Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
Benzisoxazole和azabenzisoxazole化合物可作为代谢型谷
氨酸受体亚型4(mGluR4)的变构增强剂/正向变构调节剂,并且这些化合物有用。制备这些化合物的合成方法;包含这些化合物的药物组合物;以及使用这些化合物的方法,例如用于治疗神经系统和精神疾病或与谷
氨酸功能失调相关的其他疾病状态。