(S)-2-{2-[3-(3H-Imidazol-4-ylmethyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid | 345312-06-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-{2-[3-(3H-Imidazol-4-ylmethyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid
• 英文别名: (2S)-2-(2-(3-((1H-imidazol-5-yl)methyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid；(2S)-2-[[2-[3-(1H-imidazol-5-ylmethyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl]acetyl]amino]-4-methylsulfanylbutanoic acid
• CAS: 345312-06-3
• 化学式: C₂₅H₂₇N₅O₅S
• 分子量: 509.586
• InChiKey: IJXSXCBEAJLFHS-JINQPTGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-methyl-5-(1-naphthyl)-2,4-imidazolidinedione 在 sodium hydride 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 生成 (S)-2-{2-[3-(3H-Imidazol-4-ylmethyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid
  参考文献：
  名称：

  Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase

  摘要：

  1, 3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.074

文献信息

• Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase
  作者：Jinho Lee、Jonghyun Kim、Jong Sung Koh、Hyun-Ho Chung、Kyoung-Hee Kim

  DOI：10.1016/j.bmcl.2005.12.074

  日期：2006.4

  1, 3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. (C) 2006 Elsevier Ltd. All rights reserved.