  申请人：Syntrix Biosystems, Inc.

  公开号：US20140171436A1

  公开（公告）日：2014-06-19

  The present invention is a method of treating antifolate neurotoxicity in a mammal suffering from or at risk of developing antifolate neurotoxicity, which comprises administering to the mammal a therapeutically effective amount of an NMDA antagonist, or a pharmaceutically acceptable salt thereof.
• US7691874B2
  申请人：——

  公开号：US7691874B2

  公开（公告）日：2010-04-06
• [EN] NEUROPROTECTIVE PROPERTIES OF DEXTROROTATORY MORPHINANS<br/>[FR] PROPRIETES NEUROPROTECTRICES DE MORPHINANES DE DEXTROROTATION
  申请人：KIM HYOUNG-CHUN

  公开号：WO2005110412A1

  公开（公告）日：2005-11-24

  The present application discloses a pharmaceutical composition for treating Parkinson’s disease and psychotropic intoxication/abusive potential, which contains a morphinan compound.