2-carbohydroxymethyldithiopyridine-N-oxide | 72632-44-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-carbohydroxymethyldithiopyridine-N-oxide
• 英文别名: 2-[(1-Oxidopyridin-1-ium-2-yl)disulfanyl]acetic acid
• CAS: 72632-44-1
• 化学式: C₇H₇NO₃S₂
• 分子量: 217.269
• InChiKey: QTHYEMVQSJXEME-UHFFFAOYSA-N

物化性质

• 沸点：
  495.2±41.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-巯基吡啶-N-氧化物 在 双氧水 、 溶剂黄146 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 13.0h， 生成 2-carbohydroxymethyldithiopyridine-N-oxide
  参考文献：
  名称：

  Synthesis of disulfides via sulfenylation of alkyl and aryldithiopyridine n-oxides

  摘要：

  Alkyl and aryldithiopyridine N-oxides were prepared by the reaction of 2,2'-dithiopyridine-1,1'-dioxide with various thiols in high yields. Some of the mixed disulfide products could in turn be used to sulfenylate efficiently other thiols. Therefore, practical and efficient synthetic methods for both symmetrical and unsymmetrical disulfides were developed.

  DOI：

  10.1016/s0040-4020(01)86546-7

文献信息

• US4505917A
  申请人：——

  公开号：US4505917A

  公开（公告）日：1985-03-19
• Synthesis of disulfides via sulfenylation of alkyl and aryldithiopyridine n-oxides
  作者：Derek H.R. Barton、Chen Chen、G. Michael Wall

  DOI：10.1016/s0040-4020(01)86546-7

  日期：1991.8

  Alkyl and aryldithiopyridine N-oxides were prepared by the reaction of 2,2'-dithiopyridine-1,1'-dioxide with various thiols in high yields. Some of the mixed disulfide products could in turn be used to sulfenylate efficiently other thiols. Therefore, practical and efficient synthetic methods for both symmetrical and unsymmetrical disulfides were developed.