(E)-hydroxyimino-phenyl-acetic acid | 25327-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-hydroxyimino-phenyl-acetic acid
• 英文别名: anti-Phenylglyoxylsaeure；anti-α-Oximino-phenylessigsaeure；(E)-Hydroxyimino-phenyl-essigsaeure；hoeherschmelzende α-Isonitroso-phenylessigsaeure；Hoeherschmelzende α-Oximino-phenylessigsaeure；α-oximinophenylacetic acid；Phenylglyoxylsaeure-β-oxim；E-Hydroxyimino-phenylacetic acid；(2E)-2-hydroxyimino-2-phenylacetic acid
• CAS: 25327-35-9
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: NRNOFFFWOYJUCR-VQHVLOKHSA-N

物化性质

• 沸点：
  378.3±25.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-hydroxyimino-phenyl-acetic acid 在 硫酸 作用下， 以 聚合甲醛 为溶剂， 生成 苯甲酰甲酸
  参考文献：
  名称：

  Process for preparing .alpha.-ketocarboxylic acids

  摘要：

  一种制备α-酮羧酸的新工艺，包括将氧化亚氮卤化物与氰化物离子反应形成氧化亚氮腈，然后将氧化亚氮腈与氢氧根离子反应形成氧化亚氮酸，最后通过水解得到α-酮酸。

  公开号：

  US04334087A1
• 作为产物：
  描述：

  phenylglyoxylic acid oxime 以 水 为溶剂， 生成 (E)-hydroxyimino-phenyl-acetic acid
  参考文献：
  名称：

  THE CONVERSION OF α-KETO ACIDS AND OF α-KETO ACID OXIMES TO NITRILES IN AQUEOUS SOLUTION

  摘要：

  在水溶液中，α-羟肟酸（抗HO— —COOH）转化为腈是一种普遍的反应。在水溶液中，α-酮酸在羟胺存在下以极高的产率转化为腈。α-羟肟酸的氧化产生羟胺酸。

  DOI：

  10.1139/v61-169

文献信息

• Use of phenethyl acrylamides, novel phenethyl acrylamides, method for the production thereof and agents containing the same
  申请人：——

  公开号：US20030191190A1

  公开（公告）日：2003-10-09

  The invention relates to the use of phenethyl acrylamides of formula I for controlling phytopathogenic fungi, wherein the substituents of said phenethyl acrylamides have the following significations: X signifies halogen, alkyl, halogenalkyl, alkoxy halogenalkoxy and —O—C(R a , R b )—C≡C—R 6 ; R a , R b and R c have the signification given in the description; m, n independently signify 1 to 4, the radicals X or Y being potentially different if m or n is higher than 1; Y signifies halogen, nitro, cyano, alkyl, CF 3 , alkoxy and phenyl; R 1 , R 2 independently signify hydrogen, halogen, alkyl, alkoxy, halogenalkoxy and CF 3 ; R 3 , R 4 , R 5 , and R 6 independently signify hydrogen, alkyl and alkoxy, or R 3 and R 4 together form a cyclopropyl ring, whereby the C—R 5 and C—R 6 bonds can be in position E or Z in relation to each other. The invention also relates to novel phenethyl acrylamides, a method for the productio thereof, and agents containing the same.

  该发明涉及使用式I的苯乙基丙烯酰胺来控制植物病原真菌，其中所述苯乙基丙烯酰胺的取代基具有以下含义：X表示卤素、烷基、卤代烷基、烷氧基、卤代烷氧基和—O—C(Ra，Rb)—C≡C—R6；Ra，Rb和Rc在描述中给出了相应的含义；m，n独立地表示1到4，如果m或n大于1，则基团X或Y可能不同；Y表示卤素、硝基、氰基、烷基、三氟甲基、烷氧基和苯基；R1，R2独立地表示氢、卤素、烷基、烷氧基、卤代烷氧基和三氟甲基；R3，R4，R5和R6独立地表示氢、烷基和烷氧基，或者R3和R4一起形成环丙基环，其中C—R5和C—R6键可以在彼此之间的位置E或Z。该发明还涉及新型苯乙基丙烯酰胺、其生产方法以及含有该化合物的制剂。
• Preparation of 2-aryl-2-hydroxyiminoacetic acids (syn isomers)
  申请人：Glaxo Laboratories Limited

  公开号：US03959314A1

  公开（公告）日：1976-05-25

  2-Aryl-2-hydroxyiminoacetic acids rich in the syn isomer are prepared by reaction of an arylglyoxylic acid with hydroxylamine in an aqueous reaction medium, e.g. water, in the presence of a source of magnesium, calcium or zinc ions, e.g. magnesium hydroxide. The acids so obtained are of value as synthetic intermediates in the preparation of penicillin and cephalosporin antibiotics containing syn-2-aryl-2-hydroxyiminoacetamido side chains.

  富含syn异构体的2-芳基-2-羟基亚胺基乙酸可以通过在水或其他水溶液反应介质中，例如水中，将芳基甘氨酸与羟胺反应，并在镁、钙或锌离子源（例如氢氧化镁）的存在下制备。所得到的这些酸在合成含有syn-2-芳基-2-羟基亚胺基乙酰胺侧链的青霉素和头孢菌素类抗生素的合成中是有价值的中间体。
• Z-substituted acrylamides, methods for production thereof and agents comprising the same
  申请人：Grammenos Wassilios

  公开号：US20050107619A1

  公开（公告）日：2005-05-19

  Z-substituted acrylamides of formula (I), where the substituents have the following meanings: X=H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, with X in the 3- or 4-position, n=1 or 2, where X can be different if n=2, R 1 =alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, aziridine and oxirane and R 2 =H, alkyl, haloalkyl, allyl, propargyl or CH 2 C≡C-alkyl. Methods for production thereof, agents comprising the above and the use thereof for the treatment of plant-pathogenic fungal pests.

  式(I)的Z-取代丙烯酰胺，其中取代基具有以下含义：X=氢，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，其中X在3-或4-位，n=1或2，如果n=2，X可以不同，R1=烷基，卤代烷基，环烷基，烷氧基，卤代烷氧基，环氧丙烷和氮杂环丙烷，R2=氢，烷基，卤代烷基，烯丙基，炔丙基或CH2C≡C-烷基。生产方法，包含上述化合物的制剂以及用于治疗植物病原真菌害虫的用途。
• Phenethylacrylamide, methods for the production thereof and agents containing the same
  申请人：Grammenos Wassilios

  公开号：US20050181948A1

  公开（公告）日：2005-08-18

  The present invention relates to novel phenethylacrylamides of the formula I in which the substituents R 1 , R 2 , R 3 and R 4 have the following meanings: R 1 is hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 3 -C 8 -cycloalkyl, C 1 -C 4 -haloalkoxy or C 1 -C 4 -haloalkyl; R 2 is hydrogen, halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 3 -C 10 -cycloalkyl, C 1 -C 4 -haloalkoxy or C 1 -C 4 -haloalkyl; R 3 is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, propargyl, C 3 -C 4 -alkenyl or a radical of the formula —H 2 C—C≡C—C(R a , R a )—R c , wherein R a , R b independently of one another are hydrogen or methyl and R c is hydrogen or C 1 -C 4 -alkyl; R 4 is methyl or C 1 -haloalkyl; and Het is a 5- or 6-membered heteroaromatic ring, to processes for their preparation, and to the use of phenethylacrylamides of the formula I for controlling phytopathogenic harmful fungi.

  本发明涉及公式I的新型苯乙基丙烯酰胺，其中取代基R1、R2、R3和R4的含义如下：R1为氢、卤素、C1-C4烷基、C1-C4烷氧基、C3-C8环烷基、C1-C4卤代烷氧基或C1-C4卤代烷基；R2为氢、卤素、C1-C4烷基、C1-C4烷氧基、C3-C10环烷基、C1-C4卤代烷氧基或C1-C4卤代烷基；R3为C1-C4烷基、C1-C4卤代烷基、丙炔基、C3-C4烯基或式—H2C—C≡C—C(Ra, Ra)—Rc的基团，其中Ra、Rb各自独立地为氢或甲基，Rc为氢或C1-C4烷基；R4为甲基或C1卤代烷基；Het为5-或6-成员的杂芳环，本发明还涉及制备这些苯乙基丙烯酰胺的过程，以及利用公式I的苯乙基丙烯酰胺控制植物病原真菌的用途。
• Immunosuppressive effects of pteridine derivatives
  申请人：Waer Jozef Albert Mark

  公开号：US20060287314A1

  公开（公告）日：2006-12-21

  This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.

  本发明涉及一组三取代和四取代喋啉衍生物，其药学上可接受的盐、N-氧化物、溶剂合物、二氢和四氢衍生物和对映体，具有意外的理想药理特性，特别是高度活性的免疫抑制剂，并因此在移植排斥和/或治疗某些炎症性疾病方面有用。这些化合物还有助于预防或治疗心血管疾病、过敏症、中枢神经系统疾病和细胞增殖性疾病。