4-(乙酰氨基)烟酸 | 60770-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-(乙酰氨基)烟酸
• 英文名称: 4-(acetylamino)nicotinic acid
• 英文别名: 4-acetylamino-nicotinic acid；4-Acetylamino-nicotinsaeure；4-Acetamido-nicotinsaeure；4-Acetamino-nicotinsaeure；4-Acetamidonicotinic acid；4-acetamidopyridine-3-carboxylic acid
• CAS: 60770-86-7
• 化学式: C₈H₈N₂O₃
• 分子量: 180.163
• InChiKey: RXWQRLWVSNNJDZ-UHFFFAOYSA-N

物化性质

• 熔点：
  255 °C
• 沸点：
  465.2±30.0 °C(Predicted)
• 密度：
  1.404±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(乙酰氨基)烟酸 在 硫酸 作用下， 生成 4-氨基烟酸甲酯
  参考文献：
  名称：

  Itai; Ogura, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 292,294

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-4-硝基吡啶-N-氧化物 在 potassium permanganate 、 palladium on activated charcoal 、 溶剂黄146 作用下， 生成 4-(乙酰氨基)烟酸
  参考文献：
  名称：

  Itai; Ogura, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 292,294

  摘要：

  DOI：

文献信息

• Enzymatic Synthesis of Pyridine Nucleotides. Structural Property of Some New NAD-analogs, and Base Conditions Available for the Analog Formation
  作者：Shuichi Tono-oka

  DOI：10.1246/bcsj.55.1531

  日期：1982.5

  prepared by a base-exchange reaction catalyzed by pig-brain NADase. The analogs produced from methyl 4-(methylamino)- and 4-(dimethylamino)nicotinates were proved to be 1,4-dihydropyridine form. On the contrary, the analog obtained from 4-(acetylamino)nicotinamide was shown to be a quaternary pyridinium form. Moreover, an unexpected analog of 1,4-dihydro-4-pyridinone form was given by 4-methoxynicotinamide

  通过猪脑 NADase 催化的碱基交换反应制备了一些新的 β-NAD 类似物。由 4-(甲氨基)-和 4-(二甲氨基)烟酸甲酯产生的类似物被证明是 1,4-二氢吡啶形式。相反，从 4-（乙酰氨基）烟酰胺获得的类似物显示为季吡啶鎓形式。此外，1,4-二氢-4-吡啶酮形式的意外类似物由4-甲氧基烟酰胺给出。已证明对于 NAD 类似物的形成是必不可少的，相关吡啶碱的环氮至少应该在 pH 7 附近没有质子化。有趣的是，发现具有 4-氨基、甲氨基和二甲氨基的烟酸是环氮原子比它们各自的甲酯更碱性。
• The synthesis of pyrido[4,3-d]pyrimidin-4(3H)-ones from 4-amino-nicotinic acid
  作者：A. G. Ismail、D. G. Wibberley

  DOI：10.1039/j39670002613

  日期：——

  Treatment of either a pyrido[4,3-d][1,3]oxazin-4-one or an ethyl 4-amidonicotinate with amines yields a 4-amidonicotinamide which may be cyclised by longer contact with the amine, or by heat, to give a pyrido[4,3-d]-pyrimidin-4(3H)-one. Some typical infrared and nuclear magnetic resonance spectra are discussed.

  用胺处理吡啶并[4,3- d ] [1,3]恶嗪-4-酮或4-ico基烟酸乙酯产生4-ami基烟酰胺，其可通过与胺长时间接触或加热而环化。得到吡啶并[4，3 - d ]-嘧啶-4（3H）-一。讨论了一些典型的红外和核磁共振光谱。
• 4-Aminopyridine derivatives with antiamnesic activity
  作者：A Andreani

  DOI：10.1016/s0223-5234(00)00103-3

  日期：2000.1

  Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.
• 1-AMINOMETHYL- L- PHENYL- CYCLOHEXANE DERIVATIVES AS DDP-IV INHIBITORS
  申请人：Novartis AG

  公开号：EP2124913A1

  公开（公告）日：2009-12-02
• NON-RETINOID ANTAGONISTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE
  申请人：Petrukhin Konstantin

  公开号：US20150126494A1

  公开（公告）日：2015-05-07

  A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a non-retinoid antagonist compound or a pharmaceutically acceptable salt thereof.