(3E)-3-hexenoic hydroxamic acid | 114142-24-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3E)-3-hexenoic hydroxamic acid
• 英文别名: (E)-N-hydroxyhex-3-enamide
• CAS: 114142-24-4
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: CHOFZIYCTUITDS-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3E)-3-hexenoic hydroxamic acid 在 水 、 溴 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 0.08h， 生成 Carbonic acid benzyl ester (S)-2-((R)-1-bromo-propyl)-4-oxo-azetidin-1-yl ester
  参考文献：
  名称：

  γ-substituent effects on the oxidative cyclization of o-acyl β,γ-unsaturated hydroxamates

  摘要：

  DOI：

  10.1016/s0040-4039(01)91346-2
• 作为产物：
  描述：

  反式-3-己烯酸 生成 (3E)-3-hexenoic hydroxamic acid
  参考文献：
  名称：

  γ-substituent effects on the oxidative cyclization of o-acyl β,γ-unsaturated hydroxamates

  摘要：

  DOI：

  10.1016/s0040-4039(01)91346-2

文献信息

• N-hydroxy γ-lactams or cyclic N-hydroxy imidates from the organoselenium-induced cyclization of β,γ-unsaturated hydroxamic acids
  作者：Marcello Tiecco、Lorenzo Testaferri、Marco Tingoli、Francesca Marini

  DOI：10.1039/c39940000221

  日期：——

  The organoselenium-induced ring-closure reactions of γ-substituted β, γ-unsaturated hydroxamic acids afforded cyclic phenylseleno N-hydroxy imidates or phenylseleno N-hydroxy γ-lactams as the kinetically or thermodynamically controlled products, respectively.

  有机硒诱导的γ-取代的β、γ-不饱和异羟肟酸的闭环反应分别提供环状苯基硒基N-羟基亚氨酸盐或苯基硒基N-羟基γ-内酰胺作为动力学或热力学控制的产物。
• A sulfur-containing diselenide as an efficient chiral reagent in asymmetric selenocyclization reactions
  作者：Marcello Tiecco、Lorenzo Testaferri、Francesca Marini、Silvia Sternativo、Luana Bagnoli、Claudio Santi、Andrea Temperini

  DOI：10.1016/s0957-4166(01)00248-8

  日期：2001.6

  Treatment of the di-2-[(IS)-1-(methylthio)ethyl]phenyl diselenide with bromine and silver triflate afforded the corresponding selenyl triflate which was used in situ as a strongly electrophilic selenium reagent to effect the asymmetric synthesis of oxygen- or nitrogen-containing heterocycles. Cyclic ethers, lactones, lactams or N-protected pyrrolidines have been prepared in good yield with complete regioselectivity and high diastereoselectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Tiecco Marcelo, Testaferri Lorenzo, Tingoli Marco, Marini Francesca, J. Chem. Soc. Chem. Commun, (1994) N 2, S 221-222
  作者：Tiecco Marcelo, Testaferri Lorenzo, Tingoli Marco, Marini Francesca

  DOI：——

  日期：——
• RAJENDRA, G.;MILLER, MARVIN J., TETRAHEDRON LETT., 28,(1987) N 50, 6257-6260
  作者：RAJENDRA, G.、MILLER, MARVIN J.

  DOI：——

  日期：——
• γ-substituent effects on the oxidative cyclization of o-acyl β,γ-unsaturated hydroxamates
  作者：G. Rajendra、Marvin J. Miller

  DOI：10.1016/s0040-4039(01)91346-2

  日期：1987.1