特普 | 107-49-3

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 中文名称: 特普
• 中文别名: 四乙基焦磷酸酯；焦磷酸四乙酯；双-O,O-二乙基磷酸酐；死虫四磷
• 英文名称: Tetraethyl pyrophosphate
• 英文别名: diethoxyphosphoryl diethyl phosphate
• CAS: 107-49-3
• 化学式: C₈H₂₀O₇P₂
• 分子量: 290.19
• InChiKey: IDCBOTIENDVCBQ-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：

  避免与强碱、水或潮湿空气接触。

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

代谢

血浆和肝脏酯酶负责将有机磷化合物水解成相应的磷酸和磷onic酸。然而，细胞色素P450负责将含有磷硫（硫代）键的无效磷硫代硫酸盐转化为带有磷氧键的磷酸盐，从而使其活化。/抗胆碱酯酶剂/

Plasma and liver esterases are responsible for hydrolysis /of organophosphorus compounds/ to the corresponding phosphoric and phosphonic acids. However, cytochrome P450's are responsible for converting the inactive phosphorothioates containing a phosphorous sulfur (thiono) bond to phosphorates with an phosphorus-oxygen bond, resulting in their activation. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

代谢

有机磷抗胆碱酯酶剂在体内被一组称为A-酯酶或对氧磷酶的酶水解。这些酶存在于血浆和肝脏中，能够水解大量的有机磷化合物...通过切断磷酯键、酐键、P-F键或P-CN键。/抗胆碱酯酶剂/

The organophosphorus anticholinesterase agents are hydrolyzed in the body by a group of enzymes known as A-esterases or paraoxonases. These enzymes are found in the plasma and liver and hydrolyze a large number of organophosphorus compounds... by cleaving the phosphoester, anhydride, P-F, or P-CN bonds. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

这种物质可以通过吸入、皮肤接触和摄入被身体吸收。

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，皮肤吸收，吞食，皮肤和/或眼睛接触

inhalation, skin absorption, ingestion, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼痛，视力模糊，流泪（眼泪排出）；流鼻涕（排出稀薄的鼻粘液）；头痛，胸闷，发绀；厌食，恶心，呕吐，腹泻；乏力（虚弱，疲惫），抽搐，瘫痪，潮式呼吸，惊厥；低血压，心脏不规则；出汗

Eye pain, blurred vision, lacrimation (discharge of tears); rhinorrhea (discharge of thin nasal mucus); headache, chest tightness, cyanosis; anorexia, nausea, vomiting, diarrhea; lassitude (weakness, exhaustion), twitching, paralysis, Cheyne-Stokes respiration, convulsions; low blood pressure, cardiac irreg; sweating

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 吸入症状

晕眩。瞳孔收缩，肌肉痉挛，过度流涎。出汗。呼吸困难。咳嗽。无力。腹部绞痛。腹泻。恶心。呕吐。不协调。抽搐。昏迷。

Dizziness. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Laboured breathing. Cough. Weakness. Abdominal cramps. Diarrhoea. Nausea. Vomiting. Incoordination. Convulsions. Unconsciousness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

容易吸收！红色。疼痛。进一步见吸入。

EASILY ABSORBED! Redness. Pain. Further see Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

它通过皮肤被迅速吸收...

It is absorbed quickly through the skin ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

该物质可以通过吸入、经皮肤、经口摄入和经眼睛吸收进入人体。

The substance can be absorbed into the body by inhalation, through the skin, by ingestion and through the eyes.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

...皮肤吸收在环境温度较高时会更强烈，并且如果存在皮炎，吸收量还会增加。

... Skin absorption is... greater at higher ambient temperatures, and is increased by the presence of dermatitis.

来源:Hazardous Substances Data Bank (HSDB)

制备方法与用途

制备方法：用于农用杀蚜和杀螨。

用途简介： 暂无详细信息。

用途： 用于农用杀蚜和杀螨。

反应信息

• 作为反应物：
  描述：

  特普 在 tin(ll) chloride 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到complex of tetraethyl pyrophosphate with tin dichloride
  参考文献：
  名称：

  Muratova, A. A.; Sobanova, O. B.; Yarkova, E. G., Journal of general chemistry of the USSR, 1980, vol. 50, # 2, p. 222 - 226

  摘要：

  DOI：
• 作为产物：
  描述：

  硫代焦磷酸四乙酯 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到特普
  参考文献：
  名称：

  A General Method for the Conversion of Thiophosphoryl and Selenophosphoryl Groups into Phosphoryl Groups by Ozone Oxidation

  摘要：

  DOI：

  10.1055/s-1983-30407
• 作为试剂：
  描述：

  乙烯酮 、 乙酰乙酸乙酯 在 特普 作用下， 生成 3-甲基丁-3-烯酸乙酯
  参考文献：
  名称：

  Preparation of beta-lactones

  摘要：

  公开号：

  US02450118A1

文献信息

• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• CARBALDEHYDE OXIMES AS BUTYRYLCHOLINESTERASE REACTIVATORS
  申请人：Etat Français représenté par la Direction Centrale Du Service de Santé des Armées

  公开号：EP3945092A1

  公开（公告）日：2022-02-02

  The present invention relates to compounds for their use in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of the intoxication with at least one organophosphorus nerve agent. The invention also relates to pharmaceutical compositions and kits comprising said compounds, and compounds per se.

  本发明涉及化合物，用于重新激活丁酰胆碱酯酶。这些化合物在治疗或预防至少一种有机磷神经毒剂中毒方面是有用的。该发明还涉及包含所述化合物的药物组合物和试剂盒，以及化合物本身。
• [EN] MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO<br/>[FR] MOLÉCULES PRÉSENTANT UNE UTILITÉ EN TANT QUE PESTICIDE, ET LEURS INTERMÉDIAIRES, COMPOSITIONS ET PROCÉDÉS
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2017040194A1

  公开（公告）日：2017-03-09

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions aga inst such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫有用的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的杀虫剂组合物，以及使用这种杀虫剂组合物对抗这些害虫的过程。这些杀虫剂组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下化学式（“化学式一”）的分子。
• MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20170210723A1

  公开（公告）日：2017-07-27

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的组合物，以及使用这种分子和组合物对抗这些害虫的过程。这些分子和组合物可以用作杀螨剂、杀虫剂、杀螨剂、杀软体动物剂和杀线虫剂。本文件披露了具有以下式（“式一”）的分子。
• The Reactions of Dialkyl Phosphites and Phosphine Oxides with Iodosylbenzene
  作者：Sławomir Makowiec、Janusz Rachon

  DOI：10.1080/10426500210674

  日期：2002.4.1

  The reaction of iodosylbenzene with >P(O)H type of acids (dialkyl phosphites, secondary phosphine oxides) was studied. The acids of >P(O)H type add to iodosylbenzene to yield intermediate 6 which in the aprotic solvents yields oxidation products, it means >P(O)OH acids and/or anhydride of >P(O)OP(O)< type. On the other hand if the reaction is performed in alcohol as a solvent in the presence of sodium

  研究了碘代苯与 >P(O)H 型酸（亚磷酸二烷基酯、氧化膦）的反应。>P(O)H 型酸加到碘代基苯中得到中间体 6，在非质子溶剂中产生氧化产物，这意味着 >P(O)OH 酸和/或 >P(O)OP(O)< 的酸酐类型。另一方面，如果反应在醇钠存在下以醇为溶剂进行，> P(O)OR 酯是主要产物。