3,5-dimethyl-1,2,4-trimethoxybenzene | 92421-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,5-dimethyl-1,2,4-trimethoxybenzene
• 英文别名: 1,2,4-Trimethoxy-3,5-dimethylbenzene
• CAS: 92421-42-6
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: RUGCCDOTTHVGBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-dimethyl-1,2,4-trimethoxybenzene 在 氯仿 、 溴 作用下， 生成 1-bromo-2,3,5-trimethoxy-4,6-dimethyl-benzene
  参考文献：
  名称：

  Erdtman; Leon, Anales de la Real Sociedad Espanola de Fisica y Quimica, 1934, vol. 32, p. 614,621

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二甲基-2,5-环己二烯-1,4-二酮 在 三氟化硼乙醚 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 3,5-dimethyl-1,2,4-trimethoxybenzene
  参考文献：
  名称：

  [EN] QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
  [FR] COMPOSÉS DONNEURS D'OXYDE NITRIQUE À BASE DE QUINONE POUR UNE UTILISATION OPHTALMIQUE

  摘要：

  本发明涉及用于治疗和/或预防高血压性青光眼、正常眼压青光眼和眼压增高的新型一氧化氮供体化合物。

  公开号：

  WO2014063923A1

文献信息

• New Drug Delivery System for Crossing the Blood Brain Barrier
  申请人：Lipshutz H. Bruce

  公开号：US20070203080A1

  公开（公告）日：2007-08-30

  New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

  新的泛醌类似物被披露，以及利用这些化合物将药物基团输送到人体的方法。
• [EN] QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS<br/>[FR] COMPOSÉS DONNEURS D'OXYDE NITRIQUE À BASE DE QUINONE
  申请人：NICOX SA

  公开号：WO2013060673A1

  公开（公告）日：2013-05-02

  The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.

  本发明涉及具有喹诚基结构的一氧化氮供体化合物，涉及其制备方法以及它们在治疗病理状况中的应用，其中一氧化氮缺乏在它们的发病机制中起重要作用。
• UBIQUINONE ANALOGS AND METHODS OF USE
  申请人：Lipshutz H. Bruce

  公开号：US20070208086A1

  公开（公告）日：2007-09-06

  New ubiquinone and ubiquinol analogs are disclosed, as well as methods of making and using these compounds.

  本发明揭示了新的泛醌和泛醌醇类似物，以及制备和使用这些化合物的方法。
• Modifier for lithium catalysts
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP0258167A2

  公开（公告）日：1988-03-02

  It has been determined that 1,2,3-trialkoxybenzenes and 1,2,4-trialkoxybenzenes can be utilized in order to increase the vinyl content of polydienes which are prepared utilizing lithium catalyst systems. For instance, it has been determined that 1,2,3-trimethoxybenzene and 1,2,4-trimethoxybenzene are very strong modifiers for utilization in such polymerizations. The utilization of the trialkoxybenzene modifiers of the present invention is highly advantageous because they promote fast polymerization rates and can be used to produce polymers having high vinyl contents.

  已确定 1,2,3-三烷氧基苯和 1,2,4-三烷氧基苯可用于增加利用锂催化剂体系制备的聚二 烯中的乙烯基含量。例如，已确定 1,2,3-三甲氧基苯和 1,2,4-三甲氧基苯是用于此类聚合反应的强改性剂。使用本发明的三烷氧基苯改性剂非常有利，因为它们能促进快速聚合，并可用于生产乙烯基含量高的聚合物。
• Segmented elastomer
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP0438967A1

  公开（公告）日：1991-07-31

  It is important for tire treads to exhibit good wet skid resistance, low rolling resistance, good wear characteristics and good abrasion resistance. This is often accomplished by utilizing a blend of various rubbers in making tire tread compositions. However, some of the desirable characteristics of the individual rubbers in the blend are frequently lost on mixing. The segmented elastomers of this invention offer a unique combination of desirable characteristics for utilization in making tire tread compositions. This invention more specifically discloses a rubber polymer which has an excellent combination of properties for use in making tire treads which is comprised of: (a) a first segment which is comprised of repeat units which are derived from isoprene having a microstructure wherein there are from about 75% to about 98% 1,4-linkages and from about 2% to about 25% 3,4-linkages and wherein the first segment has a number average molecular weight which is within the range of about 25,000 to about 350,000; and (b) a second segment which is comprised of repeat units which are derived from 30 to 95 weight percent 1,3-butadiene and from 5 to 70 weight percent styrene, wherein the sum of (1) the product of 1.7 and the weight percent of styrene in the second segment and (2) the percentage of 1,2-butadiene linkages in the second segment is within the range of about 50% to about 92%, and wherein the second segment has a number average molecular weight which is within the range of about 50,000 to about 350,000.

  轮胎胎面必须具有良好的防滑性、低滚动阻力、良好的磨损特性和耐磨性。这通常是通过在轮胎胎面成分中使用各种橡胶的混合物来实现的。然而，混合橡胶中的单个橡胶的一些理想特性往往会在混合时丧失。本发明的分段弹性体提供了独特的理想特性组合，可用于制造轮胎胎面组合物。本发明更具体地公开了一种橡胶聚合物，它具有用于制造轮胎胎面的优异组合特性，由以下部分组成：(a) 第一段，由异戊二烯衍生的重复单元组成，其微观结构中 1,4-联结占约 75% 至约 98%，3,4-联结占约 2% 至约 25%，第一段的平均分子量在约 25,000 至约 350,000 之间；(b) 第二段由 30%至 95%的 1,3-丁二烯和 5%至 70%的苯乙烯的重复单元组成， 其中(1)1,3-丁二烯的重量百分比与苯乙烯的重量百分比的乘积之和为 1.7 的乘积和第二段中苯乙烯的重量百分比，以及(2) 第二段中 1，2-丁二烯链节的百分比之和在约 50% 至约 92% 的范围内，其中第二段的数均分子量在约 50,000 至约 350,000 的范围内。