N-甲基-1-苯氧基丙烷-2-胺 | 66022-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: N-甲基-1-苯氧基丙烷-2-胺
• 英文名称: methyl-(β-phenoxy-isopropyl)-amine
• 英文别名: N-methyl-1-phenoxypropan-2-amine
• CAS: 66022-28-4
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: FDJQVAJHMSBHDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基-1-苯氧基丙烷-2-胺 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 3-Oxobutanoic acid 2-ethyl ester
  参考文献：
  名称：

  New 1,4-dihydropyridine derivatives combining calcium antagonism and .alpha.-adrenolytic properties

  摘要：

  A series of twelve 1,4-dihydropyridine derivatives incorporating an alpha-adrenergic moiety in one of the ester chains was synthesized. The compounds were evaluated for their calcium antagonist activities by the inhibition of [3H]nitrendipine binding and, in vitro, on pig coronary artery. Their alpha 1- and alpha 2-adrenolytic effects were assessed from their inhibition of [3H]prazosin and [3H]yohimbine binding and, in vitro, on rat aorta and guinea pig vas deferens. Compounds 6 and 9-11 displayed strong calcium antagonist activities, identical with that of nicardipine. The moderate alpha-adrenolytic properties observed were attributed to the presence of alpha-adrenergic moieties. The four chiral derivatives 6a (R,R), 6b (S,S), 6c (S,R), and 6d (R,S) with an N-methyl-N-(benzodioxanylmethyl)amino group on the ester chain were prepared and tested as done previously. Some structure-activity relationships are discussed.

  DOI：

  10.1021/jm00126a042
• 作为产物：
  描述：

  苯氧基丙酮 、 甲胺 在 镍 氢气 作用下， 以 乙醇 为溶剂， 25.0 ℃ 、3.43 MPa 条件下， 生成 N-甲基-1-苯氧基丙烷-2-胺
  参考文献：
  名称：

  BE626725

  摘要：

  公开号：

文献信息

• Polonovski et al., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1951, vol. 233, p. 1120
  作者：Polonovski et al.

  DOI：——

  日期：——
• BE626725
  申请人：——

  公开号：——

  公开（公告）日：——
• MARCINIAK, GILBERT;DELGADO, ANTONIO;LECLERC, GERARD;VELLY, JEANNE;DECKER,+, J. MED. CHEM., 32,(1989) N, C. 1402-1407
  作者：MARCINIAK, GILBERT、DELGADO, ANTONIO、LECLERC, GERARD、VELLY, JEANNE、DECKER,+

  DOI：——

  日期：——
• Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof
  申请人：Eickmeier Christian

  公开号：US20090325940A1

  公开（公告）日：2009-12-31

  The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R 1 to R 15 , A, B, L, i as well as X 1 -X 4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
• US4097528A
  申请人：——

  公开号：US4097528A

  公开（公告）日：1978-06-27