Ac-SPYSSDTTPA-NH2

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Ac-SPYSSDTTPA-NH2
• 英文别名: (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-acetamido-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-[[(2S,3R)-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
• 化学式: C₄₅H₆₇N₁₁O₁₉
• 分子量: 1066.09
• InChiKey: DGNCMXARDFPLQN-YQUJPKNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.8
• 重原子数：
  75
• 可旋转键数：
  27
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  475
• 氢给体数：
  16
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  Fmoc-L-丙氨酸 、 Fmoc-L-脯氨酸 、 Fmoc-L-天冬氨酸 beta-叔丁酯 、 乙酸酐 、 Fmoc-O-叔丁基-L-苏氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Ac-SPYSSDTTPA-NH2
  参考文献：
  名称：

  Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES

  摘要：

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00271-7

文献信息

• Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES
  作者：Yasuhiro Nishiyama、Tsutomu Murakami、Suguru Shikama、Keisuke Kurita、Naoki Yamamoto

  DOI：10.1016/s0968-0896(02)00271-7

  日期：2002.12

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.